DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
PAEKTPVK
Uniprot ID:
P10412
Source protein:
Histone H1.4
Source gene:
H1-4
Class:
DEG_SCF_SKP2-CKS1_1
Location:
14:21
E3 ligase:
SKP2,CSK1
DEGRON score:
0.9978
ASA_SCORE:
114.6
COIL:
0.9474
CONS_SCORE:
0.4657
DSS_SCORE:
0.6395
HELIX:
0.0373
FCONS_SCORE:
0.9831
RIG_SCORE:
0.6615
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.P19S
SIDM00059
Ovarian Carcinoma
GDSC
PAEKTPVK
DEG_SCF_SKP2-CKS1_1
0.6752
p.P19S
SIDM01750
Melanoma
GDSC
PAEKTPVK
DEG_SCF_SKP2-CKS1_1
0.6752
Drug responses associated with H1-4 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PAEKTPVK
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P10412
Histone H1.4
DEG_SCF_SKP2-CKS1_1
14:21
PAEKTPVK
SKP2,CSK1
0.9978
More...
P16402
Histone H1.3
DEG_SCF_SKP2-CKS1_1
14:21
PAEKTPVK
SKP2,CSK1
0.9981
More...