DegronMD - P15814(IGLL1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L126I	TCGA-B5-A1MX	UCEC	TCGA	PKATPSVT	DEG_SCF_FBW7_1	110:117	Mutation rewiring degron network	0.0833
p.L126I	DO41999	UCEC	ICGC	PKATPSVT	DEG_SCF_FBW7_1	110:117	Mutation rewiring degron network	0.0833
p.P120T	TCGA-D3-A3C7	SKCM	TCGA	PKATPSVT	DEG_SCF_FBW7_1	110:117	Mutation rewiring degron network	0.25
p.P120T	DO47569	SKCM	ICGC	PKATPSVT	DEG_SCF_FBW7_1	110:117	Mutation rewiring degron network	0.25
p.S115L	TCGA-EB-A24D	SKCM	TCGA	PKATPSVT	DEG_SCF_FBW7_1	110:117	Mutation altering degron motif	0.6556
p.S115L	TCGA-GN-A266	SKCM	TCGA	PKATPSVT	DEG_SCF_FBW7_1	110:117	Mutation altering degron motif	0.6556
p.S115L	TCGA-YG-AA3N	SKCM	TCGA	PKATPSVT	DEG_SCF_FBW7_1	110:117	Mutation altering degron motif	0.6556
p.S115L	DO37432	SKCM	ICGC	PKATPSVT	DEG_SCF_FBW7_1	110:117	Mutation altering degron motif	0.6556
p.S115L	DO37440	SKCM	ICGC	PKATPSVT	DEG_SCF_FBW7_1	110:117	Mutation altering degron motif	0.6556
p.S115L	DO51298	SKCM	ICGC	PKATPSVT	DEG_SCF_FBW7_1	110:117	Mutation altering degron motif	0.6556
p.S122F	TCGA-FR-A3YO	SKCM	TCGA	PKATPSVT	DEG_SCF_FBW7_1	110:117	Mutation rewiring degron network	0.1944
p.S122F	DO37419	SKCM	ICGC	PKATPSVT	DEG_SCF_FBW7_1	110:117	Mutation rewiring degron network	0.1944
p.A112T	DO52481	COCA	ICGC	PKATPSVT	DEG_SCF_FBW7_1	110:117	Mutation altering degron motif	0.6028
p.A112T	SIDM00285	Neuroblastoma	GDSC	PKATPSVT	DEG_SCF_FBW7_1	110:117	Mutation altering degron motif	0.6028
p.A112T	SIDM00826	Colorectal Carcinoma	GDSC	PKATPSVT	DEG_SCF_FBW7_1	110:117	Mutation altering degron motif	0.6028
p.A112T	SIDM00823	Colorectal Carcinoma	GDSC	PKATPSVT	DEG_SCF_FBW7_1	110:117	Mutation altering degron motif	0.6028
p.A112D	DO229019	LICA	ICGC	PKATPSVT	DEG_SCF_FBW7_1	110:117	Mutation altering degron motif	0.6682
p.K111N	DO231155	LUSC	ICGC	PKATPSVT	DEG_SCF_FBW7_1	110:117	Mutation altering degron motif	0.5806
p.K111N	DO42673	UCEC	ICGC	PKATPSVT	DEG_SCF_FBW7_1	110:117	Mutation altering degron motif	0.5806
p.E124G	SIDM01007	T-Lymphoblastic Leukemia	GDSC	PKATPSVT	DEG_SCF_FBW7_1	110:117	Mutation rewiring degron network	0.1389
p.E124G	ACH-002256	Leukemia	CCLE	PKATPSVT	DEG_SCF_FBW7_1	110:117	Mutation rewiring degron network	0.1389
p.E124G	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	PKATPSVT	DEG_SCF_FBW7_1	110:117	Mutation rewiring degron network	0.1389
p.V106F	SIDM00589	Oral Cavity Carcinoma	GDSC	PKATPSVT	DEG_SCF_FBW7_1	110:117	Mutation rewiring degron network	0.2222
p.V106F	ACH-000778	Head and Neck Cancer	CCLE	PKATPSVT	DEG_SCF_FBW7_1	110:117	Mutation rewiring degron network	0.2222
p.V106F	HSC-3	upper aerodigestive tract	COSMIC	PKATPSVT	DEG_SCF_FBW7_1	110:117	Mutation rewiring degron network	0.2222
p.S115T	ACH-000745	Myeloma	CCLE	PKATPSVT	DEG_SCF_FBW7_1	110:117	Mutation altering degron motif	0.6005
p.T113N	ACH-000745	Myeloma	CCLE	PKATPSVT	DEG_SCF_FBW7_1	110:117	Mutation altering degron motif	0.7055

Kaplan plot for IGLL1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

IGLL1

UniProt ID: P15814

Entrez ID: 3543

Protein name: Immunoglobulin lambda-like polypeptide 1 (CD179 antigen-like family member B) (Ig lambda-5) (Immunoglobulin omega polypeptide) (Immunoglobulin-related protein 14.1) (CD antigen CD179b)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for IGLL1 in