DegronMD

Uniprot ID: P08887

Source protein: Interleukin-6 receptor subunit alpha

Source gene: IL6R

Class: DEG_SCF_TRCP1_1

Location: 90:95

E3 ligase: BTRC

DEGRON score: 0.6944

ASA_SCORE: 44.7

COIL: 0.36

CONS_SCORE: 0.7271

DSS_SCORE: 0.2622

HELIX: 0.0437

FCONS_SCORE: 1.2573

RIG_SCORE: 0.705

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T105S	TCGA-50-5932	LUAD	TCGA	DSGNYS	DEG_SCF_TRCP1_1	0.0556
p.T105S	DO23610	LUAD	ICGC	DSGNYS	DEG_SCF_TRCP1_1	0.0556
p.R80G	TCGA-BS-A0UF	UCEC	TCGA	DSGNYS	DEG_SCF_TRCP1_1	0.0556
p.R80G	DO41488	UCEC	ICGC	DSGNYS	DEG_SCF_TRCP1_1	0.0556
p.R101H	SIDM00333	Endometrial Carcinoma	GDSC	DSGNYS	DEG_SCF_TRCP1_1	0.1667
p.R101H	ACH-000988	Endometrial/Uterine Cancer	CCLE	DSGNYS	DEG_SCF_TRCP1_1	0.1667
p.R101H	MFE-319	endometrium	COSMIC	DSGNYS	DEG_SCF_TRCP1_1	0.1667
p.Y94H	SIDM00878	Breast Carcinoma	GDSC	DSGNYS	DEG_SCF_TRCP1_1	0.6118
p.Y94H	ACH-000930	Breast Cancer	CCLE	DSGNYS	DEG_SCF_TRCP1_1	0.6118

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P08887	Interleukin-6 receptor subunit alpha	DEG_SCF_TRCP1_1	90:95	DSGNYS	BTRC	0.6944	More...
P17181	Interferon alpha/beta receptor 1	DEG_SCF_TRCP1_1	534:539	DSGNYS	BTRC	0.9985	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons