DegronMD - Q5U5X8(FAM222A)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.N80H	TCGA-14-0866	GBM	TCGA	DTSGQRYSPYP	CBL_PTK	83:93	Mutation rewiring degron network	0.25
p.N80H	DO11878	GBM	ICGC	DTSGQRYSPYP	CBL_PTK	83:93	Mutation rewiring degron network	0.25
p.A108T	TCGA-2W-A8YY	CESC	TCGA	AVSSS	DEG_SPOP_SBC_1	109:113	Mutation rewiring degron network	0.3056
p.A108T	DO223732	CESC	ICGC	AVSSS	DEG_SPOP_SBC_1	109:113	Mutation rewiring degron network	0.3056
p.Q87K	TCGA-BC-A8YO	LIHC	TCGA	DTSGQRYSPYP	CBL_PTK	83:93	Mutation altering degron motif	0.5833
p.Q87K	DO49658	LIHC	ICGC	DTSGQRYSPYP	CBL_PTK	83:93	Mutation altering degron motif	0.5833
p.T115K	TCGA-CC-5258	LIHC	TCGA	AVSSS	DEG_SPOP_SBC_1	109:113	Mutation blocking phosphorylation signal	0.7222
p.T115K	DO22881	LIHC	ICGC	AVSSS	DEG_SPOP_SBC_1	109:113	Mutation blocking phosphorylation signal	0.7222
p.R88C	TCGA-DI-A1BU	UCEC	TCGA	DTSGQRYSPYP	CBL_PTK	83:93	Mutation altering degron motif	0.719
p.R88C	DO42023	UCEC	ICGC	DTSGQRYSPYP	CBL_PTK	83:93	Mutation altering degron motif	0.719
p.A122T	DO230312	COCA	ICGC	AVSSS	DEG_SPOP_SBC_1	109:113	Mutation rewiring degron network	0.0833
p.A122T	DO41199	UCEC	ICGC	AVSSS	DEG_SPOP_SBC_1	109:113	Mutation rewiring degron network	0.0833
p.A122T	SIDM00122	Breast Carcinoma	GDSC	AVSSS	DEG_SPOP_SBC_1	109:113	Mutation rewiring degron network	0.0833
p.A122T	SIDM00217	Colorectal Carcinoma	GDSC	AVSSS	DEG_SPOP_SBC_1	109:113	Mutation rewiring degron network	0.0833
p.A119V	DO52453	COCA	ICGC	AVSSS	DEG_SPOP_SBC_1	109:113	Mutation rewiring degron network	0.1667
p.A119V	DO52438	COCA	ICGC	AVSSS	DEG_SPOP_SBC_1	109:113	Mutation rewiring degron network	0.1667
p.A119V	DO229003	COCA	ICGC	AVSSS	DEG_SPOP_SBC_1	109:113	Mutation rewiring degron network	0.1667
p.A119V	SIDM01034	B-Lymphoblastic Leukemia	GDSC	AVSSS	DEG_SPOP_SBC_1	109:113	Mutation rewiring degron network	0.1667
p.A119V	SIDM01219	Non-Small Cell Lung Carcinoma	GDSC	AVSSS	DEG_SPOP_SBC_1	109:113	Mutation rewiring degron network	0.1667
p.A119V	SIDM01028	Esophageal Squamous Cell Carcinoma	GDSC	AVSSS	DEG_SPOP_SBC_1	109:113	Mutation rewiring degron network	0.1667
p.A119V	SIDM00592	Oral Cavity Carcinoma	GDSC	AVSSS	DEG_SPOP_SBC_1	109:113	Mutation rewiring degron network	0.1667
p.A119V	SIDM00282	Colorectal Carcinoma	GDSC	AVSSS	DEG_SPOP_SBC_1	109:113	Mutation rewiring degron network	0.1667
p.A119V	SIDM00996	Thyroid Gland Carcinoma	GDSC	AVSSS	DEG_SPOP_SBC_1	109:113	Mutation rewiring degron network	0.1667
p.A119V	SIDM01689	B-Lymphoblastic Leukemia	GDSC	AVSSS	DEG_SPOP_SBC_1	109:113	Mutation rewiring degron network	0.1667
p.A119V	SIDM01782	Oral Cavity Carcinoma	GDSC	AVSSS	DEG_SPOP_SBC_1	109:113	Mutation rewiring degron network	0.1667
p.S111F	SIDM01000	Melanoma	GDSC	AVSSS	DEG_SPOP_SBC_1	109:113	Mutation altering degron motif	0.7982
p.S111F	ACH-000304	Skin Cancer	CCLE	AVSSS	DEG_SPOP_SBC_1	109:113	Mutation altering degron motif	0.7982
p.S111F	WM-115	skin	COSMIC	AVSSS	DEG_SPOP_SBC_1	109:113	Mutation altering degron motif	0.7982
p.G120R	ACH-001401	Adrenal Cancer	CCLE	AVSSS	DEG_SPOP_SBC_1	109:113	Mutation rewiring degron network	0.1389
p.Q100R	ACH-002179	Breast Cancer	CCLE	AVSSS	DEG_SPOP_SBC_1	109:113	Mutation rewiring degron network	0.0833
p.Q100R	ACH-002179	Breast Cancer	CCLE	DTSGQRYSPYP	CBL_PTK	83:93	Mutation rewiring degron network	0.1389
p.Q100R	OCUB-M	breast	COSMIC	AVSSS	DEG_SPOP_SBC_1	109:113	Mutation rewiring degron network	0.0833
p.Q100R	OCUB-M	breast	COSMIC	DTSGQRYSPYP	CBL_PTK	83:93	Mutation rewiring degron network	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FAM222A

UniProt ID: Q5U5X8

Entrez ID: 84915

Protein name: Protein FAM222A

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FAM222A in