DegronMD - Q9NQ32(C11orf16)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K452N	TCGA-21-1082	LUSC	TCGA	PPRTPPGE	DEG_SCF_FBW7_2	440:447	Mutation substituting flanking lysine	0.3056
p.K452N	DO26463	LUSC	ICGC	PPRTPPGE	DEG_SCF_FBW7_2	440:447	Mutation substituting flanking lysine	0.3056
p.G446E	TCGA-38-6178	LUAD	TCGA	PPRTPPGE	DEG_SCF_FBW7_2	440:447	Mutation altering degron motif	0.6087
p.G446E	TCGA-EE-A29D	SKCM	TCGA	PPRTPPGE	DEG_SCF_FBW7_2	440:447	Mutation altering degron motif	0.6087
p.G446E	DO23842	LUAD	ICGC	PPRTPPGE	DEG_SCF_FBW7_2	440:447	Mutation altering degron motif	0.6087
p.G446E	DO38123	SKCM	ICGC	PPRTPPGE	DEG_SCF_FBW7_2	440:447	Mutation altering degron motif	0.6087
p.E324Q	TCGA-CV-7101	HNSC	TCGA	AVSSS	DEG_SPOP_SBC_1	333:337	Mutation rewiring degron network	0.0833
p.E324Q	DO15310	HNSC	ICGC	AVSSS	DEG_SPOP_SBC_1	333:337	Mutation rewiring degron network	0.0833
p.M328T	TCGA-EI-6917	READ	TCGA	AVSSS	DEG_SPOP_SBC_1	333:337	Mutation rewiring degron network	0.1944
p.M328T	DO36881	READ	ICGC	AVSSS	DEG_SPOP_SBC_1	333:337	Mutation rewiring degron network	0.1944
p.P441L	TCGA-FS-A1ZQ	SKCM	TCGA	PPRTPPGE	DEG_SCF_FBW7_2	440:447	Mutation altering degron motif	0.6471
p.P441L	DO37442	SKCM	ICGC	PPRTPPGE	DEG_SCF_FBW7_2	440:447	Mutation altering degron motif	0.6471
p.E324K	TCGA-FW-A3TU	SKCM	TCGA	AVSSS	DEG_SPOP_SBC_1	333:337	Mutation rewiring degron network	0.0833
p.E324K	DO220903	MELA	ICGC	AVSSS	DEG_SPOP_SBC_1	333:337	Mutation rewiring degron network	0.0833
p.E324K	DO37441	SKCM	ICGC	AVSSS	DEG_SPOP_SBC_1	333:337	Mutation rewiring degron network	0.0833
p.E343K	TCGA-UY-A78M	BLCA	TCGA	AVSSS	DEG_SPOP_SBC_1	333:337	Mutation rewiring degron network	0.1667
p.E343K	DO219033	BLCA	ICGC	AVSSS	DEG_SPOP_SBC_1	333:337	Mutation rewiring degron network	0.1667
p.R442Q	DO230334	COCA	ICGC	PPRTPPGE	DEG_SCF_FBW7_2	440:447	Mutation altering degron motif	0.6218
p.R442Q	DO229010	COCA	ICGC	PPRTPPGE	DEG_SCF_FBW7_2	440:447	Mutation altering degron motif	0.6218
p.R442Q	DO229013	COCA	ICGC	PPRTPPGE	DEG_SCF_FBW7_2	440:447	Mutation altering degron motif	0.6218
p.R442Q	DO229003	COCA	ICGC	PPRTPPGE	DEG_SCF_FBW7_2	440:447	Mutation altering degron motif	0.6218
p.A435V	DO223068	ESCA	ICGC	PPRTPPGE	DEG_SCF_FBW7_2	440:447	Mutation rewiring degron network	0.1944
p.A435E	DO229018	LICA	ICGC	PPRTPPGE	DEG_SCF_FBW7_2	440:447	Mutation rewiring degron network	0.1944
p.P440Q	DO229029	LICA	ICGC	PPRTPPGE	DEG_SCF_FBW7_2	440:447	Mutation altering degron motif	0.7035
p.Q344K	DO229022	LICA	ICGC	AVSSS	DEG_SPOP_SBC_1	333:337	Mutation rewiring degron network	0.1389
p.P441Q	DO229024	LICA	ICGC	PPRTPPGE	DEG_SCF_FBW7_2	440:447	Mutation altering degron motif	0.5924
p.P440T	DO229036	LICA	ICGC	PPRTPPGE	DEG_SCF_FBW7_2	440:447	Mutation altering degron motif	0.7031
p.A435T	DO50756	LICA	ICGC	PPRTPPGE	DEG_SCF_FBW7_2	440:447	Mutation rewiring degron network	0.1944
p.S337F	DO220851	MELA	ICGC	AVSSS	DEG_SPOP_SBC_1	333:337	Mutation altering degron motif	0.7982
p.M438I	DO220911	MELA	ICGC	PPRTPPGE	DEG_SCF_FBW7_2	440:447	Mutation rewiring degron network	0.2778
p.E430K	SIDM00007	Other Solid Cancers	GDSC	PPRTPPGE	DEG_SCF_FBW7_2	440:447	Mutation rewiring degron network	0.0556
p.E430K	ACH-001550	Skin Cancer	CCLE	PPRTPPGE	DEG_SCF_FBW7_2	440:447	Mutation rewiring degron network	0.0556
p.G346S	SIDM00741	Small Cell Lung Carcinoma	GDSC	AVSSS	DEG_SPOP_SBC_1	333:337	Mutation rewiring degron network	0.0833
p.S335Y	SIDM00193	Colorectal Carcinoma	GDSC	AVSSS	DEG_SPOP_SBC_1	333:337	Mutation altering degron motif	0.712
p.S335Y	ACH-000991	Colon/Colorectal Cancer	CCLE	AVSSS	DEG_SPOP_SBC_1	333:337	Mutation altering degron motif	0.712

DegronMD: protein-targeted degradation, mutation and drug response to degrons

C11orf16

UniProt ID: Q9NQ32

Entrez ID: 56673

Protein name: Uncharacterized protein C11orf16

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for C11orf16 in