IFNAR1
UniProt ID: P17181
Entrez ID: 3454
Protein name: Interferon alpha/beta receptor 1 (IFN-R-1) (IFN-alpha/beta receptor 1) (Cytokine receptor class-II member 1) (Cytokine receptor family 2 member 1) (CRF2-1) (Type I interferon receptor 1)
External links: UniprotKB HGNC RefSeq COSMIC
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FUNCTION: Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1 (PubMed:2153461, PubMed:7665574, PubMed:10049744, PubMed:14532120, PubMed:15337770, PubMed:21854986). Functions in general as heterodimer with IFNAR2 (PubMed:7665574, PubMed:10049744, PubMed:2185...
FUNCTION: Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1 (PubMed:2153461, PubMed:7665574, PubMed:10049744, PubMed:14532120, PubMed:15337770, PubMed:21854986). Functions in general as heterodimer with IFNAR2 (PubMed:7665574, PubMed:10049744, PubMed:21854986). Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta-subunits themselves (PubMed:7665574, PubMed:21854986, PubMed:32972995). Can form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway (By similarity). {ECO:0000250|UniProtKB:P33896, ECO:0000269|PubMed:10049744, ECO:0000269|PubMed:14532120, ECO:0000269|PubMed:15337770, ECO:0000269|PubMed:19561067, ECO:0000269|PubMed:2153461, ECO:0000269|PubMed:32972995, ECO:0000269|PubMed:7665574, ECO:0000305|PubMed:21854986}.
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GO - Biological processes (BP):
cellular response to interferon-alpha [GO:0035457]; cellular response to virus [GO:0098586]; cytokine-mediated signaling pathway [GO:0019221]; positive regulation of cellular respiration [GO:1901857]; receptor signaling pathway via JAK-STAT [GO:0007259]; response to lipopolysaccharide [GO:0032496]; ...
cellular response to interferon-alpha [GO:0035457]; cellular response to virus [GO:0098586]; cytokine-mediated signaling pathway [GO:0019221]; positive regulation of cellular respiration [GO:1901857]; receptor signaling pathway via JAK-STAT [GO:0007259]; response to lipopolysaccharide [GO:0032496]; response to virus [GO:0009615]; type I interferon signaling pathway [GO:0060337]
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GO - Molecular function (MF):
cytokine receptor activity [GO:0004896]; type I interferon binding [GO:0019962]; type I interferon receptor activity [GO:0004905]...
cytokine receptor activity [GO:0004896]; type I interferon binding [GO:0019962]; type I interferon receptor activity [GO:0004905]
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GO - Cellular component (CC):
integral component of plasma membrane [GO:0005887]; late endosome [GO:0005770]; lysosome [GO:0005764]; plasma membrane [GO:0005886]...
integral component of plasma membrane [GO:0005887]; late endosome [GO:0005770]; lysosome [GO:0005764]; plasma membrane [GO:0005886]
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IFNAR1
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Kaplan plot for IFNAR1 in
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*NOTE: the Kaplan plots were collected from OncoLnc