DegronMD - P16157(ANK1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R1498H	TCGA-61-2002	OV	TCGA	DRDYSLSP	CBL_PTK	1501:1508	Mutation rewiring degron network	0.25
p.R1498H	TCGA-CS-6665	LGG	TCGA	DRDYSLSP	CBL_PTK	1501:1508	Mutation rewiring degron network	0.25
p.T1510I	TCGA-A6-3809	COAD	TCGA	DRDYSLSP	CBL_PTK	1501:1508	Mutation rewiring degron network	0.2778
p.G1518D	TCGA-AJ-A8CW	UCEC	TCGA	DRDYSLSP	CBL_PTK	1501:1508	Mutation rewiring degron network	0.0556
p.R1498C	TCGA-B5-A1MX	UCEC	TCGA	DRDYSLSP	CBL_PTK	1501:1508	Mutation rewiring degron network	0.25
p.R1498C	TCGA-CV-7424	HNSC	TCGA	DRDYSLSP	CBL_PTK	1501:1508	Mutation rewiring degron network	0.25
p.N1492K	DO229022	LICA	ICGC	DRDYSLSP	CBL_PTK	1501:1508	Mutation rewiring degron network	0.0833
p.P1508T	DO25426	LUAD	ICGC	DRDYSLSP	CBL_PTK	1501:1508	Mutation altering degron motif	0.7031
p.Q1510H	DO36752	READ	ICGC	DRDYSLSP	CBL_PTK	1501:1508	Mutation rewiring degron network	0.2778
p.P1508L	DO218847	SKCA	ICGC	DRDYSLSP	CBL_PTK	1501:1508	Mutation altering degron motif	0.7582
p.D1501N	DO38887	STAD	ICGC	DRDYSLSP	CBL_PTK	1501:1508	Mutation altering degron motif	0.5821
p.D1501N	DO51751	STAD	ICGC	DRDYSLSP	CBL_PTK	1501:1508	Mutation altering degron motif	0.5821
p.R1517H	SIDM01154	T-Lymphoblastic Leukemia	GDSC	DRDYSLSP	CBL_PTK	1501:1508	Mutation rewiring degron network	0.0833
p.R1517H	SUP-T1	haematopoietic and lymphoid tissue	COSMIC	DRDYSLSP	CBL_PTK	1501:1508	Mutation rewiring degron network	0.0833
p.R1491G	ACH-000843	Lung Cancer	CCLE	DRDYSLSP	CBL_PTK	1501:1508	Mutation rewiring degron network	0.0556
p.R1491G	HARA	lung	COSMIC	DRDYSLSP	CBL_PTK	1501:1508	Mutation rewiring degron network	0.0556
p.R1502H	ACH-000999	Colon/Colorectal Cancer	CCLE	DRDYSLSP	CBL_PTK	1501:1508	Mutation altering degron motif	0.7133
p.R1502H	SNU-1040	large intestine	COSMIC	DRDYSLSP	CBL_PTK	1501:1508	Mutation altering degron motif	0.7133

Kaplan plot for ANK1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ANK1

UniProt ID: P16157

Entrez ID: 286

Protein name: Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ANK1 in