DegronMD

Uniprot ID: Q685J3

Source protein: Mucin-17

Source gene: MUC17

Class: DEG_SPOP_SBC_1

Location: 1844:1848

E3 ligase: SPOP

DEGRON score: 0.8391

ASA_SCORE: 83.7

COIL: 0.9292

CONS_SCORE: 0.5236

DSS_SCORE: 0.5753

HELIX: 0.0106

FCONS_SCORE: 1

RIG_SCORE: 0.6335

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1849A	TCGA-24-2035	OV	TCGA	AVSSS	DEG_SPOP_SBC_1	0.3056
p.P1849A	DO29598	OV	ICGC	AVSSS	DEG_SPOP_SBC_1	0.3056
p.V1839L	TCGA-52-7811	LUSC	TCGA	AVSSS	DEG_SPOP_SBC_1	0.1944
p.V1839L	DO26569	LUSC	ICGC	AVSSS	DEG_SPOP_SBC_1	0.1944
p.P1849S	TCGA-BS-A0TJ	UCEC	TCGA	AVSSS	DEG_SPOP_SBC_1	0.3056
p.P1849S	DO42953	UCEC	ICGC	AVSSS	DEG_SPOP_SBC_1	0.3056
p.S1837N	TCGA-D3-A2JK	SKCM	TCGA	AVSSS	DEG_SPOP_SBC_1	0.1389
p.S1837N	DO37619	SKCM	ICGC	AVSSS	DEG_SPOP_SBC_1	0.1389
p.S1847L	TCGA-EE-A2GI	SKCM	TCGA	AVSSS	DEG_SPOP_SBC_1	0.7667
p.S1847L	TCGA-GN-A8LN	SKCM	TCGA	AVSSS	DEG_SPOP_SBC_1	0.7667
p.S1847L	DO37410	SKCM	ICGC	AVSSS	DEG_SPOP_SBC_1	0.7667
p.S1847L	DO51262	SKCM	ICGC	AVSSS	DEG_SPOP_SBC_1	0.7667
p.V1839G	DO222388	BTCA	ICGC	AVSSS	DEG_SPOP_SBC_1	0.1944
p.A1858P	DO224685	COCA	ICGC	AVSSS	DEG_SPOP_SBC_1	0.0556
p.A1858P	DO224731	COCA	ICGC	AVSSS	DEG_SPOP_SBC_1	0.0556
p.A1858P	DO229016	COCA	ICGC	AVSSS	DEG_SPOP_SBC_1	0.0556
p.I1857M	DO224731	COCA	ICGC	AVSSS	DEG_SPOP_SBC_1	0.0833
p.I1857M	DO222560	COCA	ICGC	AVSSS	DEG_SPOP_SBC_1	0.0833
p.I1857M	DO229016	COCA	ICGC	AVSSS	DEG_SPOP_SBC_1	0.0833
p.A1852T	DO224754	COCA	ICGC	AVSSS	DEG_SPOP_SBC_1	0.2222
p.A1852T	DO229016	COCA	ICGC	AVSSS	DEG_SPOP_SBC_1	0.2222
p.A1852T	DO218898	SKCA	ICGC	AVSSS	DEG_SPOP_SBC_1	0.2222
p.E1853D	DO229016	COCA	ICGC	AVSSS	DEG_SPOP_SBC_1	0.1944
p.E1853D	DO46877	RECA	ICGC	AVSSS	DEG_SPOP_SBC_1	0.1944
p.T1855S	DO229016	COCA	ICGC	AVSSS	DEG_SPOP_SBC_1	0.1389
p.T1855S	RERF-LC-Sq1	lung	COSMIC	AVSSS	DEG_SPOP_SBC_1	0.1389
p.T1855S	ECC10	stomach	COSMIC	AVSSS	DEG_SPOP_SBC_1	0.1389
p.T1855S	8505C	thyroid	COSMIC	AVSSS	DEG_SPOP_SBC_1	0.1389
p.T1855S	PL-21	haematopoietic_and_lymphoid_tissue	COSMIC	AVSSS	DEG_SPOP_SBC_1	0.1389
p.T1855S	KMRC-1	kidney	COSMIC	AVSSS	DEG_SPOP_SBC_1	0.1389
p.T1855S	BFTC-909	kidney	COSMIC	AVSSS	DEG_SPOP_SBC_1	0.1389
p.T1855S	MKN28	stomach	COSMIC	AVSSS	DEG_SPOP_SBC_1	0.1389
p.T1855S	LK-2	lung	COSMIC	AVSSS	DEG_SPOP_SBC_1	0.1389
p.T1855S	KMS-12-BM	haematopoietic_and_lymphoid_tissue	COSMIC	AVSSS	DEG_SPOP_SBC_1	0.1389
p.T1855S	SNU-61	large_intestine	COSMIC	AVSSS	DEG_SPOP_SBC_1	0.1389
p.T1855S	TE-12	oesophagus	COSMIC	AVSSS	DEG_SPOP_SBC_1	0.1389
p.T1855S	SBC-1	lung	COSMIC	AVSSS	DEG_SPOP_SBC_1	0.1389
p.T1855S	NY	bone	COSMIC	AVSSS	DEG_SPOP_SBC_1	0.1389
p.T1855S	RH-18	soft_tissue	COSMIC	AVSSS	DEG_SPOP_SBC_1	0.1389
p.T1855S	P12-ICHIKAWA	haematopoietic_and_lymphoid_tissue	COSMIC	AVSSS	DEG_SPOP_SBC_1	0.1389
p.T1855S	KP-4	pancreas	COSMIC	AVSSS	DEG_SPOP_SBC_1	0.1389
p.T1855S	RCC-ER	kidney	COSMIC	AVSSS	DEG_SPOP_SBC_1	0.1389
p.T1855S	JHH-6	liver	COSMIC	AVSSS	DEG_SPOP_SBC_1	0.1389
p.T1855S	TMK-1	stomach	COSMIC	AVSSS	DEG_SPOP_SBC_1	0.1389
p.T1855S	NCI-SNU-16	stomach	COSMIC	AVSSS	DEG_SPOP_SBC_1	0.1389
p.T1855S	KYSE-140	oesophagus	COSMIC	AVSSS	DEG_SPOP_SBC_1	0.1389
p.T1855S	MOLM-16	haematopoietic_and_lymphoid_tissue	COSMIC	AVSSS	DEG_SPOP_SBC_1	0.1389
p.T1855S	KY821	haematopoietic_and_lymphoid_tissue	COSMIC	AVSSS	DEG_SPOP_SBC_1	0.1389
p.T1855S	HGC-27	stomach	COSMIC	AVSSS	DEG_SPOP_SBC_1	0.1389
p.T1855S	AM-38	central_nervous_system	COSMIC	AVSSS	DEG_SPOP_SBC_1	0.1389
p.T1855S	YH-13	central_nervous_system	COSMIC	AVSSS	DEG_SPOP_SBC_1	0.1389
p.T1855S	IM-95	stomach	COSMIC	AVSSS	DEG_SPOP_SBC_1	0.1389
p.T1855S	SNU-423	liver	COSMIC	AVSSS	DEG_SPOP_SBC_1	0.1389
p.T1855S	CML-T1	haematopoietic_and_lymphoid_tissue	COSMIC	AVSSS	DEG_SPOP_SBC_1	0.1389
p.T1855S	HCC1419	breast	COSMIC	AVSSS	DEG_SPOP_SBC_1	0.1389
p.T1855S	SNU-283	large_intestine	COSMIC	AVSSS	DEG_SPOP_SBC_1	0.1389
p.T1855S	SNU-C5	large_intestine	COSMIC	AVSSS	DEG_SPOP_SBC_1	0.1389
p.T1855S	KINGS-1	central_nervous_system	COSMIC	AVSSS	DEG_SPOP_SBC_1	0.1389
p.A1844E	DO229016	COCA	ICGC	AVSSS	DEG_SPOP_SBC_1	0.7701
p.S1846T	DO229016	COCA	ICGC	AVSSS	DEG_SPOP_SBC_1	0.6005
p.P1851T	DO229016	COCA	ICGC	AVSSS	DEG_SPOP_SBC_1	0.25
p.P1851T	DO45151	LIRI	ICGC	AVSSS	DEG_SPOP_SBC_1	0.25
p.V1845G	DO229016	COCA	ICGC	AVSSS	DEG_SPOP_SBC_1	0.6421
p.P1849L	DO229016	COCA	ICGC	AVSSS	DEG_SPOP_SBC_1	0.3056
p.T1855I	SIDM00253	Neuroblastoma	GDSC	AVSSS	DEG_SPOP_SBC_1	0.1389
p.T1855I	SIDM01179	Other Sarcomas	GDSC	AVSSS	DEG_SPOP_SBC_1	0.1389
p.T1855I	SIDM00756	Non-Small Cell Lung Carcinoma	GDSC	AVSSS	DEG_SPOP_SBC_1	0.1389
p.T1855I	SIDM00736	Non-Cancerous	GDSC	AVSSS	DEG_SPOP_SBC_1	0.1389
p.S1846I	SIDM01099	Neuroblastoma	GDSC	AVSSS	DEG_SPOP_SBC_1	0.7341
p.S1846I	ACH-000341	Neuroblastoma	CCLE	AVSSS	DEG_SPOP_SBC_1	0.7341

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P17483	Homeobox protein Hox-B4	DEG_SPOP_SBC_1	112:116	AVSSS	SPOP	0.9569	More...
P32242	Homeobox protein OTX1	DEG_SPOP_SBC_1	131:135	AVSSS	SPOP	0.9911	More...
P34910	Protein EVI2B	DEG_SPOP_SBC_1	329:333	AVSSS	SPOP	0.9223	More...
P43358	Melanoma-associated antigen 4	DEG_SPOP_SBC_1	39:43	AVSSS	SPOP	0.8472	More...
P54278	Mismatch repair endonuclease PMS2	DEG_SPOP_SBC_1	474:478	AVSSS	SPOP	0.999	More...
P84996	Protein ALEX	DEG_SPOP_SBC_1	603:607	AVSSS	SPOP	0.9965	More...
Q06455	Protein CBFA2T1	DEG_SPOP_SBC_1	565:569	AVSSS	SPOP	0.9927	More...
Q0VDD7	Break repair meiotic recombinase recruitment factor 1	DEG_SPOP_SBC_1	66:70	AVSSS	SPOP	0.9837	More...
Q13613	Myotubularin-related protein 1	DEG_SPOP_SBC_1	643:647	AVSSS	SPOP	0.8381	More...
Q15326	Zinc finger MYND domain-containing protein 11	DEG_SPOP_SBC_1	417:421	AVSSS	SPOP	0.6553	More...
Q15714	TSC22 domain family protein 1	DEG_SPOP_SBC_1	279:283	AVSSS	SPOP	0.9984	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1491:1495	AVSSS	SPOP	0.9129	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1844:1848	AVSSS	SPOP	0.8391	More...
Q8IZA0	Dyslexia-associated protein KIAA0319-like protein	DEG_SPOP_SBC_1	173:177	AVSSS	SPOP	0.8972	More...
Q8NEY8	Periphilin-1	DEG_SPOP_SBC_1	211:215	AVSSS	SPOP	0.9988	More...
Q92562	Polyphosphoinositide phosphatase	DEG_SPOP_SBC_1	753:757	AVSSS	SPOP	0.9974	More...
Q96JE9	Microtubule-associated protein 6	DEG_SPOP_SBC_1	296:300	AVSSS	SPOP	0.8997	More...
Q99973	Telomerase protein component 1	DEG_SPOP_SBC_1	1674:1678	AVSSS	SPOP	0.8128	More...
Q9H2S1	Small conductance calcium-activated potassium channel protein 2	DEG_SPOP_SBC_1	58:62	AVSSS	SPOP	0.5155	More...
Q9HCK8	Chromodomain-helicase-DNA-binding protein 8	DEG_SPOP_SBC_1	142:146	AVSSS	SPOP	0.9881	More...
Q9NSC2	Sal-like protein 1	DEG_SPOP_SBC_1	369:373	AVSSS	SPOP	0.7672	More...
Q9ULH7	Myocardin-related transcription factor B	DEG_SPOP_SBC_1	437:441	AVSSS	SPOP	0.6865	More...
Q9UPA5	Protein bassoon	DEG_SPOP_SBC_1	3392:3396	AVSSS	SPOP	0.8731	More...
Q9Y4F4	TOG array regulator of axonemal microtubules protein 1	DEG_SPOP_SBC_1	77:81	AVSSS	SPOP	0.8214	More...
Q9Y4X4	Krueppel-like factor 12	DEG_SPOP_SBC_1	95:99	AVSSS	SPOP	0.9994	More...
Q53QW1	Testis-expressed protein 44	DEG_SPOP_SBC_1	36:40	AVSSS	SPOP	0.9324	More...
Q96PX9	Pleckstrin homology domain-containing family G member 4B	DEG_SPOP_SBC_1	1174:1178	AVSSS	SPOP	0.7969	More...
P43359	Putative melanoma-associated antigen 5P	DEG_SPOP_SBC_1	38:42	AVSSS	SPOP	0.8963	More...
Q6ZRI6	Uncharacterized protein C15orf39	DEG_SPOP_SBC_1	934:938	AVSSS	SPOP	0.9935	More...
Q8IW70	Transmembrane protein 151B	DEG_SPOP_SBC_1	439:443	AVSSS	SPOP	0.8829	More...
Q8TCN5	Zinc finger protein 507	DEG_SPOP_SBC_1	860:864	AVSSS	SPOP	0.8942	More...
Q9P2C4	Transmembrane protein 181	DEG_SPOP_SBC_1	25:29	AVSSS	SPOP	0.8665	More...
Q5U5X8	Protein FAM222A	DEG_SPOP_SBC_1	109:113	AVSSS	SPOP	0.9845	More...
Q68D20	Protein PMS2CL	DEG_SPOP_SBC_1	88:92	AVSSS	SPOP	0.7454	More...
Q9NQ32	Uncharacterized protein C11orf16	DEG_SPOP_SBC_1	333:337	AVSSS	SPOP	0.8372	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: AVSSS

Degron related mutations and impact score

Drug responses associated with MUC17 mutations

All proteins holding degron of AVSSS