DegronMD

Uniprot ID: P15848

Source protein: Arylsulfatase B

Source gene: ARSB

Class: DEG_APCC_DBOX_1

Location: 15:23

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6508

ASA_SCORE: 80.9222

COIL: 0.2966

CONS_SCORE: 0.286

DSS_SCORE: 0.0845

HELIX: 0.6814

FCONS_SCORE: 1.2324

RIG_SCORE: 0.8293

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V23I	DO233273	GACA	ICGC	PRRLLLPVV	DEG_APCC_DBOX_1	0.5965
p.P25Q	DO228349	MALY	ICGC	PRRLLLPVV	DEG_APCC_DBOX_1	0.2778
p.R16Q	DO229275	THCA	ICGC	PRRLLLPVV	DEG_APCC_DBOX_1	0.7329
p.P21S	DO229234	THCA	ICGC	PRRLLLPVV	DEG_APCC_DBOX_1	0.5641
p.V22I	DO229089	THCA	ICGC	PRRLLLPVV	DEG_APCC_DBOX_1	0.5965
p.A33V	SIDM01057	Acute Myeloid Leukemia	GDSC	PRRLLLPVV	DEG_APCC_DBOX_1	0.0556
p.A33V	SIDM00831	Head and Neck Carcinoma	GDSC	PRRLLLPVV	DEG_APCC_DBOX_1	0.0556
p.A33V	SIDM00042	Pancreatic Carcinoma	GDSC	PRRLLLPVV	DEG_APCC_DBOX_1	0.0556
p.A33V	SIDM00269	Ewing's Sarcoma	GDSC	PRRLLLPVV	DEG_APCC_DBOX_1	0.0556
p.A33V	SIDM00310	Mesothelioma	GDSC	PRRLLLPVV	DEG_APCC_DBOX_1	0.0556
p.A33V	SIDM00462	Acute Myeloid Leukemia	GDSC	PRRLLLPVV	DEG_APCC_DBOX_1	0.0556
p.A33V	SIDM00920	Breast Carcinoma	GDSC	PRRLLLPVV	DEG_APCC_DBOX_1	0.0556
p.A33V	SIDM00726	Non-Small Cell Lung Carcinoma	GDSC	PRRLLLPVV	DEG_APCC_DBOX_1	0.0556
p.A33V	SIDM00124	Kidney Carcinoma	GDSC	PRRLLLPVV	DEG_APCC_DBOX_1	0.0556
p.A33V	SIDM01246	Ewing's Sarcoma	GDSC	PRRLLLPVV	DEG_APCC_DBOX_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P15848	Arylsulfatase B	DEG_APCC_DBOX_1	15:23	PRRLLLPVV	APC,CDC20,FZR1	0.6508	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons