DegronMD - P15088(CPA3)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S260C	TCGA-49-AARO	LUAD	TCGA	FNASWNSI	DEG_MDM2_SWIB_1	254:261	Mutation altering degron motif	0.7541
p.S260C	DO218924	LUAD	ICGC	FNASWNSI	DEG_MDM2_SWIB_1	254:261	Mutation altering degron motif	0.7541
p.F254C	TCGA-B5-A0JY	UCEC	TCGA	FNASWNSI	DEG_MDM2_SWIB_1	254:261	Mutation altering degron motif	0.7108
p.F254C	DO43041	UCEC	ICGC	FNASWNSI	DEG_MDM2_SWIB_1	254:261	Mutation altering degron motif	0.7108
p.F254V	TCGA-BS-A0UF	UCEC	TCGA	FNASWNSI	DEG_MDM2_SWIB_1	254:261	Mutation altering degron motif	0.7068
p.F254V	DO41488	UCEC	ICGC	FNASWNSI	DEG_MDM2_SWIB_1	254:261	Mutation altering degron motif	0.7068
p.P262S	TCGA-D3-A8GI	SKCM	TCGA	FNASWNSI	DEG_MDM2_SWIB_1	254:261	Mutation rewiring degron network	0.3056
p.P262S	DO50284	SKCM	ICGC	FNASWNSI	DEG_MDM2_SWIB_1	254:261	Mutation rewiring degron network	0.3056
p.D266N	TCGA-FD-A3B5	BLCA	TCGA	FNASWNSI	DEG_MDM2_SWIB_1	254:261	Mutation rewiring degron network	0.1944
p.D266N	DO714	BLCA	ICGC	FNASWNSI	DEG_MDM2_SWIB_1	254:261	Mutation rewiring degron network	0.1944
p.G247R	TCGA-NJ-A4YQ	LUAD	TCGA	FNASWNSI	DEG_MDM2_SWIB_1	254:261	Mutation rewiring degron network	0.1389
p.G247R	DO218944	LUAD	ICGC	FNASWNSI	DEG_MDM2_SWIB_1	254:261	Mutation rewiring degron network	0.1389
p.N271K	DO222762	COCA	ICGC	FNASWNSI	DEG_MDM2_SWIB_1	254:261	Mutation rewiring degron network	0.0556
p.D270N	DO222677	ESCA	ICGC	FNASWNSI	DEG_MDM2_SWIB_1	254:261	Mutation rewiring degron network	0.0833
p.I246V	DO50804	LIRI	ICGC	FNASWNSI	DEG_MDM2_SWIB_1	254:261	Mutation rewiring degron network	0.1111
p.D270G	SIDM00193	Colorectal Carcinoma	GDSC	FNASWNSI	DEG_MDM2_SWIB_1	254:261	Mutation rewiring degron network	0.0833
p.D270G	ACH-000991	Colon/Colorectal Cancer	CCLE	FNASWNSI	DEG_MDM2_SWIB_1	254:261	Mutation rewiring degron network	0.0833
p.D270G	SNU-81	large intestine	COSMIC	FNASWNSI	DEG_MDM2_SWIB_1	254:261	Mutation rewiring degron network	0.0833
p.P267A	SIDM00417	Plasma Cell Myeloma	GDSC	FNASWNSI	DEG_MDM2_SWIB_1	254:261	Mutation rewiring degron network	0.1667
p.P267A	SIDM00526	Chronic Myelogenous Leukemia	GDSC	FNASWNSI	DEG_MDM2_SWIB_1	254:261	Mutation rewiring degron network	0.1667
p.P267A	U-266	haematopoietic and lymphoid tissue	COSMIC	FNASWNSI	DEG_MDM2_SWIB_1	254:261	Mutation rewiring degron network	0.1667

Kaplan plot for CPA3 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CPA3

UniProt ID: P15088

Entrez ID: 1359

Protein name: Mast cell carboxypeptidase A (MC-CPA) (EC 3.4.17.1) (Carboxypeptidase A3)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for CPA3 in