DegronMD - P16402(H1-3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A15T	SIDM00588	Oral Cavity Carcinoma	GDSC	PAEKTPVK	DEG_SCF_SKP2-CKS1_1	14:21	Mutation altering degron motif	0.6028
p.A15T	SIDM00437	Acute Myeloid Leukemia	GDSC	PAEKTPVK	DEG_SCF_SKP2-CKS1_1	14:21	Mutation altering degron motif	0.6028
p.A15T	SIDM00577	Neuroblastoma	GDSC	PAEKTPVK	DEG_SCF_SKP2-CKS1_1	14:21	Mutation altering degron motif	0.6028
p.A15T	SIDM01028	Esophageal Squamous Cell Carcinoma	GDSC	PAEKTPVK	DEG_SCF_SKP2-CKS1_1	14:21	Mutation altering degron motif	0.6028
p.A15T	SIDM00573	Glioblastoma	GDSC	PAEKTPVK	DEG_SCF_SKP2-CKS1_1	14:21	Mutation altering degron motif	0.6028
p.A15T	SIDM00687	Gastric Carcinoma	GDSC	PAEKTPVK	DEG_SCF_SKP2-CKS1_1	14:21	Mutation altering degron motif	0.6028
p.A15T	SIDM00250	Esophageal Squamous Cell Carcinoma	GDSC	PAEKTPVK	DEG_SCF_SKP2-CKS1_1	14:21	Mutation altering degron motif	0.6028
p.A15T	SIDM00247	Gastric Carcinoma	GDSC	PAEKTPVK	DEG_SCF_SKP2-CKS1_1	14:21	Mutation altering degron motif	0.6028
p.A15T	SIDM00302	Other Solid Cancers	GDSC	PAEKTPVK	DEG_SCF_SKP2-CKS1_1	14:21	Mutation altering degron motif	0.6028
p.A15T	SIDM01033	Bladder Carcinoma	GDSC	PAEKTPVK	DEG_SCF_SKP2-CKS1_1	14:21	Mutation altering degron motif	0.6028
p.A15T	SIDM01609	Endometrial Carcinoma	GDSC	PAEKTPVK	DEG_SCF_SKP2-CKS1_1	14:21	Mutation altering degron motif	0.6028
p.T4S	SIDM00108	Melanoma	GDSC	PAEKTPVK	DEG_SCF_SKP2-CKS1_1	14:21	Mutation blocking phosphorylation signal	0.5
p.A27T	SIDM00789	Colorectal Carcinoma	GDSC	PAEKTPVK	DEG_SCF_SKP2-CKS1_1	14:21	Mutation rewiring degron network	0.1667
p.A8V	SIDM00854	Burkitt's Lymphoma	GDSC	PAEKTPVK	DEG_SCF_SKP2-CKS1_1	14:21	Mutation blocking phosphorylation signal	0.6111
p.I11T	SIDM00309	Mesothelioma	GDSC	PAEKTPVK	DEG_SCF_SKP2-CKS1_1	14:21	Mutation rewiring degron network	0.25
p.A15P	SIDM00165	Other Solid Cancers	GDSC	PAEKTPVK	DEG_SCF_SKP2-CKS1_1	14:21	Mutation altering degron motif	0.6392
p.A8T	SIDM01526	Mesothelioma	GDSC	PAEKTPVK	DEG_SCF_SKP2-CKS1_1	14:21	Mutation blocking phosphorylation signal	0.6111
p.A29T	SIDM01777	Pancreatic Carcinoma	GDSC	PAEKTPVK	DEG_SCF_SKP2-CKS1_1	14:21	Mutation rewiring degron network	0.1111

Kaplan plot for H1-3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

H1-3

UniProt ID: P16402

Entrez ID: 3007

Protein name: Histone H1.3 (Histone H1c) (Histone H1s-2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for H1-3 in