DegronMD

Uniprot ID: P16157

Source protein: Ankyrin-1

Source gene: ANK1

Class: CBL_PTK

Location: 1501:1508

E3 ligase: CBL

DEGRON score: 0.9865

ASA_SCORE: 86.1625

COIL: 0.7575

CONS_SCORE: 0.3562

DSS_SCORE: 0.644

HELIX: 0.1625

FCONS_SCORE: 1.1359

RIG_SCORE: 0.688

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1498H	TCGA-61-2002	OV	TCGA	DRDYSLSP	CBL_PTK	0.25
p.R1498H	TCGA-CS-6665	LGG	TCGA	DRDYSLSP	CBL_PTK	0.25
p.T1510I	TCGA-A6-3809	COAD	TCGA	DRDYSLSP	CBL_PTK	0.2778
p.G1518D	TCGA-AJ-A8CW	UCEC	TCGA	DRDYSLSP	CBL_PTK	0.0556
p.R1498C	TCGA-B5-A1MX	UCEC	TCGA	DRDYSLSP	CBL_PTK	0.25
p.R1498C	TCGA-CV-7424	HNSC	TCGA	DRDYSLSP	CBL_PTK	0.25
p.N1492K	DO229022	LICA	ICGC	DRDYSLSP	CBL_PTK	0.0833
p.P1508T	DO25426	LUAD	ICGC	DRDYSLSP	CBL_PTK	0.7031
p.Q1510H	DO36752	READ	ICGC	DRDYSLSP	CBL_PTK	0.2778
p.P1508L	DO218847	SKCA	ICGC	DRDYSLSP	CBL_PTK	0.7582
p.D1501N	DO38887	STAD	ICGC	DRDYSLSP	CBL_PTK	0.5821
p.D1501N	DO51751	STAD	ICGC	DRDYSLSP	CBL_PTK	0.5821
p.R1517H	SIDM01154	T-Lymphoblastic Leukemia	GDSC	DRDYSLSP	CBL_PTK	0.0833
p.R1517H	SUP-T1	haematopoietic_and_lymphoid_tissue	COSMIC	DRDYSLSP	CBL_PTK	0.0833
p.R1491G	ACH-000843	Lung Cancer	CCLE	DRDYSLSP	CBL_PTK	0.0556
p.R1491G	HARA	lung	COSMIC	DRDYSLSP	CBL_PTK	0.0556
p.R1502H	ACH-000999	Colon/Colorectal Cancer	CCLE	DRDYSLSP	CBL_PTK	0.7133
p.R1502H	SNU-1040	large_intestine	COSMIC	DRDYSLSP	CBL_PTK	0.7133

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P16157	Ankyrin-1	CBL_PTK	1501:1508	DRDYSLSP	CBL	0.9865	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons