DegronMD - P17029(ZKSCAN1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A175T	TCGA-AA-3947	COAD	TCGA	FDLHHE	LIG_APCC_ABBA_1	169:174	Mutation rewiring degron network	0.3056
p.S183L	TCGA-AP-A056	UCEC	TCGA	FDLHHE	LIG_APCC_ABBA_1	169:174	Mutation rewiring degron network	0.0833
p.S183L	TCGA-DA-A1IC	SKCM	TCGA	FDLHHE	LIG_APCC_ABBA_1	169:174	Mutation rewiring degron network	0.0833
p.S183L	TCGA-GC-A3YS	BLCA	TCGA	FDLHHE	LIG_APCC_ABBA_1	169:174	Mutation rewiring degron network	0.0833
p.S183L	DO850	BLCA	ICGC	FDLHHE	LIG_APCC_ABBA_1	169:174	Mutation rewiring degron network	0.0833
p.S183L	DO37430	SKCM	ICGC	FDLHHE	LIG_APCC_ABBA_1	169:174	Mutation rewiring degron network	0.0833
p.S183L	DO43971	UCEC	ICGC	FDLHHE	LIG_APCC_ABBA_1	169:174	Mutation rewiring degron network	0.0833
p.H179N	TCGA-BF-A1Q0	SKCM	TCGA	FDLHHE	LIG_APCC_ABBA_1	169:174	Mutation rewiring degron network	0.1944
p.H179N	DO47374	SKCM	ICGC	FDLHHE	LIG_APCC_ABBA_1	169:174	Mutation rewiring degron network	0.1944
p.S184F	TCGA-DA-A1HW	SKCM	TCGA	FDLHHE	LIG_APCC_ABBA_1	169:174	Mutation blocking phosphorylation signal	0.5
p.S184F	DO38129	SKCM	ICGC	FDLHHE	LIG_APCC_ABBA_1	169:174	Mutation blocking phosphorylation signal	0.5
p.H173Y	TCGA-EE-A3J8	SKCM	TCGA	FDLHHE	LIG_APCC_ABBA_1	169:174	Mutation altering degron motif	0.6118
p.H173Y	DO47276	SKCM	ICGC	FDLHHE	LIG_APCC_ABBA_1	169:174	Mutation altering degron motif	0.6118
p.T159M	DO233898	GACA	ICGC	FDLHHE	LIG_APCC_ABBA_1	169:174	Mutation rewiring degron network	0.0556
p.T159M	DO41331	UCEC	ICGC	FDLHHE	LIG_APCC_ABBA_1	169:174	Mutation rewiring degron network	0.0556
p.G160E	DO11429	GBM	ICGC	FDLHHE	LIG_APCC_ABBA_1	169:174	Mutation rewiring degron network	0.0833
p.G170A	DO18412	KIRC	ICGC	FDLHHE	LIG_APCC_ABBA_1	169:174	Mutation altering degron motif	0.754
p.S172I	DO228971	LICA	ICGC	FDLHHE	LIG_APCC_ABBA_1	169:174	Mutation altering degron motif	0.7341
p.P159T	DO50875	LICA	ICGC	FDLHHE	LIG_APCC_ABBA_1	169:174	Mutation rewiring degron network	0.0556
p.R165K	DO25757	LUAD	ICGC	FDLHHE	LIG_APCC_ABBA_1	169:174	Mutation rewiring degron network	0.2222
p.F173L	DO231132	LUSC	ICGC	FDLHHE	LIG_APCC_ABBA_1	169:174	Mutation altering degron motif	0.6981
p.G170C	DO37571	SKCM	ICGC	FDLHHE	LIG_APCC_ABBA_1	169:174	Mutation altering degron motif	0.76
p.H169R	DO43434	UCEC	ICGC	FDLHHE	LIG_APCC_ABBA_1	169:174	Mutation altering degron motif	0.8244
p.R165I	DO41488	UCEC	ICGC	FDLHHE	LIG_APCC_ABBA_1	169:174	Mutation rewiring degron network	0.2222
p.H173N	SIDM00478	Esophageal Squamous Cell Carcinoma	GDSC	FDLHHE	LIG_APCC_ABBA_1	169:174	Mutation altering degron motif	0.6312
p.H173N	ACH-000544	Esophageal Cancer	CCLE	FDLHHE	LIG_APCC_ABBA_1	169:174	Mutation altering degron motif	0.6312
p.H173N	OE21	oesophagus	COSMIC	FDLHHE	LIG_APCC_ABBA_1	169:174	Mutation altering degron motif	0.6312
p.A177V	CTV-1	haematopoietic and lymphoid tissue	COSMIC	FDLHHE	LIG_APCC_ABBA_1	169:174	Mutation rewiring degron network	0.25
p.S180Y	SNU-398	liver	COSMIC	FDLHHE	LIG_APCC_ABBA_1	169:174	Mutation rewiring degron network	0.1667
p.A177T	22RV1	prostate	COSMIC	FDLHHE	LIG_APCC_ABBA_1	169:174	Mutation rewiring degron network	0.25
p.D175E	ChaGo-K-1	lung	COSMIC	FDLHHE	LIG_APCC_ABBA_1	169:174	Mutation rewiring degron network	0.3056
p.T174M	RF-48	stomach	COSMIC	FDLHHE	LIG_APCC_ABBA_1	169:174	Mutation altering degron motif	0.7423

Kaplan plot for ZKSCAN1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZKSCAN1

UniProt ID: P17029

Entrez ID: 7586

Protein name: Zinc finger protein with KRAB and SCAN domains 1 (Zinc finger protein 139) (Zinc finger protein 36) (Zinc finger protein KOX18)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZKSCAN1 in