DegronMD - P16452(EPB42)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P633L	TCGA-EE-A29D	SKCM	TCGA	RGLIHRE	LIG_APCC_ABBAyCdc20_2	628:634	Mutation altering degron motif	0.7582
p.P644S	DO230311	COCA	ICGC	RGLIHRE	LIG_APCC_ABBAyCdc20_2	628:634	Mutation rewiring degron network	0.0556
p.R640H	DO13462	GBM	ICGC	RGLIHRE	LIG_APCC_ABBAyCdc20_2	628:634	Mutation rewiring degron network	0.1667
p.R638K	DO38783	STAD	ICGC	RGLIHRE	LIG_APCC_ABBAyCdc20_2	628:634	Mutation rewiring degron network	0.2222
p.S636N	DO43971	UCEC	ICGC	RGLIHRE	LIG_APCC_ABBAyCdc20_2	628:634	Mutation rewiring degron network	0.2778
p.H619Q	SIDM00933	Breast Carcinoma	GDSC	RGLIHRE	LIG_APCC_ABBAyCdc20_2	628:634	Mutation rewiring degron network	0.0833
p.H619Q	SIDM00855	Other Sarcomas	GDSC	RGLIHRE	LIG_APCC_ABBAyCdc20_2	628:634	Mutation rewiring degron network	0.0833
p.H619Q	SIDM00875	Breast Carcinoma	GDSC	RGLIHRE	LIG_APCC_ABBAyCdc20_2	628:634	Mutation rewiring degron network	0.0833
p.H619Q	SIDM00844	Burkitt's Lymphoma	GDSC	RGLIHRE	LIG_APCC_ABBAyCdc20_2	628:634	Mutation rewiring degron network	0.0833
p.H619Q	SIDM00721	Small Cell Lung Carcinoma	GDSC	RGLIHRE	LIG_APCC_ABBAyCdc20_2	628:634	Mutation rewiring degron network	0.0833
p.H619Q	SIDM01752	Pancreatic Carcinoma	GDSC	RGLIHRE	LIG_APCC_ABBAyCdc20_2	628:634	Mutation rewiring degron network	0.0833
p.A628V	SIDM00643	Non-Cancerous	GDSC	RGLIHRE	LIG_APCC_ABBAyCdc20_2	628:634	Mutation altering degron motif	0.6936
p.E629G	SIDM01049	Non-Cancerous	GDSC	RGLIHRE	LIG_APCC_ABBAyCdc20_2	628:634	Mutation altering degron motif	0.7199
p.E629G	EHEB	haematopoietic and lymphoid tissue	COSMIC	RGLIHRE	LIG_APCC_ABBAyCdc20_2	628:634	Mutation altering degron motif	0.7199
p.M624I	SIDM01780	B-Cell Non-Hodgkin's Lymphoma	GDSC	RGLIHRE	LIG_APCC_ABBAyCdc20_2	628:634	Mutation rewiring degron network	0.2222
p.W643C	ACH-000672	Lung Cancer	CCLE	RGLIHRE	LIG_APCC_ABBAyCdc20_2	628:634	Mutation rewiring degron network	0.0833
p.W643C	IA-LM	lung	COSMIC	RGLIHRE	LIG_APCC_ABBAyCdc20_2	628:634	Mutation rewiring degron network	0.0833
p.M618I	ACH-000761	Gastric Cancer	CCLE	RGLIHRE	LIG_APCC_ABBAyCdc20_2	628:634	Mutation rewiring degron network	0.0556

Kaplan plot for EPB42 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

EPB42

UniProt ID: P16452

Entrez ID: 2038

Protein name: Protein 4.2 (P4.2) (Erythrocyte membrane protein band 4.2) (Erythrocyte protein 4.2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for EPB42 in