DegronMD

Uniprot ID: P16402

Source protein: Histone H1.3

Source gene: H1-3

Class: DEG_SCF_SKP2-CKS1_1

Location: 14:21

E3 ligase: SKP2,CSK1

DEGRON score: 0.9981

ASA_SCORE: 111.9125

COIL: 0.9551

CONS_SCORE: 0.5098

DSS_SCORE: 0.5914

HELIX: 0.0291

FCONS_SCORE: 1.4323

RIG_SCORE: 0.6937

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A15T	SIDM00588	Oral Cavity Carcinoma	GDSC	PAEKTPVK	DEG_SCF_SKP2-CKS1_1	0.6028
p.A15T	SIDM00437	Acute Myeloid Leukemia	GDSC	PAEKTPVK	DEG_SCF_SKP2-CKS1_1	0.6028
p.A15T	SIDM00577	Neuroblastoma	GDSC	PAEKTPVK	DEG_SCF_SKP2-CKS1_1	0.6028
p.A15T	SIDM01028	Esophageal Squamous Cell Carcinoma	GDSC	PAEKTPVK	DEG_SCF_SKP2-CKS1_1	0.6028
p.A15T	SIDM00573	Glioblastoma	GDSC	PAEKTPVK	DEG_SCF_SKP2-CKS1_1	0.6028
p.A15T	SIDM00687	Gastric Carcinoma	GDSC	PAEKTPVK	DEG_SCF_SKP2-CKS1_1	0.6028
p.A15T	SIDM00250	Esophageal Squamous Cell Carcinoma	GDSC	PAEKTPVK	DEG_SCF_SKP2-CKS1_1	0.6028
p.A15T	SIDM00247	Gastric Carcinoma	GDSC	PAEKTPVK	DEG_SCF_SKP2-CKS1_1	0.6028
p.A15T	SIDM00302	Other Solid Cancers	GDSC	PAEKTPVK	DEG_SCF_SKP2-CKS1_1	0.6028
p.A15T	SIDM01033	Bladder Carcinoma	GDSC	PAEKTPVK	DEG_SCF_SKP2-CKS1_1	0.6028
p.A15T	SIDM01609	Endometrial Carcinoma	GDSC	PAEKTPVK	DEG_SCF_SKP2-CKS1_1	0.6028
p.T4S	SIDM00108	Melanoma	GDSC	PAEKTPVK	DEG_SCF_SKP2-CKS1_1	0.5
p.A27T	SIDM00789	Colorectal Carcinoma	GDSC	PAEKTPVK	DEG_SCF_SKP2-CKS1_1	0.1667
p.A8V	SIDM00854	Burkitt's Lymphoma	GDSC	PAEKTPVK	DEG_SCF_SKP2-CKS1_1	0.6111
p.I11T	SIDM00309	Mesothelioma	GDSC	PAEKTPVK	DEG_SCF_SKP2-CKS1_1	0.25
p.A15P	SIDM00165	Other Solid Cancers	GDSC	PAEKTPVK	DEG_SCF_SKP2-CKS1_1	0.6392
p.A8T	SIDM01526	Mesothelioma	GDSC	PAEKTPVK	DEG_SCF_SKP2-CKS1_1	0.6111
p.A29T	SIDM01777	Pancreatic Carcinoma	GDSC	PAEKTPVK	DEG_SCF_SKP2-CKS1_1	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons