DegronMD

Uniprot ID: Q96PX9

Source protein: Pleckstrin homology domain-containing family G member 4B

Source gene: PLEKHG4B

Class: DEG_SCF_FBW7_2

Location: 52:59

E3 ligase: FBXW7

DEGRON score: 0.8121

ASA_SCORE: 92.1125

COIL: 0.8173

CONS_SCORE: 0.3539

DSS_SCORE: 0.9096

HELIX: 0.1538

FCONS_SCORE: 0.9846

RIG_SCORE: 0.5764

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E59K	TCGA-D8-A73U	BRCA	TCGA	PQQTPSLE	DEG_SCF_FBW7_2	0.7022
p.E59K	DO219629	BRCA	ICGC	PQQTPSLE	DEG_SCF_FBW7_2	0.7022
p.R62S	TCGA-EO-A22U	UCEC	TCGA	PQQTPSLE	DEG_SCF_FBW7_2	0.25
p.R62S	DO43755	UCEC	ICGC	PQQTPSLE	DEG_SCF_FBW7_2	0.25
p.K60N	TCGA-IB-7651	PAAD	TCGA	PQQTPSLE	DEG_SCF_FBW7_2	0.3056
p.K60N	DO46657	PAAD	ICGC	PQQTPSLE	DEG_SCF_FBW7_2	0.3056
p.Q54H	DO230313	COCA	ICGC	PQQTPSLE	DEG_SCF_FBW7_2	0.647
p.G69D	DO228945	LICA	ICGC	PQQTPSLE	DEG_SCF_FBW7_2	0.0556
p.S66N	DO229054	LICA	ICGC	PQQTPSLE	DEG_SCF_FBW7_2	0.1389
p.R49Q	DO222753	MELA	ICGC	PQQTPSLE	DEG_SCF_FBW7_2	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96PX9	Pleckstrin homology domain-containing family G member 4B	DEG_SCF_FBW7_2	52:59	PQQTPSLE	FBXW7	0.8121	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons