DegronMD

Uniprot ID: P15172

Source protein: Myoblast determination protein 1

Source gene: MYOD1

Class: CBL_PTK

Location: 208:217

E3 ligase: CBL

DEGRON score: 0.9711

ASA_SCORE: 60.42

COIL: 0.7662

CONS_SCORE: 0.4908

DSS_SCORE: 0.5632

HELIX: 0.0966

FCONS_SCORE: 0.93

RIG_SCORE: 0.6066

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P202Q	TCGA-55-6981	LUAD	TCGA	DGMMDYSGPP	CBL_PTK	0.1667
p.P202Q	DO24265	LUAD	ICGC	DGMMDYSGPP	CBL_PTK	0.1667
p.P216T	TCGA-94-8035	LUSC	TCGA	DGMMDYSGPP	CBL_PTK	0.5919
p.P216T	DO219173	LUSC	ICGC	DGMMDYSGPP	CBL_PTK	0.5919
p.A220T	TCGA-AU-6004	COAD	TCGA	DGMMDYSGPP	CBL_PTK	0.25
p.A220T	DO7780	COAD	ICGC	DGMMDYSGPP	CBL_PTK	0.25
p.S218R	TCGA-DD-A3A7	LIHC	TCGA	DGMMDYSGPP	CBL_PTK	0.3056
p.S218R	DO44982	LIHC	ICGC	DGMMDYSGPP	CBL_PTK	0.3056
p.S218R	ACH-002287	Colon/Colorectal Cancer	CCLE	DGMMDYSGPP	CBL_PTK	0.3056
p.S218R	NCI-H630	large_intestine	COSMIC	DGMMDYSGPP	CBL_PTK	0.3056
p.R221W	TCGA-FI-A2D5	UCEC	TCGA	DGMMDYSGPP	CBL_PTK	0.2222
p.R221W	DO234462	ESAD	ICGC	DGMMDYSGPP	CBL_PTK	0.2222
p.R221W	DO41331	UCEC	ICGC	DGMMDYSGPP	CBL_PTK	0.2222
p.R223W	TCGA-SL-A6JA	UCEC	TCGA	DGMMDYSGPP	CBL_PTK	0.1667
p.R223W	DO219787	UCEC	ICGC	DGMMDYSGPP	CBL_PTK	0.1667
p.R203L	DO233641	GACA	ICGC	DGMMDYSGPP	CBL_PTK	0.1944
p.N224D	DO233935	GACA	ICGC	DGMMDYSGPP	CBL_PTK	0.1389
p.C206R	DO228338	MALY	ICGC	DGMMDYSGPP	CBL_PTK	0.2778
p.C206R	SIDM00948	Burkitt's Lymphoma	GDSC	DGMMDYSGPP	CBL_PTK	0.2778
p.C206R	ACH-002232	Lymphoma	CCLE	DGMMDYSGPP	CBL_PTK	0.2778
p.C206R	DG-75	haematopoietic_and_lymphoid_tissue	COSMIC	DGMMDYSGPP	CBL_PTK	0.2778
p.M211I	SIDM01274	Esophageal Carcinoma	GDSC	DGMMDYSGPP	CBL_PTK	0.6507
p.G219S	SIDM00449	B-Lymphoblastic Leukemia	GDSC	DGMMDYSGPP	CBL_PTK	0.2778
p.G219S	ACH-000922	Leukemia	CCLE	DGMMDYSGPP	CBL_PTK	0.2778
p.G219S	RCH-ACV	haematopoietic_and_lymphoid_tissue	COSMIC	DGMMDYSGPP	CBL_PTK	0.2778
p.A199V	SIDM00444	Esophageal Carcinoma	GDSC	DGMMDYSGPP	CBL_PTK	0.0833
p.A199V	ACH-001368	Esophageal Cancer	CCLE	DGMMDYSGPP	CBL_PTK	0.0833
p.A199V	OACM5-1	oesophagus	COSMIC	DGMMDYSGPP	CBL_PTK	0.0833
p.P202L	SIDM00498	Colorectal Carcinoma	GDSC	DGMMDYSGPP	CBL_PTK	0.1667
p.P202L	ACH-000970	Colon/Colorectal Cancer	CCLE	DGMMDYSGPP	CBL_PTK	0.1667
p.P202L	SNU-C5	large_intestine	COSMIC	DGMMDYSGPP	CBL_PTK	0.1667
p.R223Q	SIDM00951	T-Lymphoblastic Leukemia	GDSC	DGMMDYSGPP	CBL_PTK	0.1667
p.R223Q	ACH-002222	Leukemia	CCLE	DGMMDYSGPP	CBL_PTK	0.1667
p.R223Q	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	DGMMDYSGPP	CBL_PTK	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DGMMDYSGPP

Degron related mutations and impact score

Drug responses associated with MYOD1 mutations

All proteins holding degron of DGMMDYSGPP

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P15172	Myoblast determination protein 1	CBL_PTK	208:217	DGMMDYSGPP	CBL	0.9711	More...