DegronMD

Uniprot ID: P17181

Source protein: Interferon alpha/beta receptor 1

Source gene: IFNAR1

Class: DEG_SCF_TRCP1_1

Location: 534:539

E3 ligase: BTRC

DEGRON score: 0.9985

ASA_SCORE: 75.1

COIL: 0.7825

CONS_SCORE: 0.6366

DSS_SCORE: 0.7133

HELIX: 0.0465

FCONS_SCORE: 1.3731

RIG_SCORE: 0.5499

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S529F	TCGA-AA-A010	COAD	TCGA	DSGNYS	DEG_SCF_TRCP1_1	0.1944
p.D542N	TCGA-C5-A1ML	CESC	TCGA	DSGNYS	DEG_SCF_TRCP1_1	0.25
p.K547T	TCGA-IB-7651	PAAD	TCGA	DSGNYS	DEG_SCF_TRCP1_1	0.2222
p.S546I	TCGA-L9-A7SV	LUAD	TCGA	DSGNYS	DEG_SCF_TRCP1_1	0.1389
p.E541K	ACH-001853	Bile Duct Cancer	CCLE	DSGNYS	DEG_SCF_TRCP1_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P08887	Interleukin-6 receptor subunit alpha	DEG_SCF_TRCP1_1	90:95	DSGNYS	BTRC	0.6944	More...
P17181	Interferon alpha/beta receptor 1	DEG_SCF_TRCP1_1	534:539	DSGNYS	BTRC	0.9985	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons