DegronMD

Uniprot ID: Q96PX9

Source protein: Pleckstrin homology domain-containing family G member 4B

Source gene: PLEKHG4B

Class: DEG_SCF_TRCP1_1

Location: 736:742

E3 ligase: BTRC

DEGRON score: 0.7262

ASA_SCORE: 81.5143

COIL: 0.8754

CONS_SCORE: 0.342

DSS_SCORE: 0.7268

HELIX: 0.0837

FCONS_SCORE: 0.8921

RIG_SCORE: 0.5651

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I732M	TCGA-06-5416	GBM	TCGA	DSGPRDS	DEG_SCF_TRCP1_1	0.2222
p.I732M	DO10880	GBM	ICGC	DSGPRDS	DEG_SCF_TRCP1_1	0.2222
p.S749N	TCGA-78-7536	LUAD	TCGA	DSGPRDS	DEG_SCF_TRCP1_1	0.1389
p.S749N	DO26414	LUAD	ICGC	DSGPRDS	DEG_SCF_TRCP1_1	0.1389
p.E731K	TCGA-78-7633	LUAD	TCGA	DSGPRDS	DEG_SCF_TRCP1_1	0.1944
p.E731K	DO24359	LUAD	ICGC	DSGPRDS	DEG_SCF_TRCP1_1	0.1944
p.D736N	TCGA-AA-3510	COAD	TCGA	DSGPRDS	DEG_SCF_TRCP1_1	0.6932
p.D736N	DO7783	COAD	ICGC	DSGPRDS	DEG_SCF_TRCP1_1	0.6932
p.T727M	TCGA-AP-A0LM	UCEC	TCGA	DSGPRDS	DEG_SCF_TRCP1_1	0.0833
p.T727M	TCGA-EO-A22U	UCEC	TCGA	DSGPRDS	DEG_SCF_TRCP1_1	0.0833
p.T727M	DO43306	UCEC	ICGC	DSGPRDS	DEG_SCF_TRCP1_1	0.0833
p.T727M	DO43755	UCEC	ICGC	DSGPRDS	DEG_SCF_TRCP1_1	0.0833
p.P745S	DO222794	COCA	ICGC	DSGPRDS	DEG_SCF_TRCP1_1	0.25
p.F730L	DO233098	GACA	ICGC	DSGPRDS	DEG_SCF_TRCP1_1	0.1667
p.Q744R	SIDM00690	Head and Neck Carcinoma	GDSC	DSGPRDS	DEG_SCF_TRCP1_1	0.2778
p.Q744R	SIDM01318	Hepatocellular Carcinoma	GDSC	DSGPRDS	DEG_SCF_TRCP1_1	0.2778
p.Q744R	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	DSGPRDS	DEG_SCF_TRCP1_1	0.2778
p.E740K	SIDM00498	Colorectal Carcinoma	GDSC	DSGPRDS	DEG_SCF_TRCP1_1	0.7022
p.E740K	SNU-C5	large_intestine	COSMIC	DSGPRDS	DEG_SCF_TRCP1_1	0.7022
p.M748T	SIDM00132	Pancreatic Carcinoma	GDSC	DSGPRDS	DEG_SCF_TRCP1_1	0.1667
p.M748T	BxPC-3	pancreas	COSMIC	DSGPRDS	DEG_SCF_TRCP1_1	0.1667
p.R740M	ACH-000977	lymph_node	CCLE	DSGPRDS	DEG_SCF_TRCP1_1	0.7521
p.R740M	LNCaP-Clone-FGC	prostate	COSMIC	DSGPRDS	DEG_SCF_TRCP1_1	0.7521

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96PX9	Pleckstrin homology domain-containing family G member 4B	DEG_SCF_TRCP1_1	736:742	DSGPRDS	BTRC	0.7262	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons