DegronMD

Uniprot ID: P54278

Source protein: Mismatch repair endonuclease PMS2

Source gene: PMS2

Class: DEG_SPOP_SBC_1

Location: 474:478

E3 ligase: SPOP

DEGRON score: 0.999

ASA_SCORE: 77.12

COIL: 0.8282

CONS_SCORE: 0.256

DSS_SCORE: 0.7672

HELIX: 0.1378

FCONS_SCORE: 1.1798

RIG_SCORE: 0.5633

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G480V	TCGA-86-8073	LUAD	TCGA	AVSSS	DEG_SPOP_SBC_1	0.2778
p.G480V	DO23624	LUAD	ICGC	AVSSS	DEG_SPOP_SBC_1	0.2778
p.V467I	TCGA-AX-A1CE	UCEC	TCGA	AVSSS	DEG_SPOP_SBC_1	0.1389
p.V467I	DO42280	UCEC	ICGC	AVSSS	DEG_SPOP_SBC_1	0.1389
p.V467I	SIDM00487	Colorectal Carcinoma	GDSC	AVSSS	DEG_SPOP_SBC_1	0.1389
p.V467I	CCK-81	large_intestine	COSMIC	AVSSS	DEG_SPOP_SBC_1	0.1389
p.V475M	TCGA-CK-5913	COAD	TCGA	AVSSS	DEG_SPOP_SBC_1	0.6097
p.V475M	DO8826	COAD	ICGC	AVSSS	DEG_SPOP_SBC_1	0.6097
p.S478T	TCGA-D8-A1XQ	BRCA	TCGA	AVSSS	DEG_SPOP_SBC_1	0.7116
p.S478T	DO3095	BRCA	ICGC	AVSSS	DEG_SPOP_SBC_1	0.7116
p.D464N	TCGA-DK-A1A3	BLCA	TCGA	AVSSS	DEG_SPOP_SBC_1	0.0556
p.D464N	DO558	BLCA	ICGC	AVSSS	DEG_SPOP_SBC_1	0.0556
p.T485A	TCGA-EY-A1GK	UCEC	TCGA	AVSSS	DEG_SPOP_SBC_1	0.5833
p.T485A	TCGA-VQ-A91K	STAD	TCGA	AVSSS	DEG_SPOP_SBC_1	0.5833
p.T485A	DO51785	STAD	ICGC	AVSSS	DEG_SPOP_SBC_1	0.5833
p.T485A	DO42985	UCEC	ICGC	AVSSS	DEG_SPOP_SBC_1	0.5833
p.P470L	TCGA-W3-AA1R	SKCM	TCGA	AVSSS	DEG_SPOP_SBC_1	0.2222
p.P470L	DO51275	SKCM	ICGC	AVSSS	DEG_SPOP_SBC_1	0.2222
p.T485K	DO228483	BRCA	ICGC	AVSSS	DEG_SPOP_SBC_1	0.5833
p.T485K	DO229010	COCA	ICGC	AVSSS	DEG_SPOP_SBC_1	0.5833
p.T485K	DO229013	COCA	ICGC	AVSSS	DEG_SPOP_SBC_1	0.5833
p.T485K	DO229003	COCA	ICGC	AVSSS	DEG_SPOP_SBC_1	0.5833
p.T485K	DO231140	LAML	ICGC	AVSSS	DEG_SPOP_SBC_1	0.5833
p.T485K	DO231075	LUSC	ICGC	AVSSS	DEG_SPOP_SBC_1	0.5833
p.P470S	DO230334	COCA	ICGC	AVSSS	DEG_SPOP_SBC_1	0.2222
p.P470S	DO229016	COCA	ICGC	AVSSS	DEG_SPOP_SBC_1	0.2222
p.P470S	DO229005	COCA	ICGC	AVSSS	DEG_SPOP_SBC_1	0.2222
p.P470S	DO234285	ESAD	ICGC	AVSSS	DEG_SPOP_SBC_1	0.2222
p.P470S	DO229480	LAML	ICGC	AVSSS	DEG_SPOP_SBC_1	0.2222
p.P470S	DO231043	LUSC	ICGC	AVSSS	DEG_SPOP_SBC_1	0.2222
p.D483E	DO233778	GACA	ICGC	AVSSS	DEG_SPOP_SBC_1	0.1944
p.T485M	SIDM00952	B-Cell Non-Hodgkin's Lymphoma	GDSC	AVSSS	DEG_SPOP_SBC_1	0.5833
p.T485M	CRO-AP2	haematopoietic_and_lymphoid_tissue	COSMIC	AVSSS	DEG_SPOP_SBC_1	0.5833
p.G480R	SIDM01434	Hepatocellular Carcinoma	GDSC	AVSSS	DEG_SPOP_SBC_1	0.2778
p.G480R	ACH-000316	Liver Cancer	CCLE	AVSSS	DEG_SPOP_SBC_1	0.2778
p.A466T	NALM-6	haematopoietic_and_lymphoid_tissue	COSMIC	AVSSS	DEG_SPOP_SBC_1	0.1111
p.A466T	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	AVSSS	DEG_SPOP_SBC_1	0.1111
p.C485R	SK-MEL-2	skin	COSMIC	AVSSS	DEG_SPOP_SBC_1	0.5833
p.S481N	SK-MEL-2	skin	COSMIC	AVSSS	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P17483	Homeobox protein Hox-B4	DEG_SPOP_SBC_1	112:116	AVSSS	SPOP	0.9569	More...
P32242	Homeobox protein OTX1	DEG_SPOP_SBC_1	131:135	AVSSS	SPOP	0.9911	More...
P34910	Protein EVI2B	DEG_SPOP_SBC_1	329:333	AVSSS	SPOP	0.9223	More...
P43358	Melanoma-associated antigen 4	DEG_SPOP_SBC_1	39:43	AVSSS	SPOP	0.8472	More...
P54278	Mismatch repair endonuclease PMS2	DEG_SPOP_SBC_1	474:478	AVSSS	SPOP	0.999	More...
P84996	Protein ALEX	DEG_SPOP_SBC_1	603:607	AVSSS	SPOP	0.9965	More...
Q06455	Protein CBFA2T1	DEG_SPOP_SBC_1	565:569	AVSSS	SPOP	0.9927	More...
Q0VDD7	Break repair meiotic recombinase recruitment factor 1	DEG_SPOP_SBC_1	66:70	AVSSS	SPOP	0.9837	More...
Q13613	Myotubularin-related protein 1	DEG_SPOP_SBC_1	643:647	AVSSS	SPOP	0.8381	More...
Q15326	Zinc finger MYND domain-containing protein 11	DEG_SPOP_SBC_1	417:421	AVSSS	SPOP	0.6553	More...
Q15714	TSC22 domain family protein 1	DEG_SPOP_SBC_1	279:283	AVSSS	SPOP	0.9984	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1491:1495	AVSSS	SPOP	0.9129	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1844:1848	AVSSS	SPOP	0.8391	More...
Q8IZA0	Dyslexia-associated protein KIAA0319-like protein	DEG_SPOP_SBC_1	173:177	AVSSS	SPOP	0.8972	More...
Q8NEY8	Periphilin-1	DEG_SPOP_SBC_1	211:215	AVSSS	SPOP	0.9988	More...
Q92562	Polyphosphoinositide phosphatase	DEG_SPOP_SBC_1	753:757	AVSSS	SPOP	0.9974	More...
Q96JE9	Microtubule-associated protein 6	DEG_SPOP_SBC_1	296:300	AVSSS	SPOP	0.8997	More...
Q99973	Telomerase protein component 1	DEG_SPOP_SBC_1	1674:1678	AVSSS	SPOP	0.8128	More...
Q9H2S1	Small conductance calcium-activated potassium channel protein 2	DEG_SPOP_SBC_1	58:62	AVSSS	SPOP	0.5155	More...
Q9HCK8	Chromodomain-helicase-DNA-binding protein 8	DEG_SPOP_SBC_1	142:146	AVSSS	SPOP	0.9881	More...
Q9NSC2	Sal-like protein 1	DEG_SPOP_SBC_1	369:373	AVSSS	SPOP	0.7672	More...
Q9ULH7	Myocardin-related transcription factor B	DEG_SPOP_SBC_1	437:441	AVSSS	SPOP	0.6865	More...
Q9UPA5	Protein bassoon	DEG_SPOP_SBC_1	3392:3396	AVSSS	SPOP	0.8731	More...
Q9Y4F4	TOG array regulator of axonemal microtubules protein 1	DEG_SPOP_SBC_1	77:81	AVSSS	SPOP	0.8214	More...
Q9Y4X4	Krueppel-like factor 12	DEG_SPOP_SBC_1	95:99	AVSSS	SPOP	0.9994	More...
Q53QW1	Testis-expressed protein 44	DEG_SPOP_SBC_1	36:40	AVSSS	SPOP	0.9324	More...
Q96PX9	Pleckstrin homology domain-containing family G member 4B	DEG_SPOP_SBC_1	1174:1178	AVSSS	SPOP	0.7969	More...
P43359	Putative melanoma-associated antigen 5P	DEG_SPOP_SBC_1	38:42	AVSSS	SPOP	0.8963	More...
Q6ZRI6	Uncharacterized protein C15orf39	DEG_SPOP_SBC_1	934:938	AVSSS	SPOP	0.9935	More...
Q8IW70	Transmembrane protein 151B	DEG_SPOP_SBC_1	439:443	AVSSS	SPOP	0.8829	More...
Q8TCN5	Zinc finger protein 507	DEG_SPOP_SBC_1	860:864	AVSSS	SPOP	0.8942	More...
Q9P2C4	Transmembrane protein 181	DEG_SPOP_SBC_1	25:29	AVSSS	SPOP	0.8665	More...
Q5U5X8	Protein FAM222A	DEG_SPOP_SBC_1	109:113	AVSSS	SPOP	0.9845	More...
Q68D20	Protein PMS2CL	DEG_SPOP_SBC_1	88:92	AVSSS	SPOP	0.7454	More...
Q9NQ32	Uncharacterized protein C11orf16	DEG_SPOP_SBC_1	333:337	AVSSS	SPOP	0.8372	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: AVSSS

Degron related mutations and impact score

Drug responses associated with PMS2 mutations

All proteins holding degron of AVSSS