DegronMD

Uniprot ID: P14921

Source protein: Protein C-ets-1

Source gene: ETS1

Class: DEG_COP1_1

Location: 272:283

E3 ligase: COP1

DEGRON score: 0.9984

ASA_SCORE: 65.0667

COIL: 0.847

CONS_SCORE: 0.4061

DSS_SCORE: 0.4071

HELIX: 0.0851

FCONS_SCORE: 1.0302

RIG_SCORE: 0.6824

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q293H	TCGA-66-2773	LUSC	TCGA	SSFNSLQRVPSY	DEG_COP1_1	0.0556
p.Q293H	DO26536	LUSC	ICGC	SSFNSLQRVPSY	DEG_COP1_1	0.0556
p.S286G	TCGA-A5-A1OF	UCEC	TCGA	SSFNSLQRVPSY	DEG_COP1_1	0.25
p.S286G	DO42568	UCEC	ICGC	SSFNSLQRVPSY	DEG_COP1_1	0.25
p.V275I	TCGA-AP-A051	UCEC	TCGA	SSFNSLQRVPSY	DEG_COP1_1	0.7076
p.V275I	DO42673	UCEC	ICGC	SSFNSLQRVPSY	DEG_COP1_1	0.7076
p.Q264H	TCGA-B5-A11E	UCEC	TCGA	SSFNSLQRVPSY	DEG_COP1_1	0.1111
p.Q264H	DO41644	UCEC	ICGC	SSFNSLQRVPSY	DEG_COP1_1	0.1111
p.R287H	TCGA-D1-A103	UCEC	TCGA	SSFNSLQRVPSY	DEG_COP1_1	0.2222
p.R287H	DO42312	UCEC	ICGC	SSFNSLQRVPSY	DEG_COP1_1	0.2222
p.R287H	SIDM01617	Endometrial Carcinoma	GDSC	SSFNSLQRVPSY	DEG_COP1_1	0.2222
p.D278Y	TCGA-F5-6814	READ	TCGA	SSFNSLQRVPSY	DEG_COP1_1	0.7325
p.D278Y	DO36556	READ	ICGC	SSFNSLQRVPSY	DEG_COP1_1	0.7325
p.T285I	TCGA-GC-A3YS	BLCA	TCGA	SSFNSLQRVPSY	DEG_COP1_1	0.7222
p.T285I	DO850	BLCA	ICGC	SSFNSLQRVPSY	DEG_COP1_1	0.7222
p.P277T	DO224732	BRCA	ICGC	SSFNSLQRVPSY	DEG_COP1_1	0.7031
p.V275A	DO233245	GACA	ICGC	SSFNSLQRVPSY	DEG_COP1_1	0.6936
p.Q264K	DO228971	LICA	ICGC	SSFNSLQRVPSY	DEG_COP1_1	0.1111
p.P281Q	DO229018	LICA	ICGC	SSFNSLQRVPSY	DEG_COP1_1	0.7035
p.A285D	DO229018	LICA	ICGC	SSFNSLQRVPSY	DEG_COP1_1	0.7222
p.T270K	DO229015	LICA	ICGC	SSFNSLQRVPSY	DEG_COP1_1	0.7222
p.A269T	DO50970	LICA	ICGC	SSFNSLQRVPSY	DEG_COP1_1	0.6944
p.K289T	DO232224	PBCA	ICGC	SSFNSLQRVPSY	DEG_COP1_1	0.1667
p.F276L	DO218894	SKCA	ICGC	SSFNSLQRVPSY	DEG_COP1_1	0.6981
p.W269G	DO37563	SKCM	ICGC	SSFNSLQRVPSY	DEG_COP1_1	0.6944
p.R286G	DO43090	UCEC	ICGC	SSFNSLQRVPSY	DEG_COP1_1	0.25
p.L290F	SIDM00387	Neuroblastoma	GDSC	SSFNSLQRVPSY	DEG_COP1_1	0.1389
p.L290F	MHH-NB-11	autonomic_ganglia	COSMIC	SSFNSLQRVPSY	DEG_COP1_1	0.1389
p.S285R	ACH-000728	Leukemia	CCLE	SSFNSLQRVPSY	DEG_COP1_1	0.7222
p.S273Y	ACH-000784	Esophageal Cancer	CCLE	SSFNSLQRVPSY	DEG_COP1_1	0.8231
p.S273Y	KYSE-70	oesophagus	COSMIC	SSFNSLQRVPSY	DEG_COP1_1	0.8231
p.S267P	ACH-000959	Colon/Colorectal Cancer	CCLE	SSFNSLQRVPSY	DEG_COP1_1	0.6389
p.R279H	ACH-000989	Colon/Colorectal Cancer	CCLE	SSFNSLQRVPSY	DEG_COP1_1	0.7133
p.R279H	SNU-175	large_intestine	COSMIC	SSFNSLQRVPSY	DEG_COP1_1	0.7133
p.R263H	GR-ST	haematopoietic_and_lymphoid_tissue	COSMIC	SSFNSLQRVPSY	DEG_COP1_1	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SSFNSLQRVPSY

Degron related mutations and impact score

Drug responses associated with ETS1 mutations

All proteins holding degron of SSFNSLQRVPSY

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P14921	Protein C-ets-1	DEG_COP1_1	272:283	SSFNSLQRVPSY	COP1	0.9984	More...