DegronMD

Uniprot ID: P14621

Source protein: Acylphosphatase-2

Source gene: ACYP2

Class: LIG_APCC_ABBA_1

Location: 23:28

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5206

ASA_SCORE: 49.75

COIL: 0.1217

CONS_SCORE: 0.6159

DSS_SCORE: 0.1263

HELIX: 0.741

FCONS_SCORE: 0.9278

RIG_SCORE: 0.9304

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R32T	TCGA-38-4626	LUAD	TCGA	FRMYTE	LIG_APCC_ABBA_1	0.2222
p.E13Q	TCGA-63-A5MV	LUSC	TCGA	FRMYTE	LIG_APCC_ABBA_1	0.0556
p.D29Y	TCGA-86-7701	LUAD	TCGA	FRMYTE	LIG_APCC_ABBA_1	0.3056
p.R24G	TCGA-BR-4361	STAD	TCGA	FRMYTE	LIG_APCC_ABBA_1	0.6457
p.L35F	DO50091	COAD	ICGC	FRMYTE	LIG_APCC_ABBA_1	0.1389
p.R33G	DO234206	ESAD	ICGC	FRMYTE	LIG_APCC_ABBA_1	0.3056
p.R33G	ACH-000853	Lung Cancer	CCLE	FRMYTE	LIG_APCC_ABBA_1	0.3056
p.R32K	DO11854	GBM	ICGC	FRMYTE	LIG_APCC_ABBA_1	0.2222
p.Y22C	DO22293	LGG	ICGC	FRMYTE	LIG_APCC_ABBA_1	0.3056
p.V38L	DO228974	LICA	ICGC	FRMYTE	LIG_APCC_ABBA_1	0.0556
p.A32S	DO229019	LICA	ICGC	FRMYTE	LIG_APCC_ABBA_1	0.2222
p.N22Y	DO231049	LUSC	ICGC	FRMYTE	LIG_APCC_ABBA_1	0.3056
p.L20P	DO26614	LUSC	ICGC	FRMYTE	LIG_APCC_ABBA_1	0.25
p.P25S	DO222632	MELA	ICGC	FRMYTE	LIG_APCC_ABBA_1	0.6752
p.N36H	SIDM00358	Gastric Carcinoma	GDSC	FRMYTE	LIG_APCC_ABBA_1	0.1111
p.N36H	ACH-000144	Gastric Cancer	CCLE	FRMYTE	LIG_APCC_ABBA_1	0.1111
p.N33K	ACH-000888	Lung Cancer	CCLE	FRMYTE	LIG_APCC_ABBA_1	0.3056
p.T27S	ACH-002027	Endometrial/Uterine Cancer	CCLE	FRMYTE	LIG_APCC_ABBA_1	0.7116

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P14621	Acylphosphatase-2	LIG_APCC_ABBA_1	23:28	FRMYTE	APC,CDC20,FZR1	0.5206	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons