DegronMD - P15260(IFNGR1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S475F	TCGA-44-2655	LUAD	TCGA	DSGKES	DEG_SCF_TRCP1_1	470:475	Mutation altering degron motif	0.7982
p.S475F	DO23557	LUAD	ICGC	DSGKES	DEG_SCF_TRCP1_1	470:475	Mutation altering degron motif	0.7982
p.E483D	TCGA-A5-A0G2	UCEC	TCGA	DSGKES	DEG_SCF_TRCP1_1	470:475	Mutation rewiring degron network	0.1111
p.E483D	DO41235	UCEC	ICGC	DSGKES	DEG_SCF_TRCP1_1	470:475	Mutation rewiring degron network	0.1111
p.R480I	TCGA-AX-A2HC	UCEC	TCGA	DSGKES	DEG_SCF_TRCP1_1	470:475	Mutation rewiring degron network	0.1944
p.R480I	DO41572	UCEC	ICGC	DSGKES	DEG_SCF_TRCP1_1	470:475	Mutation rewiring degron network	0.1944
p.R480T	TCGA-C5-A1MH	CESC	TCGA	DSGKES	DEG_SCF_TRCP1_1	470:475	Mutation rewiring degron network	0.1944
p.R480T	DO48982	CESC	ICGC	DSGKES	DEG_SCF_TRCP1_1	470:475	Mutation rewiring degron network	0.1944
p.H461Y	TCGA-DI-A1BU	UCEC	TCGA	DSGKES	DEG_SCF_TRCP1_1	470:475	Mutation rewiring degron network	0.0833
p.H461Y	DO42023	UCEC	ICGC	DSGKES	DEG_SCF_TRCP1_1	470:475	Mutation rewiring degron network	0.0833
p.T482I	DO48428	BLCA	ICGC	DSGKES	DEG_SCF_TRCP1_1	470:475	Mutation rewiring degron network	0.1389
p.L467P	DO228483	BRCA	ICGC	DSGKES	DEG_SCF_TRCP1_1	470:475	Mutation rewiring degron network	0.25
p.E474K	SIDM00534	Colorectal Carcinoma	GDSC	DSGKES	DEG_SCF_TRCP1_1	470:475	Mutation altering degron motif	0.591
p.E474K	ACH-000986	Colon/Colorectal Cancer	CCLE	DSGKES	DEG_SCF_TRCP1_1	470:475	Mutation altering degron motif	0.591
p.E474K	HT-115	large intestine	COSMIC	DSGKES	DEG_SCF_TRCP1_1	470:475	Mutation altering degron motif	0.591
p.E464K	HT-115	large intestine	COSMIC	DSGKES	DEG_SCF_TRCP1_1	470:475	Mutation rewiring degron network	0.1667

Kaplan plot for IFNGR1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

IFNGR1

UniProt ID: P15260

Entrez ID: 3459

Protein name: Interferon gamma receptor 1 (IFN-gamma receptor 1) (IFN-gamma-R1) (CDw119) (Interferon gamma receptor alpha-chain) (IFN-gamma-R-alpha) (CD antigen CD119)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for IFNGR1 in