DegronMD

Uniprot ID: P15088

Source protein: Mast cell carboxypeptidase A

Source gene: CPA3

Class: DEG_MDM2_SWIB_1

Location: 254:261

E3 ligase: MDM2

DEGRON score: 0.9973

ASA_SCORE: 47.8625

COIL: 0.8675

CONS_SCORE: 0.5231

DSS_SCORE: 0.4383

HELIX: 0.0424

FCONS_SCORE: 0.8732

RIG_SCORE: 0.7134

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S260C	TCGA-49-AARO	LUAD	TCGA	FNASWNSI	DEG_MDM2_SWIB_1	0.7541
p.S260C	DO218924	LUAD	ICGC	FNASWNSI	DEG_MDM2_SWIB_1	0.7541
p.F254C	TCGA-B5-A0JY	UCEC	TCGA	FNASWNSI	DEG_MDM2_SWIB_1	0.7108
p.F254C	DO43041	UCEC	ICGC	FNASWNSI	DEG_MDM2_SWIB_1	0.7108
p.F254V	TCGA-BS-A0UF	UCEC	TCGA	FNASWNSI	DEG_MDM2_SWIB_1	0.7068
p.F254V	DO41488	UCEC	ICGC	FNASWNSI	DEG_MDM2_SWIB_1	0.7068
p.P262S	TCGA-D3-A8GI	SKCM	TCGA	FNASWNSI	DEG_MDM2_SWIB_1	0.3056
p.P262S	DO50284	SKCM	ICGC	FNASWNSI	DEG_MDM2_SWIB_1	0.3056
p.D266N	TCGA-FD-A3B5	BLCA	TCGA	FNASWNSI	DEG_MDM2_SWIB_1	0.1944
p.D266N	DO714	BLCA	ICGC	FNASWNSI	DEG_MDM2_SWIB_1	0.1944
p.G247R	TCGA-NJ-A4YQ	LUAD	TCGA	FNASWNSI	DEG_MDM2_SWIB_1	0.1389
p.G247R	DO218944	LUAD	ICGC	FNASWNSI	DEG_MDM2_SWIB_1	0.1389
p.N271K	DO222762	COCA	ICGC	FNASWNSI	DEG_MDM2_SWIB_1	0.0556
p.D270N	DO222677	ESCA	ICGC	FNASWNSI	DEG_MDM2_SWIB_1	0.0833
p.I246V	DO50804	LIRI	ICGC	FNASWNSI	DEG_MDM2_SWIB_1	0.1111
p.D270G	SIDM00193	Colorectal Carcinoma	GDSC	FNASWNSI	DEG_MDM2_SWIB_1	0.0833
p.D270G	ACH-000991	Colon/Colorectal Cancer	CCLE	FNASWNSI	DEG_MDM2_SWIB_1	0.0833
p.D270G	SNU-81	large_intestine	COSMIC	FNASWNSI	DEG_MDM2_SWIB_1	0.0833
p.P267A	SIDM00417	Plasma Cell Myeloma	GDSC	FNASWNSI	DEG_MDM2_SWIB_1	0.1667
p.P267A	SIDM00526	Chronic Myelogenous Leukemia	GDSC	FNASWNSI	DEG_MDM2_SWIB_1	0.1667
p.P267A	U-266	haematopoietic_and_lymphoid_tissue	COSMIC	FNASWNSI	DEG_MDM2_SWIB_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P15088	Mast cell carboxypeptidase A	DEG_MDM2_SWIB_1	254:261	FNASWNSI	MDM2	0.9973	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons