DegronMD

Uniprot ID: P15260

Source protein: Interferon gamma receptor 1

Source gene: IFNGR1

Class: DEG_SCF_TRCP1_1

Location: 470:475

E3 ligase: BTRC

DEGRON score: 0.9462

ASA_SCORE: 84.6333

COIL: 0.7538

CONS_SCORE: 0.4273

DSS_SCORE: 0.287

HELIX: 0.0355

FCONS_SCORE: 0.8132

RIG_SCORE: 0.7489

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S475F	TCGA-44-2655	LUAD	TCGA	DSGKES	DEG_SCF_TRCP1_1	0.7982
p.S475F	DO23557	LUAD	ICGC	DSGKES	DEG_SCF_TRCP1_1	0.7982
p.E483D	TCGA-A5-A0G2	UCEC	TCGA	DSGKES	DEG_SCF_TRCP1_1	0.1111
p.E483D	DO41235	UCEC	ICGC	DSGKES	DEG_SCF_TRCP1_1	0.1111
p.R480I	TCGA-AX-A2HC	UCEC	TCGA	DSGKES	DEG_SCF_TRCP1_1	0.1944
p.R480I	DO41572	UCEC	ICGC	DSGKES	DEG_SCF_TRCP1_1	0.1944
p.R480T	TCGA-C5-A1MH	CESC	TCGA	DSGKES	DEG_SCF_TRCP1_1	0.1944
p.R480T	DO48982	CESC	ICGC	DSGKES	DEG_SCF_TRCP1_1	0.1944
p.H461Y	TCGA-DI-A1BU	UCEC	TCGA	DSGKES	DEG_SCF_TRCP1_1	0.0833
p.H461Y	DO42023	UCEC	ICGC	DSGKES	DEG_SCF_TRCP1_1	0.0833
p.T482I	DO48428	BLCA	ICGC	DSGKES	DEG_SCF_TRCP1_1	0.1389
p.L467P	DO228483	BRCA	ICGC	DSGKES	DEG_SCF_TRCP1_1	0.25
p.E474K	SIDM00534	Colorectal Carcinoma	GDSC	DSGKES	DEG_SCF_TRCP1_1	0.591
p.E474K	ACH-000986	Colon/Colorectal Cancer	CCLE	DSGKES	DEG_SCF_TRCP1_1	0.591
p.E474K	HT-115	large_intestine	COSMIC	DSGKES	DEG_SCF_TRCP1_1	0.591
p.E464K	HT-115	large_intestine	COSMIC	DSGKES	DEG_SCF_TRCP1_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P15260	Interferon gamma receptor 1	DEG_SCF_TRCP1_1	470:475	DSGKES	BTRC	0.9462	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons