DegronMD

Uniprot ID: P43358

Source protein: Melanoma-associated antigen 4

Source gene: MAGEA4

Class: DEG_SPOP_SBC_1

Location: 39:43

E3 ligase: SPOP

DEGRON score: 0.8472

ASA_SCORE: 66.42

COIL: 0.8724

CONS_SCORE: 0.4457

DSS_SCORE: 0.7044

HELIX: 0.0672

FCONS_SCORE: 1.0014

RIG_SCORE: 0.6344

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S43F	TCGA-YG-AA3N	SKCM	TCGA	AVSSS	DEG_SPOP_SBC_1	0.7982
p.S43F	DO51298	SKCM	ICGC	AVSSS	DEG_SPOP_SBC_1	0.7982
p.S43F	ACH-001302	Neuroblastoma	CCLE	AVSSS	DEG_SPOP_SBC_1	0.7982
p.A39S	TCGA-50-5946	LUAD	TCGA	AVSSS	DEG_SPOP_SBC_1	0.7588
p.A39S	DO24556	LUAD	ICGC	AVSSS	DEG_SPOP_SBC_1	0.7588
p.P45S	TCGA-FR-A7UA	SKCM	TCGA	AVSSS	DEG_SPOP_SBC_1	0.2778
p.P45S	DO51253	SKCM	ICGC	AVSSS	DEG_SPOP_SBC_1	0.2778
p.P45H	SIDM00863	Burkitt's Lymphoma	GDSC	AVSSS	DEG_SPOP_SBC_1	0.2778
p.P45H	ACH-001064	Lymphoma	CCLE	AVSSS	DEG_SPOP_SBC_1	0.2778
p.P45H	EB2	haematopoietic_and_lymphoid_tissue	COSMIC	AVSSS	DEG_SPOP_SBC_1	0.2778
p.L46V	TCGA-RY-A83Z	LGG	TCGA	AVSSS	DEG_SPOP_SBC_1	0.25
p.L46V	DO219839	LGG	ICGC	AVSSS	DEG_SPOP_SBC_1	0.25
p.E34K	TCGA-G2-AA3B	BLCA	TCGA	AVSSS	DEG_SPOP_SBC_1	0.1944
p.E34K	DO51882	BLCA	ICGC	AVSSS	DEG_SPOP_SBC_1	0.1944
p.P48T	TCGA-XK-AAIW	PRAD	TCGA	AVSSS	DEG_SPOP_SBC_1	0.1944
p.P48T	DO51407	PRAD	ICGC	AVSSS	DEG_SPOP_SBC_1	0.1944
p.P31A	DO231169	LUSC	ICGC	AVSSS	DEG_SPOP_SBC_1	0.1111
p.P31S	SIDM00621	Ewing's Sarcoma	GDSC	AVSSS	DEG_SPOP_SBC_1	0.1111
p.E52K	TCGA-A2-A0YK	BRCA	TCGA	AVSSS	DEG_SPOP_SBC_1	0.0833
p.E52K	DO2836	BRCA	ICGC	AVSSS	DEG_SPOP_SBC_1	0.0833
p.Q29K	TCGA-44-6774	LUAD	TCGA	AVSSS	DEG_SPOP_SBC_1	0.0556
p.Q29K	DO25000	LUAD	ICGC	AVSSS	DEG_SPOP_SBC_1	0.0556
p.E53K	TCGA-FS-A1ZZ	SKCM	TCGA	AVSSS	DEG_SPOP_SBC_1	0.0556
p.E53K	DO222420	MELA	ICGC	AVSSS	DEG_SPOP_SBC_1	0.0556
p.E53K	DO222753	MELA	ICGC	AVSSS	DEG_SPOP_SBC_1	0.0556

Showing 1 to 25 of 27 entries

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Drug responses associated with MAGEA4 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of AVSSS

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q0VDD7	Break repair meiotic recombinase recruitment factor 1	DEG_SPOP_SBC_1	66:70	AVSSS	SPOP	0.9837	More...
Q9HCK8	Chromodomain-helicase-DNA-binding protein 8	DEG_SPOP_SBC_1	142:146	AVSSS	SPOP	0.9881	More...
Q8IZA0	Dyslexia-associated protein KIAA0319-like protein	DEG_SPOP_SBC_1	173:177	AVSSS	SPOP	0.8972	More...
P17483	Homeobox protein Hox-B4	DEG_SPOP_SBC_1	112:116	AVSSS	SPOP	0.9569	More...
P32242	Homeobox protein OTX1	DEG_SPOP_SBC_1	131:135	AVSSS	SPOP	0.9911	More...
Q9Y4X4	Krueppel-like factor 12	DEG_SPOP_SBC_1	95:99	AVSSS	SPOP	0.9994	More...
P43358	Melanoma-associated antigen 4	DEG_SPOP_SBC_1	39:43	AVSSS	SPOP	0.8472	More...
Q96JE9	Microtubule-associated protein 6	DEG_SPOP_SBC_1	296:300	AVSSS	SPOP	0.8997	More...
P54278	Mismatch repair endonuclease PMS2	DEG_SPOP_SBC_1	474:478	AVSSS	SPOP	0.999	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1491:1495	AVSSS	SPOP	0.9129	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1844:1848	AVSSS	SPOP	0.8391	More...
Q9ULH7	Myocardin-related transcription factor B	DEG_SPOP_SBC_1	437:441	AVSSS	SPOP	0.6865	More...
Q13613	Myotubularin-related protein 1	DEG_SPOP_SBC_1	643:647	AVSSS	SPOP	0.8381	More...
Q8NEY8	Periphilin-1	DEG_SPOP_SBC_1	211:215	AVSSS	SPOP	0.9988	More...
Q96PX9	Pleckstrin homology domain-containing family G member 4B	DEG_SPOP_SBC_1	1174:1178	AVSSS	SPOP	0.7969	More...
Q92562	Polyphosphoinositide phosphatase	DEG_SPOP_SBC_1	753:757	AVSSS	SPOP	0.9974	More...
P84996	Protein ALEX	DEG_SPOP_SBC_1	603:607	AVSSS	SPOP	0.9965	More...
Q9UPA5	Protein bassoon	DEG_SPOP_SBC_1	3392:3396	AVSSS	SPOP	0.8731	More...
Q06455	Protein CBFA2T1	DEG_SPOP_SBC_1	565:569	AVSSS	SPOP	0.9927	More...
P34910	Protein EVI2B	DEG_SPOP_SBC_1	329:333	AVSSS	SPOP	0.9223	More...
Q5U5X8	Protein FAM222A	DEG_SPOP_SBC_1	109:113	AVSSS	SPOP	0.9845	More...
Q68D20	Protein PMS2CL	DEG_SPOP_SBC_1	88:92	AVSSS	SPOP	0.7454	More...
P43359	Putative melanoma-associated antigen 5P	DEG_SPOP_SBC_1	38:42	AVSSS	SPOP	0.8963	More...
Q9NSC2	Sal-like protein 1	DEG_SPOP_SBC_1	369:373	AVSSS	SPOP	0.7672	More...
Q9H2S1	Small conductance calcium-activated potassium channel protein 2	DEG_SPOP_SBC_1	58:62	AVSSS	SPOP	0.5155	More...

Showing 1 to 25 of 35 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: AVSSS

Degron related mutations and impact score

Drug responses associated with MAGEA4 mutations

All proteins holding degron of AVSSS