DegronMD - Q15326(ZMYND11)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S419R	TCGA-AR-A0TZ	BRCA	TCGA	AVSSS	DEG_SPOP_SBC_1	417:421	Mutation altering degron motif	0.7427
p.S419R	SIDM00941	Kidney Carcinoma	GDSC	AVSSS	DEG_SPOP_SBC_1	417:421	Mutation altering degron motif	0.7427
p.S419R	ACH-000433	Kidney Cancer	CCLE	AVSSS	DEG_SPOP_SBC_1	417:421	Mutation altering degron motif	0.7427
p.S419R	CAKI-1	kidney	COSMIC	AVSSS	DEG_SPOP_SBC_1	417:421	Mutation altering degron motif	0.7427
p.S421R	TCGA-AR-A0TZ	BRCA	TCGA	AVSSS	DEG_SPOP_SBC_1	417:421	Mutation altering degron motif	0.8538
p.E414K	TCGA-BB-4224	HNSC	TCGA	AVSSS	DEG_SPOP_SBC_1	417:421	Mutation rewiring degron network	0.25
p.S420C	TCGA-K4-A54R	BLCA	TCGA	AVSSS	DEG_SPOP_SBC_1	417:421	Mutation altering degron motif	0.7541
p.N419K	DO225339	BRCA	ICGC	AVSSS	DEG_SPOP_SBC_1	417:421	Mutation altering degron motif	0.6918
p.V422A	DO228091	EOPC	ICGC	AVSSS	DEG_SPOP_SBC_1	417:421	Mutation rewiring degron network	0.3056
p.H412R	DO23561	LUAD	ICGC	AVSSS	DEG_SPOP_SBC_1	417:421	Mutation rewiring degron network	0.1944
p.V422M	DO32307	OV	ICGC	AVSSS	DEG_SPOP_SBC_1	417:421	Mutation rewiring degron network	0.3056
p.Q416R	DO46657	PAAD	ICGC	AVSSS	DEG_SPOP_SBC_1	417:421	Mutation rewiring degron network	0.3056
p.R409I	DO232761	PBCA	ICGC	AVSSS	DEG_SPOP_SBC_1	417:421	Mutation rewiring degron network	0.1111
p.Q416K	DO47407	SKCM	ICGC	AVSSS	DEG_SPOP_SBC_1	417:421	Mutation rewiring degron network	0.3056
p.D420N	DO52402	UCEC	ICGC	AVSSS	DEG_SPOP_SBC_1	417:421	Mutation altering degron motif	0.6932
p.S420Y	SIDM00490	Glioma	GDSC	AVSSS	DEG_SPOP_SBC_1	417:421	Mutation altering degron motif	0.712
p.S420Y	ACH-001016	Brain Cancer	CCLE	AVSSS	DEG_SPOP_SBC_1	417:421	Mutation altering degron motif	0.712
p.S420Y	Becker	central nervous system	COSMIC	AVSSS	DEG_SPOP_SBC_1	417:421	Mutation altering degron motif	0.712
p.H431Y	COLO-684	endometrium	COSMIC	AVSSS	DEG_SPOP_SBC_1	417:421	Mutation rewiring degron network	0.0556
p.S419Y	Becker	central nervous system	COSMIC	AVSSS	DEG_SPOP_SBC_1	417:421	Mutation altering degron motif	0.712
p.V419M	SBC-1	lung	COSMIC	AVSSS	DEG_SPOP_SBC_1	417:421	Mutation altering degron motif	0.7208
p.S418R	CAKI-1	kidney	COSMIC	AVSSS	DEG_SPOP_SBC_1	417:421	Mutation altering degron motif	0.7427
p.T426I	AU565	breast	COSMIC	AVSSS	DEG_SPOP_SBC_1	417:421	Mutation rewiring degron network	0.1944

Kaplan plot for ZMYND11 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZMYND11

UniProt ID: Q15326

Entrez ID: 10771

Protein name: Zinc finger MYND domain-containing protein 11 (Adenovirus 5 E1A-binding protein) (Bone morphogenetic protein receptor-associated molecule 1) (Protein BS69)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZMYND11 in