DegronMD - P15848(ARSB)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V23I	DO233273	GACA	ICGC	PRRLLLPVV	DEG_APCC_DBOX_1	15:23	Mutation altering degron motif	0.5965
p.P25Q	DO228349	MALY	ICGC	PRRLLLPVV	DEG_APCC_DBOX_1	15:23	Mutation rewiring degron network	0.2778
p.R16Q	DO229275	THCA	ICGC	PRRLLLPVV	DEG_APCC_DBOX_1	15:23	Mutation altering degron motif	0.7329
p.P21S	DO229234	THCA	ICGC	PRRLLLPVV	DEG_APCC_DBOX_1	15:23	Mutation altering degron motif	0.5641
p.V22I	DO229089	THCA	ICGC	PRRLLLPVV	DEG_APCC_DBOX_1	15:23	Mutation altering degron motif	0.5965
p.A33V	SIDM01057	Acute Myeloid Leukemia	GDSC	PRRLLLPVV	DEG_APCC_DBOX_1	15:23	Mutation rewiring degron network	0.0556
p.A33V	SIDM00831	Head and Neck Carcinoma	GDSC	PRRLLLPVV	DEG_APCC_DBOX_1	15:23	Mutation rewiring degron network	0.0556
p.A33V	SIDM00042	Pancreatic Carcinoma	GDSC	PRRLLLPVV	DEG_APCC_DBOX_1	15:23	Mutation rewiring degron network	0.0556
p.A33V	SIDM00269	Ewing's Sarcoma	GDSC	PRRLLLPVV	DEG_APCC_DBOX_1	15:23	Mutation rewiring degron network	0.0556
p.A33V	SIDM00310	Mesothelioma	GDSC	PRRLLLPVV	DEG_APCC_DBOX_1	15:23	Mutation rewiring degron network	0.0556
p.A33V	SIDM00462	Acute Myeloid Leukemia	GDSC	PRRLLLPVV	DEG_APCC_DBOX_1	15:23	Mutation rewiring degron network	0.0556
p.A33V	SIDM00920	Breast Carcinoma	GDSC	PRRLLLPVV	DEG_APCC_DBOX_1	15:23	Mutation rewiring degron network	0.0556
p.A33V	SIDM00726	Non-Small Cell Lung Carcinoma	GDSC	PRRLLLPVV	DEG_APCC_DBOX_1	15:23	Mutation rewiring degron network	0.0556
p.A33V	SIDM00124	Kidney Carcinoma	GDSC	PRRLLLPVV	DEG_APCC_DBOX_1	15:23	Mutation rewiring degron network	0.0556
p.A33V	SIDM01246	Ewing's Sarcoma	GDSC	PRRLLLPVV	DEG_APCC_DBOX_1	15:23	Mutation rewiring degron network	0.0556

Kaplan plot for ARSB in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ARSB

UniProt ID: P15848

Entrez ID: 411

Protein name: Arylsulfatase B (ASB) (EC 3.1.6.12) (N-acetylgalactosamine-4-sulfatase) (G4S)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ARSB in