DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
LAPWKKGLIAVVII
Uniprot ID:
P16284
Source protein:
Platelet endothelial cell adhesion molecule
Source gene:
PECAM1
Class:
DEG_ODPH_VHL_1
Location:
596:609
E3 ligase:
VHL
DEGRON score:
0.9293
ASA_SCORE:
75.7643
COIL:
0.5246
CONS_SCORE:
0.7448
DSS_SCORE:
0.0006
HELIX:
0.3091
FCONS_SCORE:
1.3712
RIG_SCORE:
1.0277
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.V594G
SIDM02057
Colorectal Carcinoma
GDSC
LAPWKKGLIAVVII
DEG_ODPH_VHL_1
0.2778
p.W599R
SIDM02041
Colorectal Carcinoma
GDSC
LAPWKKGLIAVVII
DEG_ODPH_VHL_1
0.7523
Drug responses associated with PECAM1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LAPWKKGLIAVVII
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P16284
Platelet endothelial cell adhesion molecule
DEG_ODPH_VHL_1
596:609
LAPWKKGLIAVVII
VHL
0.9293
More...