PECAM1
UniProt ID: P16284
Entrez ID: 5175
Protein name: Platelet endothelial cell adhesion molecule (PECAM-1) (EndoCAM) (GPIIA') (PECA1) (CD antigen CD31)
External links: UniprotKB HGNC RefSeq COSMIC
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FUNCTION: Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions (PubMed:19342684, PubMed:17580308). Tyr-690 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling c...
FUNCTION: Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions (PubMed:19342684, PubMed:17580308). Tyr-690 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes (PubMed:19342684). Trans-homophilic interaction may play a role in endothelial cell-cell adhesion via cell junctions (PubMed:27958302). Heterophilic interaction with CD177 plays a role in transendothelial migration of neutrophils (PubMed:17580308). Homophilic ligation of PECAM1 prevents macrophage-mediated phagocytosis of neighboring viable leukocytes by transmitting a detachment signal (PubMed:12110892). Promotes macrophage-mediated phagocytosis of apoptotic leukocytes by tethering them to the phagocytic cells; PECAM1-mediated detachment signal appears to be disabled in apoptotic leukocytes (PubMed:12110892). Modulates bradykinin receptor BDKRB2 activation (PubMed:18672896). Regulates bradykinin- and hyperosmotic shock-induced ERK1/2 activation in endothelial cells (PubMed:18672896). Induces susceptibility to atherosclerosis (By similarity). {ECO:0000250|UniProtKB:Q08481, ECO:0000269|PubMed:12110892, ECO:0000269|PubMed:17580308, ECO:0000269|PubMed:18672896, ECO:0000269|PubMed:19342684, ECO:0000269|PubMed:27958302}.; FUNCTION: [Isoform Delta15]: Does not protect against apoptosis. {ECO:0000269|PubMed:18388311}.
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GO - Biological processes (BP):
bicellular tight junction assembly [GO:0070830]; cell-cell adhesion [GO:0098609]; cell-cell adhesion via plasma-membrane adhesion molecules [GO:0098742]; cell recognition [GO:0008037]; cell surface receptor signaling pathway [GO:0007166]; diapedesis [GO:0050904]; establishment of endothelial barrier...
bicellular tight junction assembly [GO:0070830]; cell-cell adhesion [GO:0098609]; cell-cell adhesion via plasma-membrane adhesion molecules [GO:0098742]; cell recognition [GO:0008037]; cell surface receptor signaling pathway [GO:0007166]; diapedesis [GO:0050904]; establishment of endothelial barrier [GO:0061028]; glomerular endothelium development [GO:0072011]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; leukocyte cell-cell adhesion [GO:0007159]; maintenance of blood-brain barrier [GO:0035633]; monocyte extravasation [GO:0035696]; neutrophil extravasation [GO:0072672]; phagocytosis [GO:0006909]; positive regulation of cell migration [GO:0030335]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of protein localization to cell-cell junction [GO:0150107]; positive regulation of protein phosphorylation [GO:0001934]; signal transduction [GO:0007165]
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GO - Molecular function (MF):
protein homodimerization activity [GO:0042803]; transmembrane signaling receptor activity [GO:0004888]...
protein homodimerization activity [GO:0042803]; transmembrane signaling receptor activity [GO:0004888]
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GO - Cellular component (CC):
cell-cell junction [GO:0005911]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; integral component of plasma membrane [GO:0005887]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; platelet alpha granule membrane [GO:0031092]; protein-containing complex [GO:0032991]; ...
cell-cell junction [GO:0005911]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; integral component of plasma membrane [GO:0005887]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; platelet alpha granule membrane [GO:0031092]; protein-containing complex [GO:0032991]; secretory granule membrane [GO:0030667]
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PECAM1
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Kaplan plot for PECAM1 in
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*NOTE: the Kaplan plots were collected from OncoLnc