DegronMD - P17483(HOXB4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P119Q	TCGA-05-4249	LUAD	TCGA	AVSSS	DEG_SPOP_SBC_1	112:116	Mutation rewiring degron network	0.25
p.P119Q	DO23891	LUAD	ICGC	AVSSS	DEG_SPOP_SBC_1	112:116	Mutation rewiring degron network	0.25
p.Q124H	TCGA-EE-A3AA	SKCM	TCGA	AVSSS	DEG_SPOP_SBC_1	112:116	Mutation rewiring degron network	0.1111
p.Q124H	DO37571	SKCM	ICGC	AVSSS	DEG_SPOP_SBC_1	112:116	Mutation rewiring degron network	0.1111
p.P117H	TCGA-ER-A19H	SKCM	TCGA	AVSSS	DEG_SPOP_SBC_1	112:116	Mutation rewiring degron network	0.3056
p.P117H	DO47299	SKCM	ICGC	AVSSS	DEG_SPOP_SBC_1	112:116	Mutation rewiring degron network	0.3056
p.P118L	TCGA-VQ-A8PO	STAD	TCGA	AVSSS	DEG_SPOP_SBC_1	112:116	Mutation rewiring degron network	0.2778
p.P118L	DO51773	STAD	ICGC	AVSSS	DEG_SPOP_SBC_1	112:116	Mutation rewiring degron network	0.2778
p.P118L	SIDM00658	Non-Small Cell Lung Carcinoma	GDSC	AVSSS	DEG_SPOP_SBC_1	112:116	Mutation rewiring degron network	0.2778
p.P118L	ACH-000852	Lung Cancer	CCLE	AVSSS	DEG_SPOP_SBC_1	112:116	Mutation rewiring degron network	0.2778
p.P118L	NCI-H1435	lung	COSMIC	AVSSS	DEG_SPOP_SBC_1	112:116	Mutation rewiring degron network	0.2778
p.V113A	DO22929	LIHC	ICGC	AVSSS	DEG_SPOP_SBC_1	112:116	Mutation altering degron motif	0.5825
p.C122G	DO229253	THCA	ICGC	AVSSS	DEG_SPOP_SBC_1	112:116	Mutation rewiring degron network	0.1667
p.E105D	DO229257	THCA	ICGC	AVSSS	DEG_SPOP_SBC_1	112:116	Mutation rewiring degron network	0.1389
p.C122R	DO229201	THCA	ICGC	AVSSS	DEG_SPOP_SBC_1	112:116	Mutation rewiring degron network	0.1667
p.C110S	SIDM00845	Burkitt's Lymphoma	GDSC	AVSSS	DEG_SPOP_SBC_1	112:116	Mutation rewiring degron network	0.2778
p.C110S	SIDM01519	Head and Neck Carcinoma	GDSC	AVSSS	DEG_SPOP_SBC_1	112:116	Mutation rewiring degron network	0.2778
p.C110S	Daudi	haematopoietic and lymphoid tissue	COSMIC	AVSSS	DEG_SPOP_SBC_1	112:116	Mutation rewiring degron network	0.2778

Kaplan plot for HOXB4 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

HOXB4

UniProt ID: P17483

Entrez ID: 3214

Protein name: Homeobox protein Hox-B4 (Homeobox protein Hox-2.6) (Homeobox protein Hox-2F)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for HOXB4 in