DegronMD

Uniprot ID: P15907

Source protein: Beta-galactoside alpha-2,6-sialyltransferase 1

Source gene: ST6GAL1

Class: DEG_APCC_DBOX_1

Location: 74:82

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9746

ASA_SCORE: 85.0222

COIL: 0.7057

CONS_SCORE: 0.2827

DSS_SCORE: 0.6646

HELIX: 0.1793

FCONS_SCORE: 1.0559

RIG_SCORE: 0.6765

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R75C	TCGA-86-A4JF	LUAD	TCGA	GRQTLGSLR	DEG_APCC_DBOX_1	0.8301
p.R75C	TCGA-B5-A11E	UCEC	TCGA	GRQTLGSLR	DEG_APCC_DBOX_1	0.8301
p.R75C	DO45317	LUAD	ICGC	GRQTLGSLR	DEG_APCC_DBOX_1	0.8301
p.R75C	DO41644	UCEC	ICGC	GRQTLGSLR	DEG_APCC_DBOX_1	0.8301
p.P71S	TCGA-CV-7568	HNSC	TCGA	GRQTLGSLR	DEG_APCC_DBOX_1	0.25
p.P71S	DO14160	HNSC	ICGC	GRQTLGSLR	DEG_APCC_DBOX_1	0.25
p.T68I	TCGA-EE-A2GO	SKCM	TCGA	GRQTLGSLR	DEG_APCC_DBOX_1	0.1667
p.T68I	DO37823	SKCM	ICGC	GRQTLGSLR	DEG_APCC_DBOX_1	0.1667
p.G79V	TCGA-GV-A3QK	BLCA	TCGA	GRQTLGSLR	DEG_APCC_DBOX_1	0.6421
p.G79V	DO563	BLCA	ICGC	GRQTLGSLR	DEG_APCC_DBOX_1	0.6421
p.S80G	TCGA-XF-AAMX	BLCA	TCGA	GRQTLGSLR	DEG_APCC_DBOX_1	0.6993
p.S80G	DO51939	BLCA	ICGC	GRQTLGSLR	DEG_APCC_DBOX_1	0.6993
p.K88Q	SIDM01193	Glioma	GDSC	GRQTLGSLR	DEG_APCC_DBOX_1	0.2778
p.K88Q	ACH-000040	Brain Cancer	CCLE	GRQTLGSLR	DEG_APCC_DBOX_1	0.2778
p.K88Q	U-118-MG	central_nervous_system	COSMIC	GRQTLGSLR	DEG_APCC_DBOX_1	0.2778
p.A85V	SIDM00448	B-Cell Non-Hodgkin's Lymphoma	GDSC	GRQTLGSLR	DEG_APCC_DBOX_1	0.25
p.A85V	ACH-001638	Lymphoma	CCLE	GRQTLGSLR	DEG_APCC_DBOX_1	0.25
p.A85V	RC-K8	haematopoietic_and_lymphoid_tissue	COSMIC	GRQTLGSLR	DEG_APCC_DBOX_1	0.25
p.S80N	SIDM00257	Neuroblastoma	GDSC	GRQTLGSLR	DEG_APCC_DBOX_1	0.7069
p.S80N	ACH-002280	Neuroblastoma	CCLE	GRQTLGSLR	DEG_APCC_DBOX_1	0.7069
p.S80N	NB13	autonomic_ganglia	COSMIC	GRQTLGSLR	DEG_APCC_DBOX_1	0.7069
p.G79S	SIDM00628	Breast Carcinoma	GDSC	GRQTLGSLR	DEG_APCC_DBOX_1	0.5882
p.A87T	SIDM01608	Endometrial Carcinoma	GDSC	GRQTLGSLR	DEG_APCC_DBOX_1	0.1944
p.A87T	ACH-000990	Endometrial/Uterine Cancer	CCLE	GRQTLGSLR	DEG_APCC_DBOX_1	0.1944
p.G74D	ACH-000954	Endometrial/Uterine Cancer	CCLE	GRQTLGSLR	DEG_APCC_DBOX_1	0.6087
p.I85S	NCI-H847	lung	COSMIC	GRQTLGSLR	DEG_APCC_DBOX_1	0.25
p.W74C	EN	endometrium	COSMIC	GRQTLGSLR	DEG_APCC_DBOX_1	0.7

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: GRQTLGSLR

Degron related mutations and impact score

Drug responses associated with ST6GAL1 mutations

All proteins holding degron of GRQTLGSLR

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P15907	Beta-galactoside alpha-2,6-sialyltransferase 1	DEG_APCC_DBOX_1	74:82	GRQTLGSLR	APC,CDC20,FZR1	0.9746	More...