DegronMD - P54278(PMS2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G480V	TCGA-86-8073	LUAD	TCGA	AVSSS	DEG_SPOP_SBC_1	474:478	Mutation rewiring degron network	0.2778
p.G480V	DO23624	LUAD	ICGC	AVSSS	DEG_SPOP_SBC_1	474:478	Mutation rewiring degron network	0.2778
p.V467I	TCGA-AX-A1CE	UCEC	TCGA	AVSSS	DEG_SPOP_SBC_1	474:478	Mutation rewiring degron network	0.1389
p.V467I	DO42280	UCEC	ICGC	AVSSS	DEG_SPOP_SBC_1	474:478	Mutation rewiring degron network	0.1389
p.V467I	SIDM00487	Colorectal Carcinoma	GDSC	AVSSS	DEG_SPOP_SBC_1	474:478	Mutation rewiring degron network	0.1389
p.V467I	CCK-81	large intestine	COSMIC	AVSSS	DEG_SPOP_SBC_1	474:478	Mutation rewiring degron network	0.1389
p.V501M	TCGA-BR-8081	STAD	TCGA	DSGHGST	DEG_SCF_TRCP1_1	493:499	Mutation rewiring degron network	0.2778
p.V501M	DO38795	STAD	ICGC	DSGHGST	DEG_SCF_TRCP1_1	493:499	Mutation rewiring degron network	0.2778
p.V475M	TCGA-CK-5913	COAD	TCGA	AVSSS	DEG_SPOP_SBC_1	474:478	Mutation altering degron motif	0.6097
p.V475M	DO8826	COAD	ICGC	AVSSS	DEG_SPOP_SBC_1	474:478	Mutation altering degron motif	0.6097
p.S478T	TCGA-D8-A1XQ	BRCA	TCGA	AVSSS	DEG_SPOP_SBC_1	474:478	Mutation altering degron motif	0.7116
p.S478T	DO3095	BRCA	ICGC	AVSSS	DEG_SPOP_SBC_1	474:478	Mutation altering degron motif	0.7116
p.D464N	TCGA-DK-A1A3	BLCA	TCGA	AVSSS	DEG_SPOP_SBC_1	474:478	Mutation rewiring degron network	0.0556
p.D464N	DO558	BLCA	ICGC	AVSSS	DEG_SPOP_SBC_1	474:478	Mutation rewiring degron network	0.0556
p.T485A	TCGA-EY-A1GK	UCEC	TCGA	DSGHGST	DEG_SCF_TRCP1_1	493:499	Mutation blocking phosphorylation signal	0.5556
p.T485A	TCGA-EY-A1GK	UCEC	TCGA	AVSSS	DEG_SPOP_SBC_1	474:478	Mutation blocking phosphorylation signal	0.5833
p.T485A	TCGA-VQ-A91K	STAD	TCGA	DSGHGST	DEG_SCF_TRCP1_1	493:499	Mutation blocking phosphorylation signal	0.5556
p.T485A	TCGA-VQ-A91K	STAD	TCGA	AVSSS	DEG_SPOP_SBC_1	474:478	Mutation blocking phosphorylation signal	0.5833
p.T485A	DO51785	STAD	ICGC	DSGHGST	DEG_SCF_TRCP1_1	493:499	Mutation blocking phosphorylation signal	0.5556
p.T485A	DO51785	STAD	ICGC	AVSSS	DEG_SPOP_SBC_1	474:478	Mutation blocking phosphorylation signal	0.5833
p.T485A	DO42985	UCEC	ICGC	DSGHGST	DEG_SCF_TRCP1_1	493:499	Mutation blocking phosphorylation signal	0.5556
p.T485A	DO42985	UCEC	ICGC	AVSSS	DEG_SPOP_SBC_1	474:478	Mutation blocking phosphorylation signal	0.5833
p.S494L	TCGA-HU-A4G9	STAD	TCGA	DSGHGST	DEG_SCF_TRCP1_1	493:499	Mutation altering degron motif	0.7667
p.S494L	DO47789	STAD	ICGC	DSGHGST	DEG_SCF_TRCP1_1	493:499	Mutation altering degron motif	0.7667
p.E489K	TCGA-W3-A824	SKCM	TCGA	DSGHGST	DEG_SCF_TRCP1_1	493:499	Mutation rewiring degron network	0.2222
p.E489K	DO51271	SKCM	ICGC	DSGHGST	DEG_SCF_TRCP1_1	493:499	Mutation rewiring degron network	0.2222
p.P470L	TCGA-W3-AA1R	SKCM	TCGA	AVSSS	DEG_SPOP_SBC_1	474:478	Mutation rewiring degron network	0.2222
p.P470L	DO51275	SKCM	ICGC	AVSSS	DEG_SPOP_SBC_1	474:478	Mutation rewiring degron network	0.2222
p.T485K	DO228483	BRCA	ICGC	DSGHGST	DEG_SCF_TRCP1_1	493:499	Mutation blocking phosphorylation signal	0.5556
p.T485K	DO228483	BRCA	ICGC	AVSSS	DEG_SPOP_SBC_1	474:478	Mutation blocking phosphorylation signal	0.5833
p.T485K	DO229010	COCA	ICGC	DSGHGST	DEG_SCF_TRCP1_1	493:499	Mutation blocking phosphorylation signal	0.5556
p.T485K	DO229010	COCA	ICGC	AVSSS	DEG_SPOP_SBC_1	474:478	Mutation blocking phosphorylation signal	0.5833
p.T485K	DO229013	COCA	ICGC	DSGHGST	DEG_SCF_TRCP1_1	493:499	Mutation blocking phosphorylation signal	0.5556
p.T485K	DO229013	COCA	ICGC	AVSSS	DEG_SPOP_SBC_1	474:478	Mutation blocking phosphorylation signal	0.5833
p.T485K	DO229003	COCA	ICGC	DSGHGST	DEG_SCF_TRCP1_1	493:499	Mutation blocking phosphorylation signal	0.5556
p.T485K	DO229003	COCA	ICGC	AVSSS	DEG_SPOP_SBC_1	474:478	Mutation blocking phosphorylation signal	0.5833
p.T485K	DO231140	LAML	ICGC	DSGHGST	DEG_SCF_TRCP1_1	493:499	Mutation blocking phosphorylation signal	0.5556
p.T485K	DO231140	LAML	ICGC	AVSSS	DEG_SPOP_SBC_1	474:478	Mutation blocking phosphorylation signal	0.5833
p.T485K	DO231075	LUSC	ICGC	DSGHGST	DEG_SCF_TRCP1_1	493:499	Mutation blocking phosphorylation signal	0.5556
p.T485K	DO231075	LUSC	ICGC	AVSSS	DEG_SPOP_SBC_1	474:478	Mutation blocking phosphorylation signal	0.5833
p.P470S	DO230334	COCA	ICGC	AVSSS	DEG_SPOP_SBC_1	474:478	Mutation rewiring degron network	0.2222
p.P470S	DO229016	COCA	ICGC	AVSSS	DEG_SPOP_SBC_1	474:478	Mutation rewiring degron network	0.2222
p.P470S	DO229005	COCA	ICGC	AVSSS	DEG_SPOP_SBC_1	474:478	Mutation rewiring degron network	0.2222
p.P470S	DO234285	ESAD	ICGC	AVSSS	DEG_SPOP_SBC_1	474:478	Mutation rewiring degron network	0.2222
p.P470S	DO229480	LAML	ICGC	AVSSS	DEG_SPOP_SBC_1	474:478	Mutation rewiring degron network	0.2222
p.P470S	DO231043	LUSC	ICGC	AVSSS	DEG_SPOP_SBC_1	474:478	Mutation rewiring degron network	0.2222
p.D483E	DO233778	GACA	ICGC	DSGHGST	DEG_SCF_TRCP1_1	493:499	Mutation rewiring degron network	0.0556
p.D483E	DO233778	GACA	ICGC	AVSSS	DEG_SPOP_SBC_1	474:478	Mutation rewiring degron network	0.1944
p.T485M	SIDM00952	B-Cell Non-Hodgkin's Lymphoma	GDSC	DSGHGST	DEG_SCF_TRCP1_1	493:499	Mutation blocking phosphorylation signal	0.5556
p.T485M	SIDM00952	B-Cell Non-Hodgkin's Lymphoma	GDSC	AVSSS	DEG_SPOP_SBC_1	474:478	Mutation blocking phosphorylation signal	0.5833
p.T485M	CRO-AP2	haematopoietic and lymphoid tissue	COSMIC	DSGHGST	DEG_SCF_TRCP1_1	493:499	Mutation blocking phosphorylation signal	0.5556
p.T485M	CRO-AP2	haematopoietic and lymphoid tissue	COSMIC	AVSSS	DEG_SPOP_SBC_1	474:478	Mutation blocking phosphorylation signal	0.5833
p.S500C	SIDM00690	Head and Neck Carcinoma	GDSC	DSGHGST	DEG_SCF_TRCP1_1	493:499	Mutation rewiring degron network	0.3056
p.S500C	ACH-002251	Head and Neck Cancer	CCLE	DSGHGST	DEG_SCF_TRCP1_1	493:499	Mutation rewiring degron network	0.3056
p.S500C	JHU-029	upper aerodigestive tract	COSMIC	DSGHGST	DEG_SCF_TRCP1_1	493:499	Mutation rewiring degron network	0.3056
p.E504G	SIDM00538	Esophageal Carcinoma	GDSC	DSGHGST	DEG_SCF_TRCP1_1	493:499	Mutation rewiring degron network	0.1944
p.E504G	ACH-001497	Esophageal Cancer	CCLE	DSGHGST	DEG_SCF_TRCP1_1	493:499	Mutation rewiring degron network	0.1944
p.E504G	ESO51	oesophagus	COSMIC	DSGHGST	DEG_SCF_TRCP1_1	493:499	Mutation rewiring degron network	0.1944
p.E504Q	SIDM00826	Colorectal Carcinoma	GDSC	DSGHGST	DEG_SCF_TRCP1_1	493:499	Mutation rewiring degron network	0.1944
p.E504Q	SIDM00823	Colorectal Carcinoma	GDSC	DSGHGST	DEG_SCF_TRCP1_1	493:499	Mutation rewiring degron network	0.1944
p.E504Q	ACH-000253	Colon/Colorectal Cancer	CCLE	DSGHGST	DEG_SCF_TRCP1_1	493:499	Mutation rewiring degron network	0.1944
p.E504Q	ACH-001039	Colon/Colorectal Cancer	CCLE	DSGHGST	DEG_SCF_TRCP1_1	493:499	Mutation rewiring degron network	0.1944
p.E504Q	COLO-205	large intestine	COSMIC	DSGHGST	DEG_SCF_TRCP1_1	493:499	Mutation rewiring degron network	0.1944
p.E491K	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	DSGHGST	DEG_SCF_TRCP1_1	493:499	Mutation rewiring degron network	0.2778
p.E491K	ACH-000900	Lung Cancer	CCLE	DSGHGST	DEG_SCF_TRCP1_1	493:499	Mutation rewiring degron network	0.2778
p.E491K	NCI-H23	lung	COSMIC	DSGHGST	DEG_SCF_TRCP1_1	493:499	Mutation rewiring degron network	0.2778
p.G497D	SIDM01546	Kidney Carcinoma	GDSC	DSGHGST	DEG_SCF_TRCP1_1	493:499	Mutation altering degron motif	0.6087
p.G480R	SIDM01434	Hepatocellular Carcinoma	GDSC	AVSSS	DEG_SPOP_SBC_1	474:478	Mutation rewiring degron network	0.2778
p.G480R	ACH-000316	Liver Cancer	CCLE	AVSSS	DEG_SPOP_SBC_1	474:478	Mutation rewiring degron network	0.2778
p.A466T	NALM-6	haematopoietic and lymphoid tissue	COSMIC	AVSSS	DEG_SPOP_SBC_1	474:478	Mutation rewiring degron network	0.1111
p.A466T	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	AVSSS	DEG_SPOP_SBC_1	474:478	Mutation rewiring degron network	0.1111
p.C485R	SK-MEL-2	skin	COSMIC	DSGHGST	DEG_SCF_TRCP1_1	493:499	Mutation blocking phosphorylation signal	0.5556
p.C485R	SK-MEL-2	skin	COSMIC	AVSSS	DEG_SPOP_SBC_1	474:478	Mutation blocking phosphorylation signal	0.5833
p.S481N	SK-MEL-2	skin	COSMIC	AVSSS	DEG_SPOP_SBC_1	474:478	Mutation rewiring degron network	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PMS2

UniProt ID: P54278

Entrez ID: 5395

Protein name: Mismatch repair endonuclease PMS2 (EC 3.1.-.-) (DNA mismatch repair protein PMS2) (PMS1 protein homolog 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PMS2 in