DegronMD

Uniprot ID: P15814

Source protein: Immunoglobulin lambda-like polypeptide 1

Source gene: IGLL1

Class: DEG_SCF_FBW7_1

Location: 110:117

E3 ligase: FBXW7

DEGRON score: 0.8802

ASA_SCORE: 61.3375

COIL: 0.6694

CONS_SCORE: 0.6454

DSS_SCORE: 0.4309

HELIX: 0.0156

FCONS_SCORE: 0.9221

RIG_SCORE: 0.7218

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L126I	TCGA-B5-A1MX	UCEC	TCGA	PKATPSVT	DEG_SCF_FBW7_1	0.0833
p.L126I	DO41999	UCEC	ICGC	PKATPSVT	DEG_SCF_FBW7_1	0.0833
p.P120T	TCGA-D3-A3C7	SKCM	TCGA	PKATPSVT	DEG_SCF_FBW7_1	0.25
p.P120T	DO47569	SKCM	ICGC	PKATPSVT	DEG_SCF_FBW7_1	0.25
p.S115L	TCGA-EB-A24D	SKCM	TCGA	PKATPSVT	DEG_SCF_FBW7_1	0.6556
p.S115L	TCGA-GN-A266	SKCM	TCGA	PKATPSVT	DEG_SCF_FBW7_1	0.6556
p.S115L	TCGA-YG-AA3N	SKCM	TCGA	PKATPSVT	DEG_SCF_FBW7_1	0.6556
p.S115L	DO37432	SKCM	ICGC	PKATPSVT	DEG_SCF_FBW7_1	0.6556
p.S115L	DO37440	SKCM	ICGC	PKATPSVT	DEG_SCF_FBW7_1	0.6556
p.S115L	DO51298	SKCM	ICGC	PKATPSVT	DEG_SCF_FBW7_1	0.6556
p.S122F	TCGA-FR-A3YO	SKCM	TCGA	PKATPSVT	DEG_SCF_FBW7_1	0.1944
p.S122F	DO37419	SKCM	ICGC	PKATPSVT	DEG_SCF_FBW7_1	0.1944
p.A112T	DO52481	COCA	ICGC	PKATPSVT	DEG_SCF_FBW7_1	0.6028
p.A112T	SIDM00285	Neuroblastoma	GDSC	PKATPSVT	DEG_SCF_FBW7_1	0.6028
p.A112T	SIDM00826	Colorectal Carcinoma	GDSC	PKATPSVT	DEG_SCF_FBW7_1	0.6028
p.A112T	SIDM00823	Colorectal Carcinoma	GDSC	PKATPSVT	DEG_SCF_FBW7_1	0.6028
p.A112D	DO229019	LICA	ICGC	PKATPSVT	DEG_SCF_FBW7_1	0.6682
p.K111N	DO231155	LUSC	ICGC	PKATPSVT	DEG_SCF_FBW7_1	0.5806
p.K111N	DO42673	UCEC	ICGC	PKATPSVT	DEG_SCF_FBW7_1	0.5806
p.E124G	SIDM01007	T-Lymphoblastic Leukemia	GDSC	PKATPSVT	DEG_SCF_FBW7_1	0.1389
p.E124G	ACH-002256	Leukemia	CCLE	PKATPSVT	DEG_SCF_FBW7_1	0.1389
p.E124G	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	PKATPSVT	DEG_SCF_FBW7_1	0.1389
p.V106F	SIDM00589	Oral Cavity Carcinoma	GDSC	PKATPSVT	DEG_SCF_FBW7_1	0.2222
p.V106F	ACH-000778	Head and Neck Cancer	CCLE	PKATPSVT	DEG_SCF_FBW7_1	0.2222
p.V106F	HSC-3	upper_aerodigestive_tract	COSMIC	PKATPSVT	DEG_SCF_FBW7_1	0.2222
p.S115T	ACH-000745	Myeloma	CCLE	PKATPSVT	DEG_SCF_FBW7_1	0.6005
p.T113N	ACH-000745	Myeloma	CCLE	PKATPSVT	DEG_SCF_FBW7_1	0.7055

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P15814	Immunoglobulin lambda-like polypeptide 1	DEG_SCF_FBW7_1	110:117	PKATPSVT	FBXW7	0.8802	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PKATPSVT

Degron related mutations and impact score

Drug responses associated with IGLL1 mutations

All proteins holding degron of PKATPSVT