DegronMD

Uniprot ID: P17020

Source protein: Zinc finger protein 16

Source gene: ZNF16

Class: LIG_APCC_ABBAyCdc20_2

Location: 74:80

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9252

ASA_SCORE: 115.6857

COIL: 0.6869

CONS_SCORE: 0.4587

DSS_SCORE: 0.5111

HELIX: 0.1587

FCONS_SCORE: 1.0138

RIG_SCORE: 0.7716

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E75A	SIDM00193	Colorectal Carcinoma	GDSC	KEFLHKE	LIG_APCC_ABBAyCdc20_2	0.659
p.E75A	ACH-000991	Colon/Colorectal Cancer	CCLE	KEFLHKE	LIG_APCC_ABBAyCdc20_2	0.659
p.E75A	SNU-81	large_intestine	COSMIC	KEFLHKE	LIG_APCC_ABBAyCdc20_2	0.659
p.E75Q	SIDM00726	Non-Small Cell Lung Carcinoma	GDSC	KEFLHKE	LIG_APCC_ABBAyCdc20_2	0.5633
p.E75Q	NCI-H2347	lung	COSMIC	KEFLHKE	LIG_APCC_ABBAyCdc20_2	0.5633
p.E72K	TCGA-EE-A2A2	SKCM	TCGA	KEFLHKE	LIG_APCC_ABBAyCdc20_2	0.2778
p.E72K	DO37583	SKCM	ICGC	KEFLHKE	LIG_APCC_ABBAyCdc20_2	0.2778
p.I82M	DO234345	ESAD	ICGC	KEFLHKE	LIG_APCC_ABBAyCdc20_2	0.2778
p.E72Q	ACH-000328	Brain Cancer	CCLE	KEFLHKE	LIG_APCC_ABBAyCdc20_2	0.2778
p.H83Y	TCGA-3N-A9WC	SKCM	TCGA	KEFLHKE	LIG_APCC_ABBAyCdc20_2	0.25
p.H83Y	DO51234	SKCM	ICGC	KEFLHKE	LIG_APCC_ABBAyCdc20_2	0.25
p.T71I	DO50936	LICA	ICGC	KEFLHKE	LIG_APCC_ABBAyCdc20_2	0.25
p.E84K	TCGA-67-3771	LUAD	TCGA	KEFLHKE	LIG_APCC_ABBAyCdc20_2	0.2222
p.E84K	TCGA-EE-A2MD	SKCM	TCGA	KEFLHKE	LIG_APCC_ABBAyCdc20_2	0.2222
p.E84K	DO25797	LUAD	ICGC	KEFLHKE	LIG_APCC_ABBAyCdc20_2	0.2222
p.E84K	DO222434	MELA	ICGC	KEFLHKE	LIG_APCC_ABBAyCdc20_2	0.2222
p.E84K	DO37851	SKCM	ICGC	KEFLHKE	LIG_APCC_ABBAyCdc20_2	0.2222
p.E87D	SIDM00364	B-Lymphoblastic Leukemia	GDSC	KEFLHKE	LIG_APCC_ABBAyCdc20_2	0.1389
p.E87D	SIDM00237	Non-Small Cell Lung Carcinoma	GDSC	KEFLHKE	LIG_APCC_ABBAyCdc20_2	0.1389
p.E87D	SIDM00526	Chronic Myelogenous Leukemia	GDSC	KEFLHKE	LIG_APCC_ABBAyCdc20_2	0.1389
p.E87D	SIDM01582	Gastric Carcinoma	GDSC	KEFLHKE	LIG_APCC_ABBAyCdc20_2	0.1389
p.E87D	SIDM01368	Gastric Carcinoma	GDSC	KEFLHKE	LIG_APCC_ABBAyCdc20_2	0.1389
p.E87D	ACH-000030	Lung Cancer	CCLE	KEFLHKE	LIG_APCC_ABBAyCdc20_2	0.1389
p.E87D	ACH-000072	Leukemia	CCLE	KEFLHKE	LIG_APCC_ABBAyCdc20_2	0.1389
p.E87D	ACH-000255	Gastric Cancer	CCLE	KEFLHKE	LIG_APCC_ABBAyCdc20_2	0.1389

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Drug responses associated with ZNF16 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of KEFLHKE

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P17020	Zinc finger protein 16	LIG_APCC_ABBAyCdc20_2	74:80	KEFLHKE	APC,CDC20,FZR1	0.9252	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: KEFLHKE

Degron related mutations and impact score

Drug responses associated with ZNF16 mutations

All proteins holding degron of KEFLHKE