DegronMD - P14921(ETS1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q293H	TCGA-66-2773	LUSC	TCGA	SSFNSLQRVPSY	DEG_COP1_1	272:283	Mutation rewiring degron network	0.0556
p.Q293H	DO26536	LUSC	ICGC	SSFNSLQRVPSY	DEG_COP1_1	272:283	Mutation rewiring degron network	0.0556
p.S286G	TCGA-A5-A1OF	UCEC	TCGA	SSFNSLQRVPSY	DEG_COP1_1	272:283	Mutation rewiring degron network	0.25
p.S286G	DO42568	UCEC	ICGC	SSFNSLQRVPSY	DEG_COP1_1	272:283	Mutation rewiring degron network	0.25
p.V275I	TCGA-AP-A051	UCEC	TCGA	SSFNSLQRVPSY	DEG_COP1_1	272:283	Mutation altering degron motif	0.7076
p.V275I	DO42673	UCEC	ICGC	SSFNSLQRVPSY	DEG_COP1_1	272:283	Mutation altering degron motif	0.7076
p.Q264H	TCGA-B5-A11E	UCEC	TCGA	SSFNSLQRVPSY	DEG_COP1_1	272:283	Mutation rewiring degron network	0.1111
p.Q264H	DO41644	UCEC	ICGC	SSFNSLQRVPSY	DEG_COP1_1	272:283	Mutation rewiring degron network	0.1111
p.R287H	TCGA-D1-A103	UCEC	TCGA	SSFNSLQRVPSY	DEG_COP1_1	272:283	Mutation rewiring degron network	0.2222
p.R287H	DO42312	UCEC	ICGC	SSFNSLQRVPSY	DEG_COP1_1	272:283	Mutation rewiring degron network	0.2222
p.R287H	SIDM01617	Endometrial Carcinoma	GDSC	SSFNSLQRVPSY	DEG_COP1_1	272:283	Mutation rewiring degron network	0.2222
p.D278Y	TCGA-F5-6814	READ	TCGA	SSFNSLQRVPSY	DEG_COP1_1	272:283	Mutation altering degron motif	0.7325
p.D278Y	DO36556	READ	ICGC	SSFNSLQRVPSY	DEG_COP1_1	272:283	Mutation altering degron motif	0.7325
p.T285I	TCGA-GC-A3YS	BLCA	TCGA	SSFNSLQRVPSY	DEG_COP1_1	272:283	Mutation blocking phosphorylation signal	0.7222
p.T285I	DO850	BLCA	ICGC	SSFNSLQRVPSY	DEG_COP1_1	272:283	Mutation blocking phosphorylation signal	0.7222
p.P277T	DO224732	BRCA	ICGC	SSFNSLQRVPSY	DEG_COP1_1	272:283	Mutation altering degron motif	0.7031
p.V275A	DO233245	GACA	ICGC	SSFNSLQRVPSY	DEG_COP1_1	272:283	Mutation altering degron motif	0.6936
p.Q264K	DO228971	LICA	ICGC	SSFNSLQRVPSY	DEG_COP1_1	272:283	Mutation rewiring degron network	0.1111
p.P281Q	DO229018	LICA	ICGC	SSFNSLQRVPSY	DEG_COP1_1	272:283	Mutation altering degron motif	0.7035
p.A285D	DO229018	LICA	ICGC	SSFNSLQRVPSY	DEG_COP1_1	272:283	Mutation blocking phosphorylation signal	0.7222
p.T270K	DO229015	LICA	ICGC	SSFNSLQRVPSY	DEG_COP1_1	272:283	Mutation blocking phosphorylation signal	0.7222
p.A269T	DO50970	LICA	ICGC	SSFNSLQRVPSY	DEG_COP1_1	272:283	Mutation blocking phosphorylation signal	0.6944
p.K289T	DO232224	PBCA	ICGC	SSFNSLQRVPSY	DEG_COP1_1	272:283	Mutation rewiring degron network	0.1667
p.F276L	DO218894	SKCA	ICGC	SSFNSLQRVPSY	DEG_COP1_1	272:283	Mutation altering degron motif	0.6981
p.W269G	DO37563	SKCM	ICGC	SSFNSLQRVPSY	DEG_COP1_1	272:283	Mutation blocking phosphorylation signal	0.6944
p.R286G	DO43090	UCEC	ICGC	SSFNSLQRVPSY	DEG_COP1_1	272:283	Mutation rewiring degron network	0.25
p.L290F	SIDM00387	Neuroblastoma	GDSC	SSFNSLQRVPSY	DEG_COP1_1	272:283	Mutation rewiring degron network	0.1389
p.L290F	MHH-NB-11	autonomic ganglia	COSMIC	SSFNSLQRVPSY	DEG_COP1_1	272:283	Mutation rewiring degron network	0.1389
p.S285R	ACH-000728	Leukemia	CCLE	SSFNSLQRVPSY	DEG_COP1_1	272:283	Mutation blocking phosphorylation signal	0.7222
p.S273Y	ACH-000784	Esophageal Cancer	CCLE	SSFNSLQRVPSY	DEG_COP1_1	272:283	Mutation altering degron motif	0.8231
p.S273Y	KYSE-70	oesophagus	COSMIC	SSFNSLQRVPSY	DEG_COP1_1	272:283	Mutation altering degron motif	0.8231
p.S267P	ACH-000959	Colon/Colorectal Cancer	CCLE	SSFNSLQRVPSY	DEG_COP1_1	272:283	Mutation blocking phosphorylation signal	0.6389
p.R279H	ACH-000989	Colon/Colorectal Cancer	CCLE	SSFNSLQRVPSY	DEG_COP1_1	272:283	Mutation altering degron motif	0.7133
p.R279H	SNU-175	large intestine	COSMIC	SSFNSLQRVPSY	DEG_COP1_1	272:283	Mutation altering degron motif	0.7133
p.R263H	GR-ST	haematopoietic and lymphoid tissue	COSMIC	SSFNSLQRVPSY	DEG_COP1_1	272:283	Mutation rewiring degron network	0.0833

Kaplan plot for ETS1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ETS1

UniProt ID: P14921

Entrez ID: 2113

Protein name: Protein C-ets-1 (p54)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ETS1 in