DegronMD

Uniprot ID: P17020

Source protein: Zinc finger protein 16

Source gene: ZNF16

Class: LIG_APCC_ABBAyCdc20_2

Location: 74:80

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9252

ASA_SCORE: 115.6857

COIL: 0.6869

CONS_SCORE: 0.4587

DSS_SCORE: 0.5111

HELIX: 0.1587

FCONS_SCORE: 1.0138

RIG_SCORE: 0.7716

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H83Y	TCGA-3N-A9WC	SKCM	TCGA	KEFLHKE	LIG_APCC_ABBAyCdc20_2	0.25
p.H83Y	DO51234	SKCM	ICGC	KEFLHKE	LIG_APCC_ABBAyCdc20_2	0.25
p.E84K	TCGA-67-3771	LUAD	TCGA	KEFLHKE	LIG_APCC_ABBAyCdc20_2	0.2222
p.E84K	TCGA-EE-A2MD	SKCM	TCGA	KEFLHKE	LIG_APCC_ABBAyCdc20_2	0.2222
p.E84K	DO25797	LUAD	ICGC	KEFLHKE	LIG_APCC_ABBAyCdc20_2	0.2222
p.E84K	DO222434	MELA	ICGC	KEFLHKE	LIG_APCC_ABBAyCdc20_2	0.2222
p.E84K	DO37851	SKCM	ICGC	KEFLHKE	LIG_APCC_ABBAyCdc20_2	0.2222
p.S88P	TCGA-CQ-A4CE	HNSC	TCGA	KEFLHKE	LIG_APCC_ABBAyCdc20_2	0.1111
p.S88P	DO49071	HNSC	ICGC	KEFLHKE	LIG_APCC_ABBAyCdc20_2	0.1111
p.E72K	TCGA-EE-A2A2	SKCM	TCGA	KEFLHKE	LIG_APCC_ABBAyCdc20_2	0.2778
p.E72K	DO37583	SKCM	ICGC	KEFLHKE	LIG_APCC_ABBAyCdc20_2	0.2778
p.I82M	DO234345	ESAD	ICGC	KEFLHKE	LIG_APCC_ABBAyCdc20_2	0.2778
p.T71I	DO50936	LICA	ICGC	KEFLHKE	LIG_APCC_ABBAyCdc20_2	0.25
p.E75A	SIDM00193	Colorectal Carcinoma	GDSC	KEFLHKE	LIG_APCC_ABBAyCdc20_2	0.659
p.E75A	ACH-000991	Colon/Colorectal Cancer	CCLE	KEFLHKE	LIG_APCC_ABBAyCdc20_2	0.659
p.E75A	SNU-81	large_intestine	COSMIC	KEFLHKE	LIG_APCC_ABBAyCdc20_2	0.659
p.E87D	SIDM00364	B-Lymphoblastic Leukemia	GDSC	KEFLHKE	LIG_APCC_ABBAyCdc20_2	0.1389
p.E87D	SIDM00237	Non-Small Cell Lung Carcinoma	GDSC	KEFLHKE	LIG_APCC_ABBAyCdc20_2	0.1389
p.E87D	SIDM00526	Chronic Myelogenous Leukemia	GDSC	KEFLHKE	LIG_APCC_ABBAyCdc20_2	0.1389
p.E87D	SIDM01582	Gastric Carcinoma	GDSC	KEFLHKE	LIG_APCC_ABBAyCdc20_2	0.1389
p.E87D	SIDM01368	Gastric Carcinoma	GDSC	KEFLHKE	LIG_APCC_ABBAyCdc20_2	0.1389
p.E87D	ACH-000030	Lung Cancer	CCLE	KEFLHKE	LIG_APCC_ABBAyCdc20_2	0.1389
p.E87D	ACH-000072	Leukemia	CCLE	KEFLHKE	LIG_APCC_ABBAyCdc20_2	0.1389
p.E87D	ACH-000255	Gastric Cancer	CCLE	KEFLHKE	LIG_APCC_ABBAyCdc20_2	0.1389
p.E87D	ACH-000507	Gastric Cancer	CCLE	KEFLHKE	LIG_APCC_ABBAyCdc20_2	0.1389
p.E87D	ACH-000779	Lung Cancer	CCLE	KEFLHKE	LIG_APCC_ABBAyCdc20_2	0.1389
p.E87D	ACH-002059	Leukemia	CCLE	KEFLHKE	LIG_APCC_ABBAyCdc20_2	0.1389
p.E87D	PC-14	lung	COSMIC	KEFLHKE	LIG_APCC_ABBAyCdc20_2	0.1389
p.E87D	P30-OHK	haematopoietic_and_lymphoid_tissue	COSMIC	KEFLHKE	LIG_APCC_ABBAyCdc20_2	0.1389
p.E87D	MEG-01	haematopoietic_and_lymphoid_tissue	COSMIC	KEFLHKE	LIG_APCC_ABBAyCdc20_2	0.1389
p.E75Q	SIDM00726	Non-Small Cell Lung Carcinoma	GDSC	KEFLHKE	LIG_APCC_ABBAyCdc20_2	0.5633
p.E75Q	NCI-H2347	lung	COSMIC	KEFLHKE	LIG_APCC_ABBAyCdc20_2	0.5633
p.E72Q	ACH-000328	Brain Cancer	CCLE	KEFLHKE	LIG_APCC_ABBAyCdc20_2	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: KEFLHKE

Degron related mutations and impact score

Drug responses associated with ZNF16 mutations

All proteins holding degron of KEFLHKE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P17020	Zinc finger protein 16	LIG_APCC_ABBAyCdc20_2	74:80	KEFLHKE	APC,CDC20,FZR1	0.9252	More...