DegronMD

Uniprot ID: Q06455

Source protein: Protein CBFA2T1

Source gene: RUNX1T1

Class: DEG_SPOP_SBC_1

Location: 565:569

E3 ligase: SPOP

DEGRON score: 0.9927

ASA_SCORE: 84.54

COIL: 0.9204

CONS_SCORE: 0.5144

DSS_SCORE: 0.7313

HELIX: 0.0406

FCONS_SCORE: 1.1079

RIG_SCORE: 0.6103

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q571R	TCGA-77-7465	LUSC	TCGA	AVSSS	DEG_SPOP_SBC_1	0.2778
p.Q570K	TCGA-AG-4009	READ	TCGA	AVSSS	DEG_SPOP_SBC_1	0.3056
p.E556D	TCGA-BS-A0UV	UCEC	TCGA	AVSSS	DEG_SPOP_SBC_1	0.0833
p.Q569K	TCGA-EE-A17Z	SKCM	TCGA	AVSSS	DEG_SPOP_SBC_1	0.6944
p.D573E	TCGA-EE-A2A0	SKCM	TCGA	AVSSS	DEG_SPOP_SBC_1	0.2222
p.Q570L	TCGA-FS-A1ZW	SKCM	TCGA	AVSSS	DEG_SPOP_SBC_1	0.3056
p.P575T	TCGA-T3-A92N	HNSC	TCGA	AVSSS	DEG_SPOP_SBC_1	0.1667
p.P561L	DO50032	BRCA	ICGC	AVSSS	DEG_SPOP_SBC_1	0.2222
p.P561L	DO223280	UCEC	ICGC	AVSSS	DEG_SPOP_SBC_1	0.2222
p.R577H	DO230347	COCA	ICGC	AVSSS	DEG_SPOP_SBC_1	0.1111
p.R577H	DO228138	PBCA	ICGC	AVSSS	DEG_SPOP_SBC_1	0.1111
p.R577H	DO232761	PBCA	ICGC	AVSSS	DEG_SPOP_SBC_1	0.1111
p.R577C	DO234461	ESAD	ICGC	AVSSS	DEG_SPOP_SBC_1	0.1111
p.R577C	DO22237	LGG	ICGC	AVSSS	DEG_SPOP_SBC_1	0.1111
p.T560S	DO49040	HNSC	ICGC	AVSSS	DEG_SPOP_SBC_1	0.1944
p.P566Q	DO23717	LUAD	ICGC	AVSSS	DEG_SPOP_SBC_1	0.7035
p.P566T	DO26530	LUSC	ICGC	AVSSS	DEG_SPOP_SBC_1	0.7031
p.R577S	DO45492	LUSC	ICGC	AVSSS	DEG_SPOP_SBC_1	0.1111
p.E573K	DO219151	LUSC	ICGC	AVSSS	DEG_SPOP_SBC_1	0.2222
p.E573K	DO37856	SKCM	ICGC	AVSSS	DEG_SPOP_SBC_1	0.2222
p.P557Q	DO219221	LUSC	ICGC	AVSSS	DEG_SPOP_SBC_1	0.1111
p.P576L	DO220906	MELA	ICGC	AVSSS	DEG_SPOP_SBC_1	0.1389
p.P576L	DO42713	UCEC	ICGC	AVSSS	DEG_SPOP_SBC_1	0.1389
p.A558P	DO34208	PACA	ICGC	AVSSS	DEG_SPOP_SBC_1	0.1389
p.G567R	DO37429	SKCM	ICGC	AVSSS	DEG_SPOP_SBC_1	0.7568
p.G567R	DO47537	SKCM	ICGC	AVSSS	DEG_SPOP_SBC_1	0.7568
p.P569S	DO48665	SKCM	ICGC	AVSSS	DEG_SPOP_SBC_1	0.6752
p.P566L	DO51271	SKCM	ICGC	AVSSS	DEG_SPOP_SBC_1	0.7582
p.T571I	DO41235	UCEC	ICGC	AVSSS	DEG_SPOP_SBC_1	0.2778
p.A560T	SIDM02015	Colorectal Carcinoma	GDSC	AVSSS	DEG_SPOP_SBC_1	0.1944
p.S573R	SIDM00155	Head and Neck Carcinoma	GDSC	AVSSS	DEG_SPOP_SBC_1	0.2222
p.S573R	PCI-38	upper_aerodigestive_tract	COSMIC	AVSSS	DEG_SPOP_SBC_1	0.2222
p.D559E	SIDM00015	Esophageal Squamous Cell Carcinoma	GDSC	AVSSS	DEG_SPOP_SBC_1	0.1667
p.S574I	ACH-000438	Lung Cancer	CCLE	AVSSS	DEG_SPOP_SBC_1	0.1944
p.S574I	LU-65	lung	COSMIC	AVSSS	DEG_SPOP_SBC_1	0.1944
p.S567R	ACH-000744	Lung Cancer	CCLE	AVSSS	DEG_SPOP_SBC_1	0.7427
p.S567R	NCI-H1623	lung	COSMIC	AVSSS	DEG_SPOP_SBC_1	0.7427
p.S574R	ACH-000951	Lung Cancer	CCLE	AVSSS	DEG_SPOP_SBC_1	0.1944
p.S574R	NCI-H2342	lung	COSMIC	AVSSS	DEG_SPOP_SBC_1	0.1944
p.P579Q	ACH-000955	Colon/Colorectal Cancer	CCLE	AVSSS	DEG_SPOP_SBC_1	0.0556
p.P579Q	SNU-407	large_intestine	COSMIC	AVSSS	DEG_SPOP_SBC_1	0.0556
p.Q558R	ACH-000983	Leukemia	CCLE	AVSSS	DEG_SPOP_SBC_1	0.1389
p.Q558R	KCL-22	haematopoietic_and_lymphoid_tissue	COSMIC	AVSSS	DEG_SPOP_SBC_1	0.1389
p.S574N	ACH-000985	Colon/Colorectal Cancer	CCLE	AVSSS	DEG_SPOP_SBC_1	0.1944
p.G577R	ACH-001136	Lung Cancer	CCLE	AVSSS	DEG_SPOP_SBC_1	0.1111
p.G577R	NCI-H187	lung	COSMIC	AVSSS	DEG_SPOP_SBC_1	0.1111
p.V566L	ACH-001622	Brain Cancer	CCLE	AVSSS	DEG_SPOP_SBC_1	0.5654
p.P559Q	SNU-407	large_intestine	COSMIC	AVSSS	DEG_SPOP_SBC_1	0.1667
p.S578R	NCI-H1623	lung	COSMIC	AVSSS	DEG_SPOP_SBC_1	0.0833
p.M560I	MEL-JUSO	skin	COSMIC	AVSSS	DEG_SPOP_SBC_1	0.1944
p.G557R	NCI-H187	lung	COSMIC	AVSSS	DEG_SPOP_SBC_1	0.1111
p.Q569R	KCL-22	haematopoietic_and_lymphoid_tissue	COSMIC	AVSSS	DEG_SPOP_SBC_1	0.7329

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P17483	Homeobox protein Hox-B4	DEG_SPOP_SBC_1	112:116	AVSSS	SPOP	0.9569	More...
P32242	Homeobox protein OTX1	DEG_SPOP_SBC_1	131:135	AVSSS	SPOP	0.9911	More...
P34910	Protein EVI2B	DEG_SPOP_SBC_1	329:333	AVSSS	SPOP	0.9223	More...
P43358	Melanoma-associated antigen 4	DEG_SPOP_SBC_1	39:43	AVSSS	SPOP	0.8472	More...
P54278	Mismatch repair endonuclease PMS2	DEG_SPOP_SBC_1	474:478	AVSSS	SPOP	0.999	More...
P84996	Protein ALEX	DEG_SPOP_SBC_1	603:607	AVSSS	SPOP	0.9965	More...
Q06455	Protein CBFA2T1	DEG_SPOP_SBC_1	565:569	AVSSS	SPOP	0.9927	More...
Q0VDD7	Break repair meiotic recombinase recruitment factor 1	DEG_SPOP_SBC_1	66:70	AVSSS	SPOP	0.9837	More...
Q13613	Myotubularin-related protein 1	DEG_SPOP_SBC_1	643:647	AVSSS	SPOP	0.8381	More...
Q15326	Zinc finger MYND domain-containing protein 11	DEG_SPOP_SBC_1	417:421	AVSSS	SPOP	0.6553	More...
Q15714	TSC22 domain family protein 1	DEG_SPOP_SBC_1	279:283	AVSSS	SPOP	0.9984	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1491:1495	AVSSS	SPOP	0.9129	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1844:1848	AVSSS	SPOP	0.8391	More...
Q8IZA0	Dyslexia-associated protein KIAA0319-like protein	DEG_SPOP_SBC_1	173:177	AVSSS	SPOP	0.8972	More...
Q8NEY8	Periphilin-1	DEG_SPOP_SBC_1	211:215	AVSSS	SPOP	0.9988	More...
Q92562	Polyphosphoinositide phosphatase	DEG_SPOP_SBC_1	753:757	AVSSS	SPOP	0.9974	More...
Q96JE9	Microtubule-associated protein 6	DEG_SPOP_SBC_1	296:300	AVSSS	SPOP	0.8997	More...
Q99973	Telomerase protein component 1	DEG_SPOP_SBC_1	1674:1678	AVSSS	SPOP	0.8128	More...
Q9H2S1	Small conductance calcium-activated potassium channel protein 2	DEG_SPOP_SBC_1	58:62	AVSSS	SPOP	0.5155	More...
Q9HCK8	Chromodomain-helicase-DNA-binding protein 8	DEG_SPOP_SBC_1	142:146	AVSSS	SPOP	0.9881	More...
Q9NSC2	Sal-like protein 1	DEG_SPOP_SBC_1	369:373	AVSSS	SPOP	0.7672	More...
Q9ULH7	Myocardin-related transcription factor B	DEG_SPOP_SBC_1	437:441	AVSSS	SPOP	0.6865	More...
Q9UPA5	Protein bassoon	DEG_SPOP_SBC_1	3392:3396	AVSSS	SPOP	0.8731	More...
Q9Y4F4	TOG array regulator of axonemal microtubules protein 1	DEG_SPOP_SBC_1	77:81	AVSSS	SPOP	0.8214	More...
Q9Y4X4	Krueppel-like factor 12	DEG_SPOP_SBC_1	95:99	AVSSS	SPOP	0.9994	More...
Q53QW1	Testis-expressed protein 44	DEG_SPOP_SBC_1	36:40	AVSSS	SPOP	0.9324	More...
Q96PX9	Pleckstrin homology domain-containing family G member 4B	DEG_SPOP_SBC_1	1174:1178	AVSSS	SPOP	0.7969	More...
P43359	Putative melanoma-associated antigen 5P	DEG_SPOP_SBC_1	38:42	AVSSS	SPOP	0.8963	More...
Q6ZRI6	Uncharacterized protein C15orf39	DEG_SPOP_SBC_1	934:938	AVSSS	SPOP	0.9935	More...
Q8IW70	Transmembrane protein 151B	DEG_SPOP_SBC_1	439:443	AVSSS	SPOP	0.8829	More...
Q8TCN5	Zinc finger protein 507	DEG_SPOP_SBC_1	860:864	AVSSS	SPOP	0.8942	More...
Q9P2C4	Transmembrane protein 181	DEG_SPOP_SBC_1	25:29	AVSSS	SPOP	0.8665	More...
Q5U5X8	Protein FAM222A	DEG_SPOP_SBC_1	109:113	AVSSS	SPOP	0.9845	More...
Q68D20	Protein PMS2CL	DEG_SPOP_SBC_1	88:92	AVSSS	SPOP	0.7454	More...
Q9NQ32	Uncharacterized protein C11orf16	DEG_SPOP_SBC_1	333:337	AVSSS	SPOP	0.8372	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: AVSSS

Degron related mutations and impact score

Drug responses associated with RUNX1T1 mutations

All proteins holding degron of AVSSS