DegronMD - P15172(MYOD1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P202Q	TCGA-55-6981	LUAD	TCGA	DGMMDYSGPP	CBL_PTK	208:217	Mutation rewiring degron network	0.1667
p.P202Q	DO24265	LUAD	ICGC	DGMMDYSGPP	CBL_PTK	208:217	Mutation rewiring degron network	0.1667
p.P216T	TCGA-94-8035	LUSC	TCGA	DGMMDYSGPP	CBL_PTK	208:217	Mutation altering degron motif	0.5919
p.P216T	DO219173	LUSC	ICGC	DGMMDYSGPP	CBL_PTK	208:217	Mutation altering degron motif	0.5919
p.A220T	TCGA-AU-6004	COAD	TCGA	DGMMDYSGPP	CBL_PTK	208:217	Mutation rewiring degron network	0.25
p.A220T	DO7780	COAD	ICGC	DGMMDYSGPP	CBL_PTK	208:217	Mutation rewiring degron network	0.25
p.S218R	TCGA-DD-A3A7	LIHC	TCGA	DGMMDYSGPP	CBL_PTK	208:217	Mutation rewiring degron network	0.3056
p.S218R	DO44982	LIHC	ICGC	DGMMDYSGPP	CBL_PTK	208:217	Mutation rewiring degron network	0.3056
p.S218R	ACH-002287	Colon/Colorectal Cancer	CCLE	DGMMDYSGPP	CBL_PTK	208:217	Mutation rewiring degron network	0.3056
p.S218R	NCI-H630	large intestine	COSMIC	DGMMDYSGPP	CBL_PTK	208:217	Mutation rewiring degron network	0.3056
p.R221W	TCGA-FI-A2D5	UCEC	TCGA	DGMMDYSGPP	CBL_PTK	208:217	Mutation rewiring degron network	0.2222
p.R221W	DO234462	ESAD	ICGC	DGMMDYSGPP	CBL_PTK	208:217	Mutation rewiring degron network	0.2222
p.R221W	DO41331	UCEC	ICGC	DGMMDYSGPP	CBL_PTK	208:217	Mutation rewiring degron network	0.2222
p.R223W	TCGA-SL-A6JA	UCEC	TCGA	DGMMDYSGPP	CBL_PTK	208:217	Mutation rewiring degron network	0.1667
p.R223W	DO219787	UCEC	ICGC	DGMMDYSGPP	CBL_PTK	208:217	Mutation rewiring degron network	0.1667
p.R203L	DO233641	GACA	ICGC	DGMMDYSGPP	CBL_PTK	208:217	Mutation rewiring degron network	0.1944
p.N224D	DO233935	GACA	ICGC	DGMMDYSGPP	CBL_PTK	208:217	Mutation rewiring degron network	0.1389
p.C206R	DO228338	MALY	ICGC	DGMMDYSGPP	CBL_PTK	208:217	Mutation rewiring degron network	0.2778
p.C206R	SIDM00948	Burkitt's Lymphoma	GDSC	DGMMDYSGPP	CBL_PTK	208:217	Mutation rewiring degron network	0.2778
p.C206R	ACH-002232	Lymphoma	CCLE	DGMMDYSGPP	CBL_PTK	208:217	Mutation rewiring degron network	0.2778
p.C206R	DG-75	haematopoietic and lymphoid tissue	COSMIC	DGMMDYSGPP	CBL_PTK	208:217	Mutation rewiring degron network	0.2778
p.M211I	SIDM01274	Esophageal Carcinoma	GDSC	DGMMDYSGPP	CBL_PTK	208:217	Mutation altering degron motif	0.6507
p.G219S	SIDM00449	B-Lymphoblastic Leukemia	GDSC	DGMMDYSGPP	CBL_PTK	208:217	Mutation rewiring degron network	0.2778
p.G219S	ACH-000922	Leukemia	CCLE	DGMMDYSGPP	CBL_PTK	208:217	Mutation rewiring degron network	0.2778
p.G219S	RCH-ACV	haematopoietic and lymphoid tissue	COSMIC	DGMMDYSGPP	CBL_PTK	208:217	Mutation rewiring degron network	0.2778
p.A199V	SIDM00444	Esophageal Carcinoma	GDSC	DGMMDYSGPP	CBL_PTK	208:217	Mutation rewiring degron network	0.0833
p.A199V	ACH-001368	Esophageal Cancer	CCLE	DGMMDYSGPP	CBL_PTK	208:217	Mutation rewiring degron network	0.0833
p.A199V	OACM5-1	oesophagus	COSMIC	DGMMDYSGPP	CBL_PTK	208:217	Mutation rewiring degron network	0.0833
p.P202L	SIDM00498	Colorectal Carcinoma	GDSC	DGMMDYSGPP	CBL_PTK	208:217	Mutation rewiring degron network	0.1667
p.P202L	ACH-000970	Colon/Colorectal Cancer	CCLE	DGMMDYSGPP	CBL_PTK	208:217	Mutation rewiring degron network	0.1667
p.P202L	SNU-C5	large intestine	COSMIC	DGMMDYSGPP	CBL_PTK	208:217	Mutation rewiring degron network	0.1667
p.R223Q	SIDM00951	T-Lymphoblastic Leukemia	GDSC	DGMMDYSGPP	CBL_PTK	208:217	Mutation rewiring degron network	0.1667
p.R223Q	ACH-002222	Leukemia	CCLE	DGMMDYSGPP	CBL_PTK	208:217	Mutation rewiring degron network	0.1667
p.R223Q	CTV-1	haematopoietic and lymphoid tissue	COSMIC	DGMMDYSGPP	CBL_PTK	208:217	Mutation rewiring degron network	0.1667

Kaplan plot for MYOD1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MYOD1

UniProt ID: P15172

Entrez ID: 4654

Protein name: Myoblast determination protein 1 (Class C basic helix-loop-helix protein 1) (bHLHc1) (Myogenic factor 3) (Myf-3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MYOD1 in