DegronMD - P17066(HSPA6)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G465D	TCGA-AA-3947	COAD	TCGA	GRFELSGIP	DEG_APCC_DBOX_1	459:467	Mutation altering degron motif	0.6087
p.G465D	DO8192	COAD	ICGC	GRFELSGIP	DEG_APCC_DBOX_1	459:467	Mutation altering degron motif	0.6087
p.A450V	TCGA-D1-A160	UCEC	TCGA	GRFELSGIP	DEG_APCC_DBOX_1	459:467	Mutation rewiring degron network	0.0833
p.A450V	DO41626	UCEC	ICGC	GRFELSGIP	DEG_APCC_DBOX_1	459:467	Mutation rewiring degron network	0.0833
p.P467S	TCGA-EE-A29V	SKCM	TCGA	GRFELSGIP	DEG_APCC_DBOX_1	459:467	Mutation altering degron motif	0.5641
p.P467S	DO38006	SKCM	ICGC	GRFELSGIP	DEG_APCC_DBOX_1	459:467	Mutation altering degron motif	0.5641
p.P467S	SIDM01662	Plasma Cell Myeloma	GDSC	GRFELSGIP	DEG_APCC_DBOX_1	459:467	Mutation altering degron motif	0.5641
p.R471H	TCGA-LN-A9FR	ESCA	TCGA	GRFELSGIP	DEG_APCC_DBOX_1	459:467	Mutation rewiring degron network	0.2222
p.R471H	DO227976	COCA	ICGC	GRFELSGIP	DEG_APCC_DBOX_1	459:467	Mutation rewiring degron network	0.2222
p.R471H	DO227491	LAML	ICGC	GRFELSGIP	DEG_APCC_DBOX_1	459:467	Mutation rewiring degron network	0.2222
p.Q475H	TCGA-N5-A4RJ	UCS	TCGA	GRFELSGIP	DEG_APCC_DBOX_1	459:467	Mutation rewiring degron network	0.1111
p.S464I	DO229354	LAML	ICGC	GRFELSGIP	DEG_APCC_DBOX_1	459:467	Mutation altering degron motif	0.623
p.S464I	DO227491	LAML	ICGC	GRFELSGIP	DEG_APCC_DBOX_1	459:467	Mutation altering degron motif	0.623
p.S464I	DO224605	LUSC	ICGC	GRFELSGIP	DEG_APCC_DBOX_1	459:467	Mutation altering degron motif	0.623
p.E477K	DO220877	MELA	ICGC	GRFELSGIP	DEG_APCC_DBOX_1	459:467	Mutation rewiring degron network	0.0556
p.P474S	DO222363	MELA	ICGC	GRFELSGIP	DEG_APCC_DBOX_1	459:467	Mutation rewiring degron network	0.1389
p.G459R	SIDM00545	Melanoma	GDSC	GRFELSGIP	DEG_APCC_DBOX_1	459:467	Mutation altering degron motif	0.6457
p.G459R	Mewo	skin	COSMIC	GRFELSGIP	DEG_APCC_DBOX_1	459:467	Mutation altering degron motif	0.6457

Kaplan plot for HSPA6 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

HSPA6

UniProt ID: P17066

Entrez ID: 3310

Protein name: Heat shock 70 kDa protein 6 (Heat shock 70 kDa protein B')

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for HSPA6 in