DegronMD - Q96PX9(PLEKHG4B)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.I732M	TCGA-06-5416	GBM	TCGA	DSGPRDS	DEG_SCF_TRCP1_1	736:742	Mutation rewiring degron network	0.2222
p.I732M	DO10880	GBM	ICGC	DSGPRDS	DEG_SCF_TRCP1_1	736:742	Mutation rewiring degron network	0.2222
p.H1180L	TCGA-37-4135	LUSC	TCGA	AVSSS	DEG_SPOP_SBC_1	1174:1178	Mutation rewiring degron network	0.2778
p.H1180L	DO26806	LUSC	ICGC	AVSSS	DEG_SPOP_SBC_1	1174:1178	Mutation rewiring degron network	0.2778
p.S1178F	TCGA-73-4658	LUAD	TCGA	AVSSS	DEG_SPOP_SBC_1	1174:1178	Mutation altering degron motif	0.7982
p.S1178F	DO23663	LUAD	ICGC	AVSSS	DEG_SPOP_SBC_1	1174:1178	Mutation altering degron motif	0.7982
p.P1183T	TCGA-75-5146	LUAD	TCGA	AVSSS	DEG_SPOP_SBC_1	1174:1178	Mutation rewiring degron network	0.1944
p.P1183T	DO25228	LUAD	ICGC	AVSSS	DEG_SPOP_SBC_1	1174:1178	Mutation rewiring degron network	0.1944
p.S749N	TCGA-78-7536	LUAD	TCGA	DSGPRDS	DEG_SCF_TRCP1_1	736:742	Mutation rewiring degron network	0.1389
p.S749N	DO26414	LUAD	ICGC	DSGPRDS	DEG_SCF_TRCP1_1	736:742	Mutation rewiring degron network	0.1389
p.E731K	TCGA-78-7633	LUAD	TCGA	DSGPRDS	DEG_SCF_TRCP1_1	736:742	Mutation rewiring degron network	0.1944
p.E731K	DO24359	LUAD	ICGC	DSGPRDS	DEG_SCF_TRCP1_1	736:742	Mutation rewiring degron network	0.1944
p.K1185M	TCGA-85-A4QR	LUSC	TCGA	AVSSS	DEG_SPOP_SBC_1	1174:1178	Mutation substituting flanking lysine	0.25
p.K1185M	DO45523	LUSC	ICGC	AVSSS	DEG_SPOP_SBC_1	1174:1178	Mutation substituting flanking lysine	0.25
p.D736N	TCGA-AA-3510	COAD	TCGA	DSGPRDS	DEG_SCF_TRCP1_1	736:742	Mutation altering degron motif	0.6932
p.D736N	DO7783	COAD	ICGC	DSGPRDS	DEG_SCF_TRCP1_1	736:742	Mutation altering degron motif	0.6932
p.T727M	TCGA-AP-A0LM	UCEC	TCGA	DSGPRDS	DEG_SCF_TRCP1_1	736:742	Mutation rewiring degron network	0.0833
p.T727M	TCGA-EO-A22U	UCEC	TCGA	DSGPRDS	DEG_SCF_TRCP1_1	736:742	Mutation rewiring degron network	0.0833
p.T727M	DO43306	UCEC	ICGC	DSGPRDS	DEG_SCF_TRCP1_1	736:742	Mutation rewiring degron network	0.0833
p.T727M	DO43755	UCEC	ICGC	DSGPRDS	DEG_SCF_TRCP1_1	736:742	Mutation rewiring degron network	0.0833
p.A1182T	TCGA-AX-A1CE	UCEC	TCGA	AVSSS	DEG_SPOP_SBC_1	1174:1178	Mutation rewiring degron network	0.2222
p.A1182T	TCGA-B5-A11E	UCEC	TCGA	AVSSS	DEG_SPOP_SBC_1	1174:1178	Mutation rewiring degron network	0.2222
p.A1182T	DO42280	UCEC	ICGC	AVSSS	DEG_SPOP_SBC_1	1174:1178	Mutation rewiring degron network	0.2222
p.A1182T	DO41644	UCEC	ICGC	AVSSS	DEG_SPOP_SBC_1	1174:1178	Mutation rewiring degron network	0.2222
p.A1182T	ACH-000966	Ovarian Cancer	CCLE	AVSSS	DEG_SPOP_SBC_1	1174:1178	Mutation rewiring degron network	0.2222
p.A1182T	ACH-000989	Colon/Colorectal Cancer	CCLE	AVSSS	DEG_SPOP_SBC_1	1174:1178	Mutation rewiring degron network	0.2222
p.A1182T	SNU-175	large intestine	COSMIC	AVSSS	DEG_SPOP_SBC_1	1174:1178	Mutation rewiring degron network	0.2222
p.E59K	TCGA-D8-A73U	BRCA	TCGA	PQQTPSLE	DEG_SCF_FBW7_2	52:59	Mutation altering degron motif	0.7022
p.E59K	DO219629	BRCA	ICGC	PQQTPSLE	DEG_SCF_FBW7_2	52:59	Mutation altering degron motif	0.7022
p.R62S	TCGA-EO-A22U	UCEC	TCGA	PQQTPSLE	DEG_SCF_FBW7_2	52:59	Mutation rewiring degron network	0.25
p.R62S	DO43755	UCEC	ICGC	PQQTPSLE	DEG_SCF_FBW7_2	52:59	Mutation rewiring degron network	0.25
p.K60N	TCGA-IB-7651	PAAD	TCGA	PQQTPSLE	DEG_SCF_FBW7_2	52:59	Mutation rewiring degron network	0.3056
p.K60N	DO46657	PAAD	ICGC	PQQTPSLE	DEG_SCF_FBW7_2	52:59	Mutation rewiring degron network	0.3056
p.M1169I	TCGA-IH-A3EA	SKCM	TCGA	AVSSS	DEG_SPOP_SBC_1	1174:1178	Mutation rewiring degron network	0.1944
p.M1169I	DO37667	SKCM	ICGC	AVSSS	DEG_SPOP_SBC_1	1174:1178	Mutation rewiring degron network	0.1944
p.Q54H	DO230313	COCA	ICGC	PQQTPSLE	DEG_SCF_FBW7_2	52:59	Mutation altering degron motif	0.647
p.P745S	DO222794	COCA	ICGC	DSGPRDS	DEG_SCF_TRCP1_1	736:742	Mutation rewiring degron network	0.25
p.F730L	DO233098	GACA	ICGC	DSGPRDS	DEG_SCF_TRCP1_1	736:742	Mutation rewiring degron network	0.1667
p.G69D	DO228945	LICA	ICGC	PQQTPSLE	DEG_SCF_FBW7_2	52:59	Mutation rewiring degron network	0.0556
p.A1181S	DO229029	LICA	ICGC	AVSSS	DEG_SPOP_SBC_1	1174:1178	Mutation rewiring degron network	0.25
p.S66N	DO229054	LICA	ICGC	PQQTPSLE	DEG_SCF_FBW7_2	52:59	Mutation rewiring degron network	0.1389
p.R49Q	DO222753	MELA	ICGC	PQQTPSLE	DEG_SCF_FBW7_2	52:59	Mutation rewiring degron network	0.25
p.Q744R	SIDM00690	Head and Neck Carcinoma	GDSC	DSGPRDS	DEG_SCF_TRCP1_1	736:742	Mutation rewiring degron network	0.2778
p.Q744R	SIDM01318	Hepatocellular Carcinoma	GDSC	DSGPRDS	DEG_SCF_TRCP1_1	736:742	Mutation rewiring degron network	0.2778
p.Q744R	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	DSGPRDS	DEG_SCF_TRCP1_1	736:742	Mutation rewiring degron network	0.2778
p.E740K	SIDM00498	Colorectal Carcinoma	GDSC	DSGPRDS	DEG_SCF_TRCP1_1	736:742	Mutation altering degron motif	0.7022
p.E740K	SNU-C5	large intestine	COSMIC	DSGPRDS	DEG_SCF_TRCP1_1	736:742	Mutation altering degron motif	0.7022
p.A1171T	SIDM00217	Colorectal Carcinoma	GDSC	AVSSS	DEG_SPOP_SBC_1	1174:1178	Mutation rewiring degron network	0.25
p.A1171T	SNU-1040	large intestine	COSMIC	AVSSS	DEG_SPOP_SBC_1	1174:1178	Mutation rewiring degron network	0.25
p.M748T	SIDM00132	Pancreatic Carcinoma	GDSC	DSGPRDS	DEG_SCF_TRCP1_1	736:742	Mutation rewiring degron network	0.1667
p.M748T	BxPC-3	pancreas	COSMIC	DSGPRDS	DEG_SCF_TRCP1_1	736:742	Mutation rewiring degron network	0.1667
p.R1178W	SIDM01766	Chondrosarcoma	GDSC	AVSSS	DEG_SPOP_SBC_1	1174:1178	Mutation altering degron motif	0.8634
p.S1178C	ACH-000860	Lung Cancer	CCLE	AVSSS	DEG_SPOP_SBC_1	1174:1178	Mutation altering degron motif	0.7541
p.S1178C	NCI-H358	lung	COSMIC	AVSSS	DEG_SPOP_SBC_1	1174:1178	Mutation altering degron motif	0.7541
p.R740M	ACH-000977	lymph node	CCLE	DSGPRDS	DEG_SCF_TRCP1_1	736:742	Mutation altering degron motif	0.7521
p.R740M	LNCaP-Clone-FGC	prostate	COSMIC	DSGPRDS	DEG_SCF_TRCP1_1	736:742	Mutation altering degron motif	0.7521
p.R1170S	EVSA-T	breast	COSMIC	AVSSS	DEG_SPOP_SBC_1	1174:1178	Mutation rewiring degron network	0.2222
p.A1181V	DU-145	prostate	COSMIC	AVSSS	DEG_SPOP_SBC_1	1174:1178	Mutation rewiring degron network	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PLEKHG4B

UniProt ID: Q96PX9

Entrez ID: 153478

Protein name: Pleckstrin homology domain-containing family G member 4B (PH domain-containing family G member 4B)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PLEKHG4B in