DegronMD

Uniprot ID: P17483

Source protein: Homeobox protein Hox-B4

Source gene: HOXB4

Class: DEG_SPOP_SBC_1

Location: 112:116

E3 ligase: SPOP

DEGRON score: 0.9569

ASA_SCORE: 89.98

COIL: 0.9324

CONS_SCORE: 0.6047

DSS_SCORE: 0.6292

HELIX: 0.0658

FCONS_SCORE: 1.3683

RIG_SCORE: 0.5389

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V113A	DO22929	LIHC	ICGC	AVSSS	DEG_SPOP_SBC_1	0.5825
p.P117H	TCGA-ER-A19H	SKCM	TCGA	AVSSS	DEG_SPOP_SBC_1	0.3056
p.P117H	DO47299	SKCM	ICGC	AVSSS	DEG_SPOP_SBC_1	0.3056
p.P118L	TCGA-VQ-A8PO	STAD	TCGA	AVSSS	DEG_SPOP_SBC_1	0.2778
p.P118L	DO51773	STAD	ICGC	AVSSS	DEG_SPOP_SBC_1	0.2778
p.P118L	SIDM00658	Non-Small Cell Lung Carcinoma	GDSC	AVSSS	DEG_SPOP_SBC_1	0.2778
p.P118L	ACH-000852	Lung Cancer	CCLE	AVSSS	DEG_SPOP_SBC_1	0.2778
p.P118L	NCI-H1435	lung	COSMIC	AVSSS	DEG_SPOP_SBC_1	0.2778
p.C110S	SIDM00845	Burkitt's Lymphoma	GDSC	AVSSS	DEG_SPOP_SBC_1	0.2778
p.C110S	SIDM01519	Head and Neck Carcinoma	GDSC	AVSSS	DEG_SPOP_SBC_1	0.2778
p.C110S	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	AVSSS	DEG_SPOP_SBC_1	0.2778
p.P119Q	TCGA-05-4249	LUAD	TCGA	AVSSS	DEG_SPOP_SBC_1	0.25
p.P119Q	DO23891	LUAD	ICGC	AVSSS	DEG_SPOP_SBC_1	0.25
p.C122G	DO229253	THCA	ICGC	AVSSS	DEG_SPOP_SBC_1	0.1667
p.C122R	DO229201	THCA	ICGC	AVSSS	DEG_SPOP_SBC_1	0.1667
p.E105D	DO229257	THCA	ICGC	AVSSS	DEG_SPOP_SBC_1	0.1389
p.Q124H	TCGA-EE-A3AA	SKCM	TCGA	AVSSS	DEG_SPOP_SBC_1	0.1111
p.Q124H	DO37571	SKCM	ICGC	AVSSS	DEG_SPOP_SBC_1	0.1111

Showing 1 to 18 of 18 entries

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Drug responses associated with HOXB4 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of AVSSS

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q0VDD7	Break repair meiotic recombinase recruitment factor 1	DEG_SPOP_SBC_1	66:70	AVSSS	SPOP	0.9837	More...
Q9HCK8	Chromodomain-helicase-DNA-binding protein 8	DEG_SPOP_SBC_1	142:146	AVSSS	SPOP	0.9881	More...
Q8IZA0	Dyslexia-associated protein KIAA0319-like protein	DEG_SPOP_SBC_1	173:177	AVSSS	SPOP	0.8972	More...
P17483	Homeobox protein Hox-B4	DEG_SPOP_SBC_1	112:116	AVSSS	SPOP	0.9569	More...
P32242	Homeobox protein OTX1	DEG_SPOP_SBC_1	131:135	AVSSS	SPOP	0.9911	More...
Q9Y4X4	Krueppel-like factor 12	DEG_SPOP_SBC_1	95:99	AVSSS	SPOP	0.9994	More...
P43358	Melanoma-associated antigen 4	DEG_SPOP_SBC_1	39:43	AVSSS	SPOP	0.8472	More...
Q96JE9	Microtubule-associated protein 6	DEG_SPOP_SBC_1	296:300	AVSSS	SPOP	0.8997	More...
P54278	Mismatch repair endonuclease PMS2	DEG_SPOP_SBC_1	474:478	AVSSS	SPOP	0.999	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1491:1495	AVSSS	SPOP	0.9129	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1844:1848	AVSSS	SPOP	0.8391	More...
Q9ULH7	Myocardin-related transcription factor B	DEG_SPOP_SBC_1	437:441	AVSSS	SPOP	0.6865	More...
Q13613	Myotubularin-related protein 1	DEG_SPOP_SBC_1	643:647	AVSSS	SPOP	0.8381	More...
Q8NEY8	Periphilin-1	DEG_SPOP_SBC_1	211:215	AVSSS	SPOP	0.9988	More...
Q96PX9	Pleckstrin homology domain-containing family G member 4B	DEG_SPOP_SBC_1	1174:1178	AVSSS	SPOP	0.7969	More...
Q92562	Polyphosphoinositide phosphatase	DEG_SPOP_SBC_1	753:757	AVSSS	SPOP	0.9974	More...
P84996	Protein ALEX	DEG_SPOP_SBC_1	603:607	AVSSS	SPOP	0.9965	More...
Q9UPA5	Protein bassoon	DEG_SPOP_SBC_1	3392:3396	AVSSS	SPOP	0.8731	More...
Q06455	Protein CBFA2T1	DEG_SPOP_SBC_1	565:569	AVSSS	SPOP	0.9927	More...
P34910	Protein EVI2B	DEG_SPOP_SBC_1	329:333	AVSSS	SPOP	0.9223	More...
Q5U5X8	Protein FAM222A	DEG_SPOP_SBC_1	109:113	AVSSS	SPOP	0.9845	More...
Q68D20	Protein PMS2CL	DEG_SPOP_SBC_1	88:92	AVSSS	SPOP	0.7454	More...
P43359	Putative melanoma-associated antigen 5P	DEG_SPOP_SBC_1	38:42	AVSSS	SPOP	0.8963	More...
Q9NSC2	Sal-like protein 1	DEG_SPOP_SBC_1	369:373	AVSSS	SPOP	0.7672	More...
Q9H2S1	Small conductance calcium-activated potassium channel protein 2	DEG_SPOP_SBC_1	58:62	AVSSS	SPOP	0.5155	More...

Showing 1 to 25 of 35 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: AVSSS

Degron related mutations and impact score

Drug responses associated with HOXB4 mutations

All proteins holding degron of AVSSS