DegronMD

Uniprot ID: P17029

Source protein: Zinc finger protein with KRAB and SCAN domains 1

Source gene: ZKSCAN1

Class: LIG_APCC_ABBA_1

Location: 169:174

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6811

ASA_SCORE: 97.8333

COIL: 0.48

CONS_SCORE: 0.8111

DSS_SCORE: 0.6221

HELIX: 0.5057

FCONS_SCORE: 0.8452

RIG_SCORE: 0.6625

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A175T	TCGA-AA-3947	COAD	TCGA	FDLHHE	LIG_APCC_ABBA_1	0.3056
p.S183L	TCGA-AP-A056	UCEC	TCGA	FDLHHE	LIG_APCC_ABBA_1	0.0833
p.S183L	TCGA-DA-A1IC	SKCM	TCGA	FDLHHE	LIG_APCC_ABBA_1	0.0833
p.S183L	TCGA-GC-A3YS	BLCA	TCGA	FDLHHE	LIG_APCC_ABBA_1	0.0833
p.S183L	DO850	BLCA	ICGC	FDLHHE	LIG_APCC_ABBA_1	0.0833
p.S183L	DO37430	SKCM	ICGC	FDLHHE	LIG_APCC_ABBA_1	0.0833
p.S183L	DO43971	UCEC	ICGC	FDLHHE	LIG_APCC_ABBA_1	0.0833
p.H179N	TCGA-BF-A1Q0	SKCM	TCGA	FDLHHE	LIG_APCC_ABBA_1	0.1944
p.H179N	DO47374	SKCM	ICGC	FDLHHE	LIG_APCC_ABBA_1	0.1944
p.S184F	TCGA-DA-A1HW	SKCM	TCGA	FDLHHE	LIG_APCC_ABBA_1	0.5
p.S184F	DO38129	SKCM	ICGC	FDLHHE	LIG_APCC_ABBA_1	0.5
p.H173Y	TCGA-EE-A3J8	SKCM	TCGA	FDLHHE	LIG_APCC_ABBA_1	0.6118
p.H173Y	DO47276	SKCM	ICGC	FDLHHE	LIG_APCC_ABBA_1	0.6118
p.T159M	DO233898	GACA	ICGC	FDLHHE	LIG_APCC_ABBA_1	0.0556
p.T159M	DO41331	UCEC	ICGC	FDLHHE	LIG_APCC_ABBA_1	0.0556
p.G160E	DO11429	GBM	ICGC	FDLHHE	LIG_APCC_ABBA_1	0.0833
p.G170A	DO18412	KIRC	ICGC	FDLHHE	LIG_APCC_ABBA_1	0.754
p.S172I	DO228971	LICA	ICGC	FDLHHE	LIG_APCC_ABBA_1	0.7341
p.P159T	DO50875	LICA	ICGC	FDLHHE	LIG_APCC_ABBA_1	0.0556
p.R165K	DO25757	LUAD	ICGC	FDLHHE	LIG_APCC_ABBA_1	0.2222
p.F173L	DO231132	LUSC	ICGC	FDLHHE	LIG_APCC_ABBA_1	0.6981
p.G170C	DO37571	SKCM	ICGC	FDLHHE	LIG_APCC_ABBA_1	0.76
p.H169R	DO43434	UCEC	ICGC	FDLHHE	LIG_APCC_ABBA_1	0.8244
p.R165I	DO41488	UCEC	ICGC	FDLHHE	LIG_APCC_ABBA_1	0.2222
p.H173N	SIDM00478	Esophageal Squamous Cell Carcinoma	GDSC	FDLHHE	LIG_APCC_ABBA_1	0.6312
p.H173N	ACH-000544	Esophageal Cancer	CCLE	FDLHHE	LIG_APCC_ABBA_1	0.6312
p.H173N	OE21	oesophagus	COSMIC	FDLHHE	LIG_APCC_ABBA_1	0.6312
p.A177V	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	FDLHHE	LIG_APCC_ABBA_1	0.25
p.S180Y	SNU-398	liver	COSMIC	FDLHHE	LIG_APCC_ABBA_1	0.1667
p.A177T	22RV1	prostate	COSMIC	FDLHHE	LIG_APCC_ABBA_1	0.25
p.D175E	ChaGo-K-1	lung	COSMIC	FDLHHE	LIG_APCC_ABBA_1	0.3056
p.T174M	RF-48	stomach	COSMIC	FDLHHE	LIG_APCC_ABBA_1	0.7423

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: FDLHHE

Degron related mutations and impact score

Drug responses associated with ZKSCAN1 mutations

All proteins holding degron of FDLHHE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P17029	Zinc finger protein with KRAB and SCAN domains 1	LIG_APCC_ABBA_1	169:174	FDLHHE	APC,CDC20,FZR1	0.6811	More...