DegronMD - P15907(ST6GAL1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R75C	TCGA-86-A4JF	LUAD	TCGA	GRQTLGSLR	DEG_APCC_DBOX_1	74:82	Mutation altering degron motif	0.8301
p.R75C	TCGA-B5-A11E	UCEC	TCGA	GRQTLGSLR	DEG_APCC_DBOX_1	74:82	Mutation altering degron motif	0.8301
p.R75C	DO45317	LUAD	ICGC	GRQTLGSLR	DEG_APCC_DBOX_1	74:82	Mutation altering degron motif	0.8301
p.R75C	DO41644	UCEC	ICGC	GRQTLGSLR	DEG_APCC_DBOX_1	74:82	Mutation altering degron motif	0.8301
p.P71S	TCGA-CV-7568	HNSC	TCGA	GRQTLGSLR	DEG_APCC_DBOX_1	74:82	Mutation rewiring degron network	0.25
p.P71S	DO14160	HNSC	ICGC	GRQTLGSLR	DEG_APCC_DBOX_1	74:82	Mutation rewiring degron network	0.25
p.T68I	TCGA-EE-A2GO	SKCM	TCGA	GRQTLGSLR	DEG_APCC_DBOX_1	74:82	Mutation rewiring degron network	0.1667
p.T68I	DO37823	SKCM	ICGC	GRQTLGSLR	DEG_APCC_DBOX_1	74:82	Mutation rewiring degron network	0.1667
p.G79V	TCGA-GV-A3QK	BLCA	TCGA	GRQTLGSLR	DEG_APCC_DBOX_1	74:82	Mutation altering degron motif	0.6421
p.G79V	DO563	BLCA	ICGC	GRQTLGSLR	DEG_APCC_DBOX_1	74:82	Mutation altering degron motif	0.6421
p.S80G	TCGA-XF-AAMX	BLCA	TCGA	GRQTLGSLR	DEG_APCC_DBOX_1	74:82	Mutation altering degron motif	0.6993
p.S80G	DO51939	BLCA	ICGC	GRQTLGSLR	DEG_APCC_DBOX_1	74:82	Mutation altering degron motif	0.6993
p.K88Q	SIDM01193	Glioma	GDSC	GRQTLGSLR	DEG_APCC_DBOX_1	74:82	Mutation substituting flanking lysine	0.2778
p.K88Q	ACH-000040	Brain Cancer	CCLE	GRQTLGSLR	DEG_APCC_DBOX_1	74:82	Mutation substituting flanking lysine	0.2778
p.K88Q	U-118-MG	central nervous system	COSMIC	GRQTLGSLR	DEG_APCC_DBOX_1	74:82	Mutation substituting flanking lysine	0.2778
p.A85V	SIDM00448	B-Cell Non-Hodgkin's Lymphoma	GDSC	GRQTLGSLR	DEG_APCC_DBOX_1	74:82	Mutation rewiring degron network	0.25
p.A85V	ACH-001638	Lymphoma	CCLE	GRQTLGSLR	DEG_APCC_DBOX_1	74:82	Mutation rewiring degron network	0.25
p.A85V	RC-K8	haematopoietic and lymphoid tissue	COSMIC	GRQTLGSLR	DEG_APCC_DBOX_1	74:82	Mutation rewiring degron network	0.25
p.S80N	SIDM00257	Neuroblastoma	GDSC	GRQTLGSLR	DEG_APCC_DBOX_1	74:82	Mutation altering degron motif	0.7069
p.S80N	ACH-002280	Neuroblastoma	CCLE	GRQTLGSLR	DEG_APCC_DBOX_1	74:82	Mutation altering degron motif	0.7069
p.S80N	NB13	autonomic ganglia	COSMIC	GRQTLGSLR	DEG_APCC_DBOX_1	74:82	Mutation altering degron motif	0.7069
p.G79S	SIDM00628	Breast Carcinoma	GDSC	GRQTLGSLR	DEG_APCC_DBOX_1	74:82	Mutation altering degron motif	0.5882
p.A87T	SIDM01608	Endometrial Carcinoma	GDSC	GRQTLGSLR	DEG_APCC_DBOX_1	74:82	Mutation rewiring degron network	0.1944
p.A87T	ACH-000990	Endometrial/Uterine Cancer	CCLE	GRQTLGSLR	DEG_APCC_DBOX_1	74:82	Mutation rewiring degron network	0.1944
p.G74D	ACH-000954	Endometrial/Uterine Cancer	CCLE	GRQTLGSLR	DEG_APCC_DBOX_1	74:82	Mutation altering degron motif	0.6087
p.I85S	NCI-H847	lung	COSMIC	GRQTLGSLR	DEG_APCC_DBOX_1	74:82	Mutation rewiring degron network	0.25
p.W74C	EN	endometrium	COSMIC	GRQTLGSLR	DEG_APCC_DBOX_1	74:82	Mutation altering degron motif	0.7

Kaplan plot for ST6GAL1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ST6GAL1

UniProt ID: P15907

Entrez ID: 6480

Protein name: Beta-galactoside alpha-2,6-sialyltransferase 1 (Alpha 2,6-ST 1) (EC 2.4.99.1) (B-cell antigen CD75) (CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 1) (ST6Gal I) (ST6GalI) (Sialyltransferase 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ST6GAL1 in