DegronMD

Uniprot ID: Q9NQ32

Source protein: Uncharacterized protein C11orf16

Source gene: C11orf16

Class: DEG_SCF_FBW7_2

Location: 440:447

E3 ligase: FBXW7

DEGRON score: 0.8964

ASA_SCORE: 80.9375

COIL: 0.873

CONS_SCORE: 0.3948

DSS_SCORE: 0.8001

HELIX: 0.114

FCONS_SCORE: 1.0442

RIG_SCORE: 0.5846

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K452N	TCGA-21-1082	LUSC	TCGA	PPRTPPGE	DEG_SCF_FBW7_2	0.3056
p.K452N	DO26463	LUSC	ICGC	PPRTPPGE	DEG_SCF_FBW7_2	0.3056
p.G446E	TCGA-38-6178	LUAD	TCGA	PPRTPPGE	DEG_SCF_FBW7_2	0.6087
p.G446E	TCGA-EE-A29D	SKCM	TCGA	PPRTPPGE	DEG_SCF_FBW7_2	0.6087
p.G446E	DO23842	LUAD	ICGC	PPRTPPGE	DEG_SCF_FBW7_2	0.6087
p.G446E	DO38123	SKCM	ICGC	PPRTPPGE	DEG_SCF_FBW7_2	0.6087
p.P441L	TCGA-FS-A1ZQ	SKCM	TCGA	PPRTPPGE	DEG_SCF_FBW7_2	0.6471
p.P441L	DO37442	SKCM	ICGC	PPRTPPGE	DEG_SCF_FBW7_2	0.6471
p.R442Q	DO230334	COCA	ICGC	PPRTPPGE	DEG_SCF_FBW7_2	0.6218
p.R442Q	DO229010	COCA	ICGC	PPRTPPGE	DEG_SCF_FBW7_2	0.6218
p.R442Q	DO229013	COCA	ICGC	PPRTPPGE	DEG_SCF_FBW7_2	0.6218
p.R442Q	DO229003	COCA	ICGC	PPRTPPGE	DEG_SCF_FBW7_2	0.6218
p.A435V	DO223068	ESCA	ICGC	PPRTPPGE	DEG_SCF_FBW7_2	0.1944
p.A435E	DO229018	LICA	ICGC	PPRTPPGE	DEG_SCF_FBW7_2	0.1944
p.P440Q	DO229029	LICA	ICGC	PPRTPPGE	DEG_SCF_FBW7_2	0.7035
p.P441Q	DO229024	LICA	ICGC	PPRTPPGE	DEG_SCF_FBW7_2	0.5924
p.P440T	DO229036	LICA	ICGC	PPRTPPGE	DEG_SCF_FBW7_2	0.7031
p.A435T	DO50756	LICA	ICGC	PPRTPPGE	DEG_SCF_FBW7_2	0.1944
p.M438I	DO220911	MELA	ICGC	PPRTPPGE	DEG_SCF_FBW7_2	0.2778
p.E430K	SIDM00007	Other Solid Cancers	GDSC	PPRTPPGE	DEG_SCF_FBW7_2	0.0556
p.E430K	ACH-001550	Skin Cancer	CCLE	PPRTPPGE	DEG_SCF_FBW7_2	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NQ32	Uncharacterized protein C11orf16	DEG_SCF_FBW7_2	440:447	PPRTPPGE	FBXW7	0.8964	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons