DegronMD - P17020(ZNF16)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.H83Y	TCGA-3N-A9WC	SKCM	TCGA	KEFLHKE	LIG_APCC_ABBAyCdc20_2	74:80	Mutation rewiring degron network	0.25
p.H83Y	DO51234	SKCM	ICGC	KEFLHKE	LIG_APCC_ABBAyCdc20_2	74:80	Mutation rewiring degron network	0.25
p.E84K	TCGA-67-3771	LUAD	TCGA	KEFLHKE	LIG_APCC_ABBAyCdc20_2	74:80	Mutation rewiring degron network	0.2222
p.E84K	TCGA-EE-A2MD	SKCM	TCGA	KEFLHKE	LIG_APCC_ABBAyCdc20_2	74:80	Mutation rewiring degron network	0.2222
p.E84K	DO25797	LUAD	ICGC	KEFLHKE	LIG_APCC_ABBAyCdc20_2	74:80	Mutation rewiring degron network	0.2222
p.E84K	DO222434	MELA	ICGC	KEFLHKE	LIG_APCC_ABBAyCdc20_2	74:80	Mutation rewiring degron network	0.2222
p.E84K	DO37851	SKCM	ICGC	KEFLHKE	LIG_APCC_ABBAyCdc20_2	74:80	Mutation rewiring degron network	0.2222
p.S88P	TCGA-CQ-A4CE	HNSC	TCGA	KEFLHKE	LIG_APCC_ABBAyCdc20_2	74:80	Mutation rewiring degron network	0.1111
p.S88P	DO49071	HNSC	ICGC	KEFLHKE	LIG_APCC_ABBAyCdc20_2	74:80	Mutation rewiring degron network	0.1111
p.E72K	TCGA-EE-A2A2	SKCM	TCGA	KEFLHKE	LIG_APCC_ABBAyCdc20_2	74:80	Mutation rewiring degron network	0.2778
p.E72K	DO37583	SKCM	ICGC	KEFLHKE	LIG_APCC_ABBAyCdc20_2	74:80	Mutation rewiring degron network	0.2778
p.I82M	DO234345	ESAD	ICGC	KEFLHKE	LIG_APCC_ABBAyCdc20_2	74:80	Mutation rewiring degron network	0.2778
p.T71I	DO50936	LICA	ICGC	KEFLHKE	LIG_APCC_ABBAyCdc20_2	74:80	Mutation rewiring degron network	0.25
p.E75A	SIDM00193	Colorectal Carcinoma	GDSC	KEFLHKE	LIG_APCC_ABBAyCdc20_2	74:80	Mutation altering degron motif	0.659
p.E75A	ACH-000991	Colon/Colorectal Cancer	CCLE	KEFLHKE	LIG_APCC_ABBAyCdc20_2	74:80	Mutation altering degron motif	0.659
p.E75A	SNU-81	large intestine	COSMIC	KEFLHKE	LIG_APCC_ABBAyCdc20_2	74:80	Mutation altering degron motif	0.659
p.E87D	SIDM00364	B-Lymphoblastic Leukemia	GDSC	KEFLHKE	LIG_APCC_ABBAyCdc20_2	74:80	Mutation rewiring degron network	0.1389
p.E87D	SIDM00237	Non-Small Cell Lung Carcinoma	GDSC	KEFLHKE	LIG_APCC_ABBAyCdc20_2	74:80	Mutation rewiring degron network	0.1389
p.E87D	SIDM00526	Chronic Myelogenous Leukemia	GDSC	KEFLHKE	LIG_APCC_ABBAyCdc20_2	74:80	Mutation rewiring degron network	0.1389
p.E87D	SIDM01582	Gastric Carcinoma	GDSC	KEFLHKE	LIG_APCC_ABBAyCdc20_2	74:80	Mutation rewiring degron network	0.1389
p.E87D	SIDM01368	Gastric Carcinoma	GDSC	KEFLHKE	LIG_APCC_ABBAyCdc20_2	74:80	Mutation rewiring degron network	0.1389
p.E87D	ACH-000030	Lung Cancer	CCLE	KEFLHKE	LIG_APCC_ABBAyCdc20_2	74:80	Mutation rewiring degron network	0.1389
p.E87D	ACH-000072	Leukemia	CCLE	KEFLHKE	LIG_APCC_ABBAyCdc20_2	74:80	Mutation rewiring degron network	0.1389
p.E87D	ACH-000255	Gastric Cancer	CCLE	KEFLHKE	LIG_APCC_ABBAyCdc20_2	74:80	Mutation rewiring degron network	0.1389
p.E87D	ACH-000507	Gastric Cancer	CCLE	KEFLHKE	LIG_APCC_ABBAyCdc20_2	74:80	Mutation rewiring degron network	0.1389
p.E87D	ACH-000779	Lung Cancer	CCLE	KEFLHKE	LIG_APCC_ABBAyCdc20_2	74:80	Mutation rewiring degron network	0.1389
p.E87D	ACH-002059	Leukemia	CCLE	KEFLHKE	LIG_APCC_ABBAyCdc20_2	74:80	Mutation rewiring degron network	0.1389
p.E87D	PC-14	lung	COSMIC	KEFLHKE	LIG_APCC_ABBAyCdc20_2	74:80	Mutation rewiring degron network	0.1389
p.E87D	P30-OHK	haematopoietic and lymphoid tissue	COSMIC	KEFLHKE	LIG_APCC_ABBAyCdc20_2	74:80	Mutation rewiring degron network	0.1389
p.E87D	MEG-01	haematopoietic and lymphoid tissue	COSMIC	KEFLHKE	LIG_APCC_ABBAyCdc20_2	74:80	Mutation rewiring degron network	0.1389
p.E75Q	SIDM00726	Non-Small Cell Lung Carcinoma	GDSC	KEFLHKE	LIG_APCC_ABBAyCdc20_2	74:80	Mutation altering degron motif	0.5633
p.E75Q	NCI-H2347	lung	COSMIC	KEFLHKE	LIG_APCC_ABBAyCdc20_2	74:80	Mutation altering degron motif	0.5633
p.E72Q	ACH-000328	Brain Cancer	CCLE	KEFLHKE	LIG_APCC_ABBAyCdc20_2	74:80	Mutation rewiring degron network	0.2778

Kaplan plot for ZNF16 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZNF16

UniProt ID: P17020

Entrez ID: 7564

Protein name: Zinc finger protein 16 (Zinc finger protein KOX9)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZNF16 in