DegronMD - P14621(ACYP2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R32T	TCGA-38-4626	LUAD	TCGA	FRMYTE	LIG_APCC_ABBA_1	23:28	Mutation rewiring degron network	0.2222
p.E13Q	TCGA-63-A5MV	LUSC	TCGA	FRMYTE	LIG_APCC_ABBA_1	23:28	Mutation rewiring degron network	0.0556
p.D29Y	TCGA-86-7701	LUAD	TCGA	FRMYTE	LIG_APCC_ABBA_1	23:28	Mutation rewiring degron network	0.3056
p.R24G	TCGA-BR-4361	STAD	TCGA	FRMYTE	LIG_APCC_ABBA_1	23:28	Mutation altering degron motif	0.6457
p.L35F	DO50091	COAD	ICGC	FRMYTE	LIG_APCC_ABBA_1	23:28	Mutation rewiring degron network	0.1389
p.R33G	DO234206	ESAD	ICGC	FRMYTE	LIG_APCC_ABBA_1	23:28	Mutation substituting flanking lysine	0.3056
p.R33G	ACH-000853	Lung Cancer	CCLE	FRMYTE	LIG_APCC_ABBA_1	23:28	Mutation substituting flanking lysine	0.3056
p.R32K	DO11854	GBM	ICGC	FRMYTE	LIG_APCC_ABBA_1	23:28	Mutation rewiring degron network	0.2222
p.Y22C	DO22293	LGG	ICGC	FRMYTE	LIG_APCC_ABBA_1	23:28	Mutation rewiring degron network	0.3056
p.V38L	DO228974	LICA	ICGC	FRMYTE	LIG_APCC_ABBA_1	23:28	Mutation rewiring degron network	0.0556
p.A32S	DO229019	LICA	ICGC	FRMYTE	LIG_APCC_ABBA_1	23:28	Mutation rewiring degron network	0.2222
p.N22Y	DO231049	LUSC	ICGC	FRMYTE	LIG_APCC_ABBA_1	23:28	Mutation rewiring degron network	0.3056
p.L20P	DO26614	LUSC	ICGC	FRMYTE	LIG_APCC_ABBA_1	23:28	Mutation rewiring degron network	0.25
p.P25S	DO222632	MELA	ICGC	FRMYTE	LIG_APCC_ABBA_1	23:28	Mutation altering degron motif	0.6752
p.N36H	SIDM00358	Gastric Carcinoma	GDSC	FRMYTE	LIG_APCC_ABBA_1	23:28	Mutation rewiring degron network	0.1111
p.N36H	ACH-000144	Gastric Cancer	CCLE	FRMYTE	LIG_APCC_ABBA_1	23:28	Mutation rewiring degron network	0.1111
p.N33K	ACH-000888	Lung Cancer	CCLE	FRMYTE	LIG_APCC_ABBA_1	23:28	Mutation substituting flanking lysine	0.3056
p.T27S	ACH-002027	Endometrial/Uterine Cancer	CCLE	FRMYTE	LIG_APCC_ABBA_1	23:28	Mutation altering degron motif	0.7116

Kaplan plot for ACYP2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ACYP2

UniProt ID: P14621

Entrez ID: 98

Protein name: Acylphosphatase-2 (EC 3.6.1.7) (Acylphosphatase, muscle type isozyme) (Acylphosphate phosphohydrolase 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ACYP2 in