DegronMD

Uniprot ID: P16452

Source protein: Protein 4.2

Source gene: EPB42

Class: LIG_APCC_ABBAyCdc20_2

Location: 628:634

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9336

ASA_SCORE: 71.3286

COIL: 0.7353

CONS_SCORE: 0.6989

DSS_SCORE: 0.0929

HELIX: 0.1074

FCONS_SCORE: 1.1917

RIG_SCORE: 0.8071

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P633L	TCGA-EE-A29D	SKCM	TCGA	RGLIHRE	LIG_APCC_ABBAyCdc20_2	0.7582
p.P644S	DO230311	COCA	ICGC	RGLIHRE	LIG_APCC_ABBAyCdc20_2	0.0556
p.R640H	DO13462	GBM	ICGC	RGLIHRE	LIG_APCC_ABBAyCdc20_2	0.1667
p.R638K	DO38783	STAD	ICGC	RGLIHRE	LIG_APCC_ABBAyCdc20_2	0.2222
p.S636N	DO43971	UCEC	ICGC	RGLIHRE	LIG_APCC_ABBAyCdc20_2	0.2778
p.H619Q	SIDM00933	Breast Carcinoma	GDSC	RGLIHRE	LIG_APCC_ABBAyCdc20_2	0.0833
p.H619Q	SIDM00855	Other Sarcomas	GDSC	RGLIHRE	LIG_APCC_ABBAyCdc20_2	0.0833
p.H619Q	SIDM00875	Breast Carcinoma	GDSC	RGLIHRE	LIG_APCC_ABBAyCdc20_2	0.0833
p.H619Q	SIDM00844	Burkitt's Lymphoma	GDSC	RGLIHRE	LIG_APCC_ABBAyCdc20_2	0.0833
p.H619Q	SIDM00721	Small Cell Lung Carcinoma	GDSC	RGLIHRE	LIG_APCC_ABBAyCdc20_2	0.0833
p.H619Q	SIDM01752	Pancreatic Carcinoma	GDSC	RGLIHRE	LIG_APCC_ABBAyCdc20_2	0.0833
p.A628V	SIDM00643	Non-Cancerous	GDSC	RGLIHRE	LIG_APCC_ABBAyCdc20_2	0.6936
p.E629G	SIDM01049	Non-Cancerous	GDSC	RGLIHRE	LIG_APCC_ABBAyCdc20_2	0.7199
p.E629G	EHEB	haematopoietic_and_lymphoid_tissue	COSMIC	RGLIHRE	LIG_APCC_ABBAyCdc20_2	0.7199
p.M624I	SIDM01780	B-Cell Non-Hodgkin's Lymphoma	GDSC	RGLIHRE	LIG_APCC_ABBAyCdc20_2	0.2222
p.W643C	ACH-000672	Lung Cancer	CCLE	RGLIHRE	LIG_APCC_ABBAyCdc20_2	0.0833
p.W643C	IA-LM	lung	COSMIC	RGLIHRE	LIG_APCC_ABBAyCdc20_2	0.0833
p.M618I	ACH-000761	Gastric Cancer	CCLE	RGLIHRE	LIG_APCC_ABBAyCdc20_2	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P16452	Protein 4.2	LIG_APCC_ABBAyCdc20_2	628:634	RGLIHRE	APC,CDC20,FZR1	0.9336	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons