DegronMD

Uniprot ID: P17066

Source protein: Heat shock 70 kDa protein 6

Source gene: HSPA6

Class: DEG_APCC_DBOX_1

Location: 459:467

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8607

ASA_SCORE: 50.6889

COIL: 0.5469

CONS_SCORE: 0.882

DSS_SCORE: 0.3862

HELIX: 0.053

FCONS_SCORE: 0.9886

RIG_SCORE: 0.7639

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G465D	TCGA-AA-3947	COAD	TCGA	GRFELSGIP	DEG_APCC_DBOX_1	0.6087
p.G465D	DO8192	COAD	ICGC	GRFELSGIP	DEG_APCC_DBOX_1	0.6087
p.A450V	TCGA-D1-A160	UCEC	TCGA	GRFELSGIP	DEG_APCC_DBOX_1	0.0833
p.A450V	DO41626	UCEC	ICGC	GRFELSGIP	DEG_APCC_DBOX_1	0.0833
p.P467S	TCGA-EE-A29V	SKCM	TCGA	GRFELSGIP	DEG_APCC_DBOX_1	0.5641
p.P467S	DO38006	SKCM	ICGC	GRFELSGIP	DEG_APCC_DBOX_1	0.5641
p.P467S	SIDM01662	Plasma Cell Myeloma	GDSC	GRFELSGIP	DEG_APCC_DBOX_1	0.5641
p.R471H	TCGA-LN-A9FR	ESCA	TCGA	GRFELSGIP	DEG_APCC_DBOX_1	0.2222
p.R471H	DO227976	COCA	ICGC	GRFELSGIP	DEG_APCC_DBOX_1	0.2222
p.R471H	DO227491	LAML	ICGC	GRFELSGIP	DEG_APCC_DBOX_1	0.2222
p.Q475H	TCGA-N5-A4RJ	UCS	TCGA	GRFELSGIP	DEG_APCC_DBOX_1	0.1111
p.S464I	DO229354	LAML	ICGC	GRFELSGIP	DEG_APCC_DBOX_1	0.623
p.S464I	DO227491	LAML	ICGC	GRFELSGIP	DEG_APCC_DBOX_1	0.623
p.S464I	DO224605	LUSC	ICGC	GRFELSGIP	DEG_APCC_DBOX_1	0.623
p.E477K	DO220877	MELA	ICGC	GRFELSGIP	DEG_APCC_DBOX_1	0.0556
p.P474S	DO222363	MELA	ICGC	GRFELSGIP	DEG_APCC_DBOX_1	0.1389
p.G459R	SIDM00545	Melanoma	GDSC	GRFELSGIP	DEG_APCC_DBOX_1	0.6457
p.G459R	Mewo	skin	COSMIC	GRFELSGIP	DEG_APCC_DBOX_1	0.6457

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P17066	Heat shock 70 kDa protein 6	DEG_APCC_DBOX_1	459:467	GRFELSGIP	APC,CDC20,FZR1	0.8607	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons