DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
DTSGQRYSPYP
Uniprot ID:
Q5U5X8
Source protein:
Protein FAM222A
Source gene:
FAM222A
Class:
CBL_PTK
Location:
83:93
E3 ligase:
CBL
DEGRON score:
0.9973
ASA_SCORE:
66.4
COIL:
0.8419
CONS_SCORE:
0.9134
DSS_SCORE:
0.4993
HELIX:
0.0384
FCONS_SCORE:
1.0457
RIG_SCORE:
0.7021
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.N80H
TCGA-14-0866
GBM
TCGA
DTSGQRYSPYP
CBL_PTK
0.25
p.N80H
DO11878
GBM
ICGC
DTSGQRYSPYP
CBL_PTK
0.25
p.Q87K
TCGA-BC-A8YO
LIHC
TCGA
DTSGQRYSPYP
CBL_PTK
0.5833
p.Q87K
DO49658
LIHC
ICGC
DTSGQRYSPYP
CBL_PTK
0.5833
p.R88C
TCGA-DI-A1BU
UCEC
TCGA
DTSGQRYSPYP
CBL_PTK
0.719
p.R88C
DO42023
UCEC
ICGC
DTSGQRYSPYP
CBL_PTK
0.719
p.Q100R
ACH-002179
Breast Cancer
CCLE
DTSGQRYSPYP
CBL_PTK
0.1389
p.Q100R
OCUB-M
breast
COSMIC
DTSGQRYSPYP
CBL_PTK
0.1389
Drug responses associated with FAM222A mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DTSGQRYSPYP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q5U5X8
Protein FAM222A
CBL_PTK
83:93
DTSGQRYSPYP
CBL
0.9973
More...
