DegronMD

Uniprot ID: Q15326

Source protein: Zinc finger MYND domain-containing protein 11

Source gene: ZMYND11

Class: DEG_SPOP_SBC_1

Location: 417:421

E3 ligase: SPOP

DEGRON score: 0.6553

ASA_SCORE: 69.86

COIL: 0.724

CONS_SCORE: 0.3479

DSS_SCORE: 0.7479

HELIX: 0.2384

FCONS_SCORE: 0.8875

RIG_SCORE: 0.6216

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S421R	TCGA-AR-A0TZ	BRCA	TCGA	AVSSS	DEG_SPOP_SBC_1	0.8538
p.S420C	TCGA-K4-A54R	BLCA	TCGA	AVSSS	DEG_SPOP_SBC_1	0.7541
p.S419R	TCGA-AR-A0TZ	BRCA	TCGA	AVSSS	DEG_SPOP_SBC_1	0.7427
p.S419R	SIDM00941	Kidney Carcinoma	GDSC	AVSSS	DEG_SPOP_SBC_1	0.7427
p.S419R	ACH-000433	Kidney Cancer	CCLE	AVSSS	DEG_SPOP_SBC_1	0.7427
p.S419R	CAKI-1	kidney	COSMIC	AVSSS	DEG_SPOP_SBC_1	0.7427
p.S418R	CAKI-1	kidney	COSMIC	AVSSS	DEG_SPOP_SBC_1	0.7427
p.V419M	SBC-1	lung	COSMIC	AVSSS	DEG_SPOP_SBC_1	0.7208
p.S420Y	SIDM00490	Glioma	GDSC	AVSSS	DEG_SPOP_SBC_1	0.712
p.S420Y	ACH-001016	Brain Cancer	CCLE	AVSSS	DEG_SPOP_SBC_1	0.712
p.S420Y	Becker	central_nervous_system	COSMIC	AVSSS	DEG_SPOP_SBC_1	0.712
p.S419Y	Becker	central_nervous_system	COSMIC	AVSSS	DEG_SPOP_SBC_1	0.712
p.D420N	DO52402	UCEC	ICGC	AVSSS	DEG_SPOP_SBC_1	0.6932
p.N419K	DO225339	BRCA	ICGC	AVSSS	DEG_SPOP_SBC_1	0.6918
p.V422A	DO228091	EOPC	ICGC	AVSSS	DEG_SPOP_SBC_1	0.3056
p.V422M	DO32307	OV	ICGC	AVSSS	DEG_SPOP_SBC_1	0.3056
p.Q416R	DO46657	PAAD	ICGC	AVSSS	DEG_SPOP_SBC_1	0.3056
p.Q416K	DO47407	SKCM	ICGC	AVSSS	DEG_SPOP_SBC_1	0.3056
p.E414K	TCGA-BB-4224	HNSC	TCGA	AVSSS	DEG_SPOP_SBC_1	0.25
p.H412R	DO23561	LUAD	ICGC	AVSSS	DEG_SPOP_SBC_1	0.1944
p.T426I	AU565	breast	COSMIC	AVSSS	DEG_SPOP_SBC_1	0.1944
p.R409I	DO232761	PBCA	ICGC	AVSSS	DEG_SPOP_SBC_1	0.1111
p.H431Y	COLO-684	endometrium	COSMIC	AVSSS	DEG_SPOP_SBC_1	0.0556

Showing 1 to 23 of 23 entries

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Drug responses associated with ZMYND11 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of AVSSS

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q0VDD7	Break repair meiotic recombinase recruitment factor 1	DEG_SPOP_SBC_1	66:70	AVSSS	SPOP	0.9837	More...
Q9HCK8	Chromodomain-helicase-DNA-binding protein 8	DEG_SPOP_SBC_1	142:146	AVSSS	SPOP	0.9881	More...
Q8IZA0	Dyslexia-associated protein KIAA0319-like protein	DEG_SPOP_SBC_1	173:177	AVSSS	SPOP	0.8972	More...
P17483	Homeobox protein Hox-B4	DEG_SPOP_SBC_1	112:116	AVSSS	SPOP	0.9569	More...
P32242	Homeobox protein OTX1	DEG_SPOP_SBC_1	131:135	AVSSS	SPOP	0.9911	More...
Q9Y4X4	Krueppel-like factor 12	DEG_SPOP_SBC_1	95:99	AVSSS	SPOP	0.9994	More...
P43358	Melanoma-associated antigen 4	DEG_SPOP_SBC_1	39:43	AVSSS	SPOP	0.8472	More...
Q96JE9	Microtubule-associated protein 6	DEG_SPOP_SBC_1	296:300	AVSSS	SPOP	0.8997	More...
P54278	Mismatch repair endonuclease PMS2	DEG_SPOP_SBC_1	474:478	AVSSS	SPOP	0.999	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1491:1495	AVSSS	SPOP	0.9129	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1844:1848	AVSSS	SPOP	0.8391	More...
Q9ULH7	Myocardin-related transcription factor B	DEG_SPOP_SBC_1	437:441	AVSSS	SPOP	0.6865	More...
Q13613	Myotubularin-related protein 1	DEG_SPOP_SBC_1	643:647	AVSSS	SPOP	0.8381	More...
Q8NEY8	Periphilin-1	DEG_SPOP_SBC_1	211:215	AVSSS	SPOP	0.9988	More...
Q96PX9	Pleckstrin homology domain-containing family G member 4B	DEG_SPOP_SBC_1	1174:1178	AVSSS	SPOP	0.7969	More...
Q92562	Polyphosphoinositide phosphatase	DEG_SPOP_SBC_1	753:757	AVSSS	SPOP	0.9974	More...
P84996	Protein ALEX	DEG_SPOP_SBC_1	603:607	AVSSS	SPOP	0.9965	More...
Q9UPA5	Protein bassoon	DEG_SPOP_SBC_1	3392:3396	AVSSS	SPOP	0.8731	More...
Q06455	Protein CBFA2T1	DEG_SPOP_SBC_1	565:569	AVSSS	SPOP	0.9927	More...
P34910	Protein EVI2B	DEG_SPOP_SBC_1	329:333	AVSSS	SPOP	0.9223	More...
Q5U5X8	Protein FAM222A	DEG_SPOP_SBC_1	109:113	AVSSS	SPOP	0.9845	More...
Q68D20	Protein PMS2CL	DEG_SPOP_SBC_1	88:92	AVSSS	SPOP	0.7454	More...
P43359	Putative melanoma-associated antigen 5P	DEG_SPOP_SBC_1	38:42	AVSSS	SPOP	0.8963	More...
Q9NSC2	Sal-like protein 1	DEG_SPOP_SBC_1	369:373	AVSSS	SPOP	0.7672	More...
Q9H2S1	Small conductance calcium-activated potassium channel protein 2	DEG_SPOP_SBC_1	58:62	AVSSS	SPOP	0.5155	More...

Showing 1 to 25 of 35 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: AVSSS

Degron related mutations and impact score

Drug responses associated with ZMYND11 mutations

All proteins holding degron of AVSSS